关键词: 表面活性剂, 微乳液, 磷脂, 拟三元相图, 白藜芦醇, 稳定性

Abstract:

An O/W microemulsion （ME） was prepared by compounding soybean phospholipids and alkylglycoside sodium hydroxypropyl sulfonate （APGSHS） as the emulsifiers in a 2∶1 ratio. The optimal formulation was determined by the ternary phase diagram method: 1, 2-hexanediol as the co-surfactant, dibutyl adipate as the oil phase, the mass ratio of the complex surfactant to the co-surfactant （K_m） of 1∶2, the mass fraction of dibutyl adipate in the system of 8.00%, and the amount of water added of 60.00%, and the concentration of inorganic salts in the water of 0.1 mol/L.Transmission electron microscopy show that the microemulsion is spherical, with oil droplets uniformly distributed, and the particle size is 15-25 nm. The maximum loading of the system for resveratrol is （11.55±0.14） mg/mL, which shows a good solubilization effect. At 1.00% resveratrol loading, the microemulsion shows good stabilization effect, with a retention rate of 77.13%±0.51% after 28 days of storage at 50 ℃, which is 19.21% higher than that of the unwrapped one, and a retention rate of 57.21%±0.32% after 32 h of storage at 365 nm UV illumination, which is 20.72% higher than that of the unwrapped one. The transdermal permeation amount of resveratrol in this system is up to （461.12±35.01）μg/cm² for 24 h, which has a good osmotic effect on insoluble polyphenolic compounds.

Key words: surfactant, microemulsion, phospholipid, proposed ternary phase diagram, resveratrol, stability