毛囊与头皮问题及其对策

doi:10.3969/j.issn.2097-2806.2024.10.013

Abstract

Abstract:

Hair follicles are tiny epithelial organs on the scalp that are complex and cyclical in structure. Hair follicles play an important role in the scalp. Each hair follicle is an independent hair production factory. Healthy hair follicles play a key role in the good maintenance of the scalp and hair, and hair follicles are non-renewable. When hair follicles shrink or become blocked due to genetics, androgens, stress and other factors, it can lead to a series of scalp problems. At present, there are extensive researches related to hair follicle biology at home and abroad, but there are few reports linking various scalp problems with hair follicles. This paper mainly reviews the correlation between the occurrence of various scalp problems such as dandruff, androgen alopecia, folliculitis and hair follicles, and summarizes the mechanism of various scalp problems from the perspective of hair follicles and provides corresponding solutions. It points out the direction of scientific scalp care.

Key words: hair follicles, scalp problems, treatment strategy

CLC Number:

TQ658

Feng Liu, Tingting Han, Qingwen Jia, Suzhen Yang, Zhijuan Hu, Qianqian Sun. Hair follicle and scalp problems and their countermeasures[J].China Surfactant Detergent & Cosmetics, 2024, 54(10): 1251-1259.

Figures/Tables 6

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References 54

[1]	Zheng Min, Lv Zhongfa. Research progress of skin hair follicles[J]. Journal of Zhejiang University (Med Edition), 2004 (4) : 4-7.
[2]	Wang Ning, Rong Enguang, Yan Xiaohong. Hair follicle development and production of research progress[J]. Journal of Northeast Agricultural University, 2012, 43 (9): 8.
[3]	Li Haiyang, Lin Quanran, Liu Qingmei, et al. Microbiota and scalp hair disease correlation research progress[J]. Chinese Dermatology Journal, 2023, 56 (7) : 686-688.
[4]	Susan L Limbu, Purba T, Harries M, et al. A folliculocentric perspective of dandruff pathogenesis: Could a troublesome condition be caused by changes to a natural secretory mechanism?[J]. BioEssays, 2021, 43 (10): 2100005.
[5]	Luelmo-Aguilar J, Santandreu M S. Folliculitis: recognition and management[J]. American Journal of Clinical Dermatology, 2004, 5: 301-310. doi: 10.2165/00128071-200405050-00003 pmid: 15554731
[6]	Kim S, Shin S, Kim S N, et al. Understanding the characteristics of the scalp for developing scalp care products[J]. Journal of Cosmetics, Dermatological Sciences and Applications, 2021, 11 (3) : 204-216.
[7]	Paus R, Foitzik K. In search of the “hair cycle clock”: a guided tour[J]. Differentiation, 2004, 72 (9/10) : 489-511.
[8]	Borda L J, Wikramanayake T C. Seborrheic dermatitis and dandruff: a comprehensive review[J]. Journal of Clinical and Investigative Dermatology, 2015, 3 (2): 10.
[9]	Gupta A, Bluhm R. Seborrheic dermatitis[J]. Journal of the European Academy of Dermatology and Venereology, 2004, 18 (1) : 13-26. doi: 10.1111/j.1468-3083.2004.00693.x pmid: 14678527
[10]	Piraccini B, Alessandrini A. Androgenetic alopecia[J]. Giornale Italiano Di Dermatologia E Venereologia: Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia, 2014, 149 (1) : 15-24.
[11]	Honnavar P, Prasad G S, Ghosh A, et al. Malassezia arunalokei sp. nov., a novel yeast species isolated from seborrheic dermatitis patients and healthy individuals from India[J]. Journal of Clinical Microbiology, 2016, 54 (7) : 1826-1834.
[12]	Park T, Kim H J, Myeong N R, et al. Collapse of human scalp microbiome network in dandruff and seborrhoeic dermatitis[J]. Experimental Dermatology, 2017, 26 (9) : 835-838. doi: 10.1111/exd.13293 pmid: 28094891
[13]	Park M, Cho Y J, Lee Y W, et al. Understanding the mechanism of action of the anti-dandruff agent zinc pyrithione against Malassezia restricta[J]. Scientific Reports, 2018, 8 (1) : 1-11.
[14]	Ou W, Shen J, Zhong J, et al. Rapid on-site detection of zinc pyrithione in real-life samples with unprecedented selectivity and sensitivity[J]. Sensors and Actuators B: Chemical, 2023, 378: 133129.
[15]	Chen Dongzhi, Xu Mingli, Huo Yanli. Research overview of the mild anti-dandruff agent piroxone ethanolamine salt[J]. Chemicals for Daily Use, 2021, 44 (5) : 40-44.
[16]	Wall I, Schmidt-Wolf I G. Effect of Wnt inhibitors in pancreatic cancer[J]. Anticancer Research, 2014, 34 (10) : 5375-5380. pmid: 25275031
[17]	Dessinioti C, Katsambas A. Seborrheic dermatitis: etiology, risk factors, and treatments: facts and controversies[J]. Clinics in Dermatology, 2013, 31 (4) : 343-351.
[18]	Satchell A C, Saurajen A, Bell C, et al. Treatment of dandruff with 5% tea tree oil shampoo[J]. Journal of the American Academy of Dermatology, 2002, 47 (6) : 852-855. pmid: 12451368
[19]	Limbu S L, Purba T S, Harries M, et al. A folliculocentric perspective of dandruff pathogenesis: Could a troublesome condition be caused by changes to a natural secretory mechanism?[J]. BioEssays, 2021, 43 (10): 2100005.
[20]	Soares R C, Camargo-Penna P H, de Moraes V, et al. Dysbiotic bacterial and fungal communities not restricted to clinically affected skin sites in dandruff[J]. Frontiers in Cellular and Infection Microbiology, 2016: 157.
[21]	Mills K, Hu P, Henry J, et al. Dandruff/seborrhoeic dermatitis is characterized by an inflammatory genomic signature and possible immune dysfunction: transcriptional analysis of the condition and treatment effects of zinc pyrithione[J]. British Journal of Dermatology, 2012, 166 (S2) : 33-40.
[22]	Pople J, Bhogal R, Moore A, et al. Changes in epidermal morphology associated with dandruff[J]. International Journal of Cosmetic Science, 2019, 41 (4) : 357-363. doi: 10.1111/ics.12539 pmid: 31087801
[23]	Grimshaw S G, Smith A M, Arnold D S, et al. The diversity and abundance of fungi and bacteria on the healthy and dandruff affected human scalp[J]. PLoS One, 2019, 14 (12): e0225796.
[24]	Dawson Jr T L. Malassezia globosa and restricta: breakthrough understanding of the etiology and treatment of dandruff and seborrheic dermatitis through whole-genome analysis[J]. Journal of Investigative Dermatology Symposium Proceedings, 2007, 12 (2) : 15-19.
[25]	Nagao K, Kobayashi T, Moro K, et al. Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin[J]. Nature Immunology, 2012, 13 (8) : 744-752. doi: 10.1038/ni.2353 pmid: 22729248
[26]	Cruz C F, Costa C, Gomes A C, et al. Human hair and the impact of cosmetic procedures: a review on cleansing and shape-modulating cosmetics[J]. Cosmetics, 2016, 3 (3): 26.
[27]	Price V H. Treatment of hair loss[J]. New England Journal of Medicine, 1999, 341 (13) : 964-973. doi: 10.1056/NEJM199909233411307 pmid: 10498493
[28]	Ellis J A, Sinclair R, Harrap S B. Androgenetic alopecia: pathogenesis and potential for therapy[J]. Expert Reviews in Molecular Medicine, 2002, 4 (22) : 1-11. doi: 10.1017/S1462399402005112 pmid: 14585162
[29]	Jahoda C. Cellular and developmental aspects of androgenetic alopecia[J]. Experimental Dermatology, 1998, 7 (5) : 235-248. pmid: 9832312
[30]	Blanpain C, Lowry W E, Geoghegan A, et al. Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche[J]. Cell, 2004, 118 (5) : 635-648. doi: 10.1016/j.cell.2004.08.012 pmid: 15339667
[31]	Paus R, Cotsarelis G. The biology of hair follicles[J]. New England Journal of Medicine, 1999, 341 (7) : 491-497. pmid: 10441606
[32]	Hibberts N, Howell A, Randall V. Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp[J]. Journal of Endocrinology, 1998, 156: 59-65. doi: 10.1677/joe.0.1560059 pmid: 9496234
[33]	Roh C, Tao Q, Lyle S. Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin[J]. Physiological Genomics, 2004, 19 (2) : 207-217. doi: 10.1152/physiolgenomics.00134.2004 pmid: 15292489
[34]	Randall V, Thornton M, Messenger A. Cultured dermal papilla cells from androgen-dependent human hair follicles (eg beard) contain more androgen receptors than those from non-balding areas of scalp[J]. Journal of Endocrinology, 1992, 133 (1) : 141-147. pmid: 1517703
[35]	Shamma R N, Aburahma M H. Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia[J]. International Journal of Nanomedicine, 2014: 5449-5460.
[36]	Essam R, Selim H, Ehab R. The boosting effect of minoxidil 0.1% when combined with dutasteride 0.01% and microneedling in the treatment of female pattern hair loss[J]. Journal of the Egyptian Women’s Dermatologic Society, 2024, 21 (1) : 29-35.
[37]	Rossi A, Anzalone A, Fortuna M C, et al. Multi-therapies in androgenetic alopecia: Review and clinical experiences[J]. Dermatologic Therapy, 2016, 29 (6) : 424-432. doi: 10.1111/dth.12390 pmid: 27424565
[38]	Blume-Peytavi U, Lönnfors S, Hillmann K, et al. A randomized double-blind placebo-controlled pilot study to assess the efficacy of a 24-week topical treatment by latanoprost 0.1% on hair growth and pigmentation in healthy volunteers with androgenetic alopecia[J]. Journal of the American Academy of Dermatology, 2012, 66 (5) : 794-800. doi: 10.1016/j.jaad.2011.05.026 pmid: 21875758
[39]	Park P J, Mondal H, Pi B S, et al. The effect of oxygen supply using perfluorocarbon-based nanoemulsions on human hair growth[J]. Journal of Materials Chemistry B, 2024, 12 (4) : 991-1000. doi: 10.1039/d3tb02237d pmid: 38193597
[40]	Khutsishvili N, Rudnicka L, Ovcharenko Y, et al. Trichoscopy: a valuable tool for identifying conditions mimicking androgenetic alopecia[J]. International Journal of Dermatology, 2024, 63 (1) : 23-31.
[41]	Katzer T, Leite Junior A, Beck R, et al. Physiopathology and current treatments of androgenetic alopecia: Going beyond androgens and anti-androgens[J]. Dermatologic Therapy, 2019, 32 (5): e13059.
[42]	Williams R, Pawlus A D, Thornton M J. Getting under the skin of hair aging: the impact of the hair follicle environment[J]. Experimental Dermatology, 2020, 29 (7) : 588-597.
[43]	Naito A, Midorikawa T, Yoshino T, et al. Lipid peroxides induce early onset of catagen phase in murine hair cycles[J]. International Journal of Molecular Medicine, 2008, 22 (6) : 725-729. pmid: 19020769
[44]	Akar A, Arca E, Erbil H, et al. Antioxidant enzymes and lipid peroxidation in the scalp of patients with alopecia areata[J]. Journal of Dermatological Science, 2002, 29 (2) : 85-90. doi: 10.1016/s0923-1811(02)00015-4 pmid: 12088608
[45]	Suzuki T, Scala F, Demetrius D L, et al. IL-15 prolongs anagen, stimulates proliferation, and suppresses apoptosis in the hair matrix of human scalp hair follicles[J]. The Journal of Investigative Dermatology, 2024, 144 (1) : 165-170.
[46]	Rivera-Gonzalez G, Shook B, Horsley V. Adipocytes in skin health and disease[J]. Cold Spring Harbor Perspectives in Medicine, 2014, 4 (3): a015271.
[47]	Rivera-Gonzalez G C, Shook B A, Andrae J, et al. Skin adipocyte stem cell self-renewal is regulated by a PDGFA/AKT-signaling axis[J]. Cell Stem Cell, 2016, 19 (6) : 738-751. doi: S1934-5909(16)30296-X pmid: 27746098
[48]	Kumar V, Cotran R S, Robbins S L. Basic pathology[J]. Philadelphia, 1997, 5: 25-40.
[49]	Matsumura H, Mohri Y, Binh N T, et al. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis[J]. Science, 2016, 351 (6273): 4395. doi: 10.1126/science.aad4395 pmid: 26912707
[50]	Basarab T, Jones R R. HIV-associated eosinophilic folliculitis: case report and review of the literature[J]. British Journal of Dermatology, 1996, 134 (3) : 499-503. pmid: 8731676
[51]	Laureano A C, Schwartz R A, Cohen P J. Facial bacterial infections: folliculitis[J]. Clinics in Dermatology, 2014, 32 (6) : 711-714.
[52]	Hald M, Arendrup M C, Svejgaard E L, et al. Evidence-based Danish guidelines for the treatment of Malassezia-related skin diseases[J]. Acta Dermato-Venereologica, 2015, 95 (1) : 12-19.
[53]	Vipinsha R, Thilak A. An Ayurveda protocol for the management of hair loss due to dandruff: A conceptual study[J]. 2021, 8 (4): 9.
[54]	Ji S, Zhu Z, Sun X, et al. Functional hair follicle regeneration: an updated review[J]. Signal Transduction and Targeted Therapy, 2021, 6 (1): 66. doi: 10.1038/s41392-020-00441-y pmid: 33594043

Hair follicle and scalp problems and their countermeasures

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