Table of Content

22 October 2024, Volume 54 Issue 10 Previous Issue    Next Issue

Basic research

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Corrosion-inhibiting effects of triazinyl Gemini surfactants on carbon steel in aqueous solution containing 0.5 mol/L H2SO4 Mengying Yuan, Dehua Wang, Huikai Nan, Tao Geng, Hongyi Liu, Hailin Zhu 2024, 54 (10):  1145-1154.  doi: 10.3969/j.issn.2097-2806.2024.10.001 Abstract ( 2802 )   HTML ( 18 )   PDF (7806KB) ( 56 )   The triazinyl Gemini surfactants with different hydrophobic chain lengths （Cm-2-Cm, m=6, 8, 12） were synthesized by using cyanuric chloride, hexylamine/octylamine/dodecylamine, ethylenediamine,N, N-dimethyl-1, 3-propanediamine and bromoethane as raw materials. The molecular structure was characterized by FT-IR, 1H NMR and ESI-MS. The surface activities of the three triazinyl Gemini surfactants （C6-2-C6, C8-2-C8 and C12-2-C12） were investigated by surface tension method. Their corrosion-inhibition properties on 45# carbon steel in 0.5 mol/L H2SO4 were studied by static weight loss method, electrochemical impedance spectroscopy, potentiodynamic polarization and quantum chemistry. The results showed that, when the carbon number of hydrophobic chain was increased from 6 to 12, the critical micelle concentration （cmc） of the triazinyl Gemini surfactant was decreased from 0.059 mmol/L to 0.013 mmol/L, and meanwhile the pc20 value was increased from 1.23 to 1.89. The results of electrochemical impedance showed that, the corrosion inhibition efficiency increased with the increase of carbon number of hydrophobic chain for the surfactants at the same concentration. The inhibition efficiency could reach 95.03% for 45# carbon steel in 0.5 mol/L H2SO4 when adding 0.2 mmol/L C12-2-C12. The results of potentiodynamic polarization showed that the three surfactants were mixed corrosion inhibitors which mainly inhibited the cathode. These three triazinyl Gemini surfactants could effectively adsorb on the carbon steel surface, as shown by the results of quantum chemical calculation. Figures and Tables | References | Related Articles | Metrics

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Study on the mixed systems of polyether organosilicon surfactant and classic anionic surfactants Xinzhi Liang, Ting Sun, Xinyao Ye, Yukai Wang, Liang Bai, Hongguang Li 2024, 54 (10):  1155-1165.  doi: 10.3969/j.issn.2097-2806.2024.10.002 Abstract ( 2083 )   HTML ( 10 )   PDF (9356KB) ( 62 )   Polyether organosilicon surfactants have received widespread attention in recent years due to their excellent surface activities. To further expand the downstream application and develop a surfactant formula, in this work, a polyether modified trisiloxane surfactant was mixed with a classical anionic surfactant （alkyl glycoside sulfonate or fatty-alcohol polyethoxylate phosphate）, and the mixed adsorption parameters and mixed micellization parameters of the binary surfactant mixtures were investigated in detail. For the selected mixing ratio, the dispersing performance of binary surfactant mixtures was evaluated in common model systems （foam, emulsion, suspension）, which could provide an important reference for the application and development of systems of polyether modified silicone surfactants. Figures and Tables | References | Related Articles | Metrics

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Molecular simulation study on the behavior of long-alkyl-chain betaine surfactants at the interface between water and the oil Fei Yi, Fantao Meng, Bin Chen, Hao Xu, Xiaoyan Wu, Xiaoliang Li 2024, 54 (10):  1166-1171.  doi: 10.3969/j.issn.2097-2806.2024.10.003 Abstract ( 1778 )   HTML ( 6 )   PDF (5799KB) ( 42 )   With the large-scale implementation of chemical flooding, the demand for surfactants has increased sharply. Betaine surfactants are a type of efficient displacement agent suitable for multi-scenario exploitation in oilfields due to their excellent interfacial activity, salt resistance, and environmental friendliness. Molecular dynamics simulations were used to study the oil-water interface behavior and microscopic molecular configuration of betaine surfactants with different hydrophobic chain lengths and hydrophilic groups, so as to explore the interfacial activity of long-alkyl-chain betaine surfactants at the molecular level, and explain the recovery-enhancing mechanism. Through mutual verification between the simulation results and experimental data, microscopic explanations for macroscopic experimental phenomena were provided. Furthermore, the interfacial action mechanism of long-alkyl-chain betaine surfactants was summarized, providing guidance for the design of displacement agents based on the interface migration and distribution by molecular simulation. Figures and Tables | References | Related Articles | Metrics

Lecture of science and technology

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Preparation, properties and applications of natural biomass materials （Ⅹ） The stable, highly viscous, water-soluble microbial polysaccharides: xanthan gum Niya Lv, Yanshuang Zhang, Guimei Han, Jinshi Fan 2024, 54 (10):  1172-1180.  doi: 10.3969/j.issn.2097-2806.2024.10.004 Abstract ( 1617 )   HTML ( 8 )   PDF (6644KB) ( 38 )   Xanthan gum is a kind of extracellular polysaccharides produced by xanthomonas. It is a heteropolysaccharide polymer with high molecular weight formed by a series of five-sugar residues repeating units. Xanthan gum and its derivatives are widely used in various industries such as daily-use chemical industry, food processing industry, pharmaceutical industry, water treatment, and oil exploitation, due to their excellent stability, thickening ability, emulsifying ability, suspensibility, rheological property, acid resistance, base resistance, heat resistance, salt resistance, and other fit properties. In this paper, the chemical structure, the main physicochemical properties, the production methods, and the modification technologies of xanthan gum, as well as the properties, the preparation, separation and purification methods of xanthan gum oligosaccharides are briefly presented. Furthermore, the application status of xanthan gum and its modified products, the current problems in xanthan gum production, and the future prospects for the development of xanthan gum are also mentioned in this paper. Figures and Tables | References | Related Articles | Metrics

Development and application

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Experimental study of non-aqueous foams stabilized with different surfactant aggregates Ziwei Zhang, Yongli Yan, Bingcheng He, Longlong Dou, Song Shi 2024, 54 (10):  1181-1190.  doi: 10.3969/j.issn.2097-2806.2024.10.005 Abstract ( 1543 )   HTML ( 7 )   PDF (6946KB) ( 43 )   Non-aqueous foams have wide applications in cosmetics, porous materials, biomedicine, oil and gas development, etc. However, due to the low surface tension of non-aqueous solvents, they have difficulty in foaming and their foams usually have poor stability. Therefore, relevant field has been a difficult problem to overcome. Surfactant aggregates are widely used in related field due to their high density and ordered structure. In this work, different surfactant aggregates were prepared and characterized, in which sodium dodecyl sulfonate and sodium dodecylbenzene sulfonate were used as the main agents, and formamide and decanol were used as the non-aqueous phase. Then their foaming ability and foam stability for non-aqueous solvents were observed. The results showed that all these surfactant aggregates were of layered liquid crystal structure, belonging to non-Newtonian fluids, which had shear-thinning rheological phenomenon. The higher the content of surfactant, the more stable the layered liquid crystal structure of the surfactant aggregates. The foam volume was first increased and then decreased with the increase of layered liquid crystal content. The foam-stabilizing ability of SDBS/decanol/formamide system was better than that of SDS/decanol/formamide system. When formamide was used as the non-aqueous phase and the layered liquid crystal content in the SDBS/decanol/formamide system was 60% （w/%）, the foam life was more than 55 h. When the non-aqueous phase was decanol and the layered liquid crystal content in the SDBS/decanol/formamide system was 60% （w/%）, the foam life lasted for more than 6 h. Figures and Tables | References | Related Articles | Metrics

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Preparation of phospholipid-based microemulsion and properties of loaded resveratrol Baotong Jia, Kuan Chang 2024, 54 (10):  1191-1200.  doi: 10.3969/j.issn.2097-2806.2024.10.006 Abstract ( 68 )   HTML ( 8 )   PDF (7275KB) ( 35 )   An O/W microemulsion （ME） was prepared by compounding soybean phospholipids and alkylglycoside sodium hydroxypropyl sulfonate （APGSHS） as the emulsifiers in a 2∶1 ratio. The optimal formulation was determined by the ternary phase diagram method: 1, 2-hexanediol as the co-surfactant, dibutyl adipate as the oil phase, the mass ratio of the complex surfactant to the co-surfactant （Km） of 1∶2, the mass fraction of dibutyl adipate in the system of 8.00%, and the amount of water added of 60.00%, and the concentration of inorganic salts in the water of 0.1 mol/L.Transmission electron microscopy show that the microemulsion is spherical, with oil droplets uniformly distributed, and the particle size is 15-25 nm. The maximum loading of the system for resveratrol is （11.55±0.14） mg/mL, which shows a good solubilization effect. At 1.00% resveratrol loading, the microemulsion shows good stabilization effect, with a retention rate of 77.13%±0.51% after 28 days of storage at 50 ℃, which is 19.21% higher than that of the unwrapped one, and a retention rate of 57.21%±0.32% after 32 h of storage at 365 nm UV illumination, which is 20.72% higher than that of the unwrapped one. The transdermal permeation amount of resveratrol in this system is up to （461.12±35.01）μg/cm2 for 24 h, which has a good osmotic effect on insoluble polyphenolic compounds. Figures and Tables | References | Related Articles | Metrics

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Preparation and properties of O/W microemulsion of Alpinia oxyphylla Miq. essential oil Xiaoli Xie, Xuan Hu, Ying Huang, Kai Wang, Dan Wang, Fulai Yu 2024, 54 (10):  1201-1210.  doi: 10.3969/j.issn.2097-2806.2024.10.007 Abstract ( 60 )   HTML ( 6 )   PDF (7612KB) ( 40 )   Alpinia oxyphylla Miq. extract is a kind of natural cosmetic raw material, which can be used as plant functional oil. In order to obtain a stable O/W microemulsion of Alpinia oxyphylla Miq. essential oil（AOEO）, the O/W microemulsion containing AOEO was constructed by pseudo ternary phase diagram method. The effects of surfactants, cosurfactants, Km （mass ratio of surfactant to cosurfactant）, and their different components and ratios on the area of the microemulsion were investigated. The particle size, morphology, conductivity, water solubility and stability of the microemulsion were measured, and its characterization and physicochemical properties were discussed. The results show that the optimal formula of O/W microemulsion of AOEO is obtained as follows: m（castor oil polyoxyethylene ether 40 （EL-40）） ∶m（1,2-propylene glycol） ∶m（AOEO）=10.5∶3.5∶6, the transition point of O/W microemulsion is 60% （mass fraction）. The average particle size of the O/W microemulsion is （26.580±0.133） nm, the polydispersion index （PDI） is 0.226±0.010, and the microemulsion is slightly spherical or quasi-spherical, regular, and without adhering edges under transmission electron microscopy （TEM） and digital biological microscopy （DBM）. The microemulsion has good water solubility, centrifugal stability, thermal stability and low temperature storage stability. The results show that the nano-coating of AOEO can be realized by using microemulsion as carrier, which provides reference for the development and application of AOEO in daily chemical field. Figures and Tables | References | Related Articles | Metrics

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Study on the influences of surfactants on the antibacterial effect of PCMX Qinggang Liu 2024, 54 (10):  1211-1217.  doi: 10.3969/j.issn.2097-2806.2024.10.008 Abstract ( 58 )   HTML ( 4 )   PDF (5275KB) ( 36 )   The solubilization effects of three surfactants, i.e., SDS, AES and AEO9, on PCMX （parachlorometaxylenol） were studied, as well as their combined impact on the antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The results indicated that, the binding coefficient of surfactant with PCMX was influenced by the concentration of surfactant in the following order: AEO9>AES>SDS. The influences of surfactants on the antibacterial effect of PCMX were examined through minimum inhibitory concentration （MIC） testing. For the SDS concentrations below its critical micelle concentration （cmc）, the MIC of the PCMX complex remained unchanged. However, a further increase in SDS concentration beyond the cmc would lead to a linear increase in MIC. In the case of AES below cmc, the MIC of the PCMX complex was slightly decreased with the concentration of AES, while the AES in the concentration range above cmc would cause a linear increase of MIC. When the concentration of AEO9 was≤1.61 mmol/L, the increase of AEO9 concentration would lead to a decrease in MIC against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Above the cmc of AEO9, there was a concentration range in which the increase of AEO9 concentration could enhance the antibacterial efficacy of the system. This study might provide valuable insights into the synergism between surfactants and PCMX in antibacterial effectiveness. Figures and Tables | References | Related Articles | Metrics

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Study on the effect of four kinds of raw materials in hypertonic dehydration cell model Yuanyuan Gao, Qidan Tan, Chencan Cao, Haifeng Chen, Yuying Jia, Lei Liu 2024, 54 (10):  1218-1226.  doi: 10.3969/j.issn.2097-2806.2024.10.009 Abstract ( 68 )   HTML ( 8 )   PDF (6336KB) ( 40 )   It aims to investigate the protective effects of sodium hyaluronate, panthenol, Portulaca oleracea L. and Calendula officinalis L. on hyperosmotic dehydration-induced injury of human immortalized keratinocytes （HaCaT）. The safety mass concentrations of four raw materials were screened by detecting cell viability, and the secretion of hyaluronic acid （HA） was determined using the ELISA method. The expression of HaCaT barrier function related genes （OVOL1, EREG, TGM1, TGM2, IVL, IRF6, THBS1, CASP14） was detected at the mRNA level to explore the regulatory effect of four raw materials on these genes. The results demonstrate that pretreatment with the four kinds of raw materials could increase the cell viability after hyperosmotic dehydration, promote the secretion of HA, and improve the expression of barrier function related genes after hyperosmotic dehydration, among which panthenol and Calendula officinalis L. are better. The results show that the four raw materials have a certain protective effect on the hyperosmotic dehydration cell model, which provides data support for its application in cosmetics. Figures and Tables | References | Related Articles | Metrics

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Preparation of PMTMS/TiO2 composite material and its performance characterization Wanping Zhang, Xin Guan, Shilian Zheng, Dongmei Zhang, Zijia Zhang, Qianjie Zhang 2024, 54 (10):  1227-1234.  doi: 10.3969/j.issn.2097-2806.2024.10.010 Abstract ( 51 )   HTML ( 4 )   PDF (5899KB) ( 27 )   To mitigate the aggregation behavior of TiO2 in organic system and also to enhance the synthesis efficiency of the composite carrier, methyltrimethoxysilane （MTMS） was used to coat TiO2. The surface morphology and properties of the coated PMTMS/TiO2 composites were characterized by the methods of FTIR, TGA, SEM, EDS, DLS, contact angle test, and lipophilicity test. The coating mechanism for PMTMS/TiO2 composites was summarized and elaborated. The results showed that the aggregation of PMTMS/TiO2 composites was greatly reduced when the synthesis condition was as follows: The mass ratio of MTMS to TiO2 was 3∶1, the mass fraction of catalyst was 1.9% and the reaction time was 5 h. The PMTMS/TiO2 composites thus prepared had good hydrophobicity. Therefore, by this way, the dispersion and compatibility of TiO2 particles in organic solvents were significantly improved. Figures and Tables | References | Related Articles | Metrics

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Analysis of the effectiveness of Lotus leaf extract in inhibiting oral bacteria and improving gingival inflammation Juanli Liu, Huiping Xu, Yanfang Liu, Zhenhua Dong, Meiyan Wang 2024, 54 (10):  1235-1242.  doi: 10.3969/j.issn.2097-2806.2024.10.011 Abstract ( 69 )   HTML ( 6 )   PDF (5760KB) ( 37 )   This study aimed to analyze the effectiveness of Lotus leaf extract （LLE） in inhibiting oral bacteria and improving gingival inflammation. LLE of different mass concentrations was used to treat 10 common oral bacteria for 24 hours, and the minimum inhibitory concentration （MIC） and inhibition zone diameter were measured respectively. The CCK-8 method was used to detect the effect of LLE on the viability of human gingival epithelial cells. Human gingival epithelial cells were divided into control group （Control）, lipopolysaccharides （LPS） group and LPS+1-500 μg/mL LLE group. Human gingival epithelial cells were treated with 1 μg/mL LPS and different mass concentrations of LLE respectively for 24 h. RT-qPCR were used to detect the mRNA levels of interleukin （IL）-1β, IL-6, IL-8, tumor necrosis factor-α （TNF-α）, and intercellular adhesion molecule-1 （ICAM-1）. Western blotting were used to detect the phosphorylation levels of nuclear factor-κB （NF-κB） p65 and p38 mitogen-activated protein kinase （MAPK）. The results show that the MICs of LLE against 10 common oral bacteria are 300-500 μg/mL, respectively. Compared with the Control group, the relative mRNA levels of IL-1β, IL-6, IL-8, TNF-α and ICAM-1 in human gingival epithelial cells in the LPS group are all increased, and the phosphorylation levels of NF-κB p65 and p38 MAPK are all increased （P<0.05）. Compared with the LPS group, the relative mRNA levels of IL-1β, IL-6, IL-8, TNF-α and ICAM-1 in human gingival epithelial cells in the LPS+50-500 μg/mL LLE group are all decreased in a dose-dependent manner, and the phosphorylation levels of NF-κB p65 and p38 MAPK are decreased in a dose-dependent manner （P<0.05）. This study shows that LLE has inhibitory activity against 10 common oral bacteria and LPS-induced excessive inflammation of human gingival epithelial cells, and it may be an effective ingredient in oral care products. Figures and Tables | References | Related Articles | Metrics

Reviews

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Application of multiple emulsions in skin care cosmetics Chunfang Zhu, Junbiao Li, Zhenming Xie 2024, 54 (10):  1243-1250.  doi: 10.3969/j.issn.2097-2806.2024.10.012 Abstract ( 1793 )   HTML ( 7 )   PDF (6540KB) ( 71 )   The multiple emulsion system is an emulsification system with a special structure in the cosmetic formulation process. It can improve the stability and safety of cosmetic functional ingredients, improve the skin feel of traditional emulsions, and achieve synergistic encapsulation and sustained release of different functional ingredients. It has received more and more widespread attention in the field of cosmetics and has become a research hotspot of cosmetic emulsification systems. In formula design and practical application, multiple emulsions are not widely used in the actual production process of cosmetics due to their complex structure, poor stability, difficulty in preparation, and high requirements for actual production process application. This article first introduces multiple emulsions and their characteristic structures, then explains the preparation methods and factors affecting stability of multiple emulsions, providing ideas for solving the stability problems of multiple emulsions. Finally, it outlines the application of different types of multiple emulsions in skin care cosmetics, and looks forward to the application prospects of multiple emulsions. It aims to provide a theoretical basis for the preparation and application of multiple emulsions in skin care cosmetics. Figures and Tables | References | Related Articles | Metrics

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Hair follicle and scalp problems and their countermeasures Feng Liu, Tingting Han, Qingwen Jia, Suzhen Yang, Zhijuan Hu, Qianqian Sun 2024, 54 (10):  1251-1259.  doi: 10.3969/j.issn.2097-2806.2024.10.013 Abstract ( 90 )   HTML ( 8 )   PDF (7516KB) ( 58 )   Hair follicles are tiny epithelial organs on the scalp that are complex and cyclical in structure. Hair follicles play an important role in the scalp. Each hair follicle is an independent hair production factory. Healthy hair follicles play a key role in the good maintenance of the scalp and hair, and hair follicles are non-renewable. When hair follicles shrink or become blocked due to genetics, androgens, stress and other factors, it can lead to a series of scalp problems. At present, there are extensive researches related to hair follicle biology at home and abroad, but there are few reports linking various scalp problems with hair follicles. This paper mainly reviews the correlation between the occurrence of various scalp problems such as dandruff, androgen alopecia, folliculitis and hair follicles, and summarizes the mechanism of various scalp problems from the perspective of hair follicles and provides corresponding solutions. It points out the direction of scientific scalp care. Figures and Tables | References | Related Articles | Metrics

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Advances in laboratory methods for testing whitening efficacy of oral care products Han Qiao, Mengxuan Wu, Zihang Liu, Shujun Cheng 2024, 54 (10):  1260-1267.  doi: 10.3969/j.issn.2097-2806.2024.10.014 Abstract ( 101 )   HTML ( 7 )   PDF (6933KB) ( 50 )   The whitening effect of oral care products refers to the whitening effect achieved by removing stains, pigments and plaque on the surface of teeth. Commonly used oral whitening care products include whitening toothpaste, mouthwash, whitening tooth strips, whitening gels, etc. It is evident that whitening effect remains the primary concern of consumers from the market share of oral care products. At home and abroad, there are numerous reports of false advertising and exaggerated efficacy of oral care products for whitening, which trigger high social attention and affect the development of oral care industry. Therefore, the establishment of a complete efficacy evaluation system not only meets the market demand, but also helps to improve the scientific supervision level of products with whitening efficacy claims. The design principles, experimental procedures, detection techniques and result analyses of laboratory methods for assessing the whitening efficacy of oral care products are reviewed, focusing on both domestic and international approaches. The four dimensions of model preparation, staining method, whitening process and application evaluation are compared to standardize the whitening efficacy assessment methods for oral care products. Scientific and rigorous standardization suggestions are put forward, which provide data support for the establishment of a complete set of laboratory methods for efficacy testing of oral whitening care products. Figures and Tables | References | Related Articles | Metrics

Analytical methods and testing

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Simultaneous determination of seven isothiazolinone preservatives in rinse-off cosmetics by HPLC and verification by HPLC-MS/MS Cen Chen, Beizhou Cui, Liyuan Zhang, Linqi Yan, Qiaoyuan Cheng 2024, 54 (10):  1268-1275.  doi: 10.3969/j.issn.2097-2806.2024.10.015 Abstract ( 78 )   HTML ( 5 )   PDF (5983KB) ( 46 )   An analytical method for the simultaneous determination of seven isothiazolinone preservatives in rinse-off cosmetics by high-performance liquid chromatography （HPLC） and verification by liquid chromatography-tandem mass spectrometry （HPLC-MS/MS） was established. The cream and liquid cosmetic samples were ultrasonically extracted with methanol, centrifuged, and the supernatant was filtered through a microporous membrane for determination. The separation was executed on a CAPCELL PAK C18 MGIII column by gradient elution at a flow rate of 1.0 mL/min with methanol and 0.1% （V/V） phosphoric acid aqueous solution as the mobile phases. The column temperature was set at 40 ℃. The wavelengths of detection were 278, 282 and 319 nm. The results of high performance liquid chromatography were used for qualitative screening, the standard curve method was used for quantification, and the results of liquid chromatography tandem mass spectrometry were used for verification. The results show that the linear ranges of the seven isothiazolinone preservatives are 0.1-50 mg/L, and the correlation coefficients are all greater than 0.999 9. The average recoveries are 97.5%-109.9% （for cream） and 95.6%-103.6% （for liquid）, and the relative standard deviations （RSD） are bellow 3.0% at low, medium and high spiked levels. The detection limits are 0.05-0.11 mg/kg. The method is simple, rapid and accurate for the simultaneous determination and verification of seven isothiazolinone preservatives in the rinse-off cosmetics. Figures and Tables | References | Related Articles | Metrics

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Determination of 108 illegally added compounds in cosmetics and disinfectants by UPLC-Q-TOF-MS Xuenian Liu, Yixiang Lu, Keming Zhang, Aijun Jiao 2024, 54 (10):  1276-1288.  doi: 10.3969/j.issn.2097-2806.2024.10.016 Abstract ( 58 )   HTML ( 4 )   PDF (9768KB) ( 39 )   An ultra-performance liquid chromatography-quadrupole-time of flight mass spectrometry method （UPLC-Q-TOF-MS） was established to identify 108 illegally added compounds in cosmetic and disinfectants. Samples were dispersed in a saturated sodium chloride solution, extracted by sonication with acetonitrile solution containing 0.05% formic acid, and frozen at 0 ℃ while centrifuged. Chromatographic separation was performed on a X-Bridge C18 column （4.6 mm×100 mm, 3.5 μm） with gradient elution using 0.1% （volume fraction） acetic acid aqueous solution and acetonitrile as the mobile phases. The mass spectrum information of the tested compounds was collected by broadband collision-induced dissociation （bbCID） mode under the electrospray ion source and positive and negative ion scanning mode, and a screening database of 108 illegally added compounds was constructed. The effect of extraction solvent was investigated and the chromatographic and mass spectrometry conditions were optimized. The matrix effects and recovery of gel-, cream-, and powder-based cosmetics were also investigated. The results show that the detection limit of 108 compounds is 0.05-2.25 mg/kg, and the limit of quantification is 0.15-7.50 mg/kg. The correlation coefficient （R2） are greater than 0.99 in the corresponding liner concentration range. Average recoveries are in the range of 60.0%-122.1% at three spiked levels, and the relative standard deviations （RSDs） are 1.2%-23.3%. A total of 83 cosmetics and 50 antibacteriostatic samples are analyzed by this established method. Finally, lincomycin and lidocaine are detected in two batches of disinfection products. The contents of lincomycin and lidocaine are 5 024.4 mg/kg and 2.2 mg/kg, respectively. The optimized method is simple, accurate and suitable for rapid screening and simultaneous quantitative analysis of various illegally added compounds in cosmetics and disinfectants. Figures and Tables | References | Related Articles | Metrics