益智精油O/W型微乳液的制备及其性能研究

doi:10.3969/j.issn.2097-2806.2024.10.007

摘要/Abstract

摘要：

益智（Alpinia oxyphylla Miq.）提取物是一种天然的化妆品原料，可作为植物功能油使用。为了获得稳定的益智精油（AOEO）水包油型（O/W型）微乳液，本研究通过拟三元相图法构建含AOEO的O/W型微乳液，考察表面活性剂、助表面活性剂、K_m（表面活性剂与助表面活性剂的质量比）以及其不同组分及比例对微乳液面积的影响，并测定微乳液的粒径、形貌、电导率、水溶性及稳定性等指标，探讨其表征与理化性能。结果得到益智精油O/W型微乳液的较优配方为：m（蓖麻油聚氧乙烯醚40（EL-40）） ∶m（1,2-丙二醇） ∶m（AOEO）=10.5∶3.5∶6，水相的过渡点为60%（质量分数），平均粒径为（26.580±0.133） nm，多分散指数（PDI）为0.226±0.010，在透射电子显微镜（TEM）与数码生物显微镜（DBM）下微乳液呈球形或类球形，规整，无黏边，并具有良好的水溶性、离心稳定性、热稳定性及低温贮藏稳定性。结果表明以微乳液为载体可实现益智精油的纳米包覆，为益智精油在日化领域的开发与应用提供参考。

关键词: 益智精油, 微乳液, 拟三元相图, 蓖麻油聚氧乙烯醚, O/W型

Abstract:

Alpinia oxyphylla Miq. extract is a kind of natural cosmetic raw material, which can be used as plant functional oil. In order to obtain a stable O/W microemulsion of Alpinia oxyphylla Miq. essential oil（AOEO）, the O/W microemulsion containing AOEO was constructed by pseudo ternary phase diagram method. The effects of surfactants, cosurfactants, K_m （mass ratio of surfactant to cosurfactant）, and their different components and ratios on the area of the microemulsion were investigated. The particle size, morphology, conductivity, water solubility and stability of the microemulsion were measured, and its characterization and physicochemical properties were discussed. The results show that the optimal formula of O/W microemulsion of AOEO is obtained as follows: m（castor oil polyoxyethylene ether 40 （EL-40）） ∶m（1,2-propylene glycol） ∶m（AOEO）=10.5∶3.5∶6, the transition point of O/W microemulsion is 60% （mass fraction）. The average particle size of the O/W microemulsion is （26.580±0.133） nm, the polydispersion index （PDI） is 0.226±0.010, and the microemulsion is slightly spherical or quasi-spherical, regular, and without adhering edges under transmission electron microscopy （TEM） and digital biological microscopy （DBM）. The microemulsion has good water solubility, centrifugal stability, thermal stability and low temperature storage stability. The results show that the nano-coating of AOEO can be realized by using microemulsion as carrier, which provides reference for the development and application of AOEO in daily chemical field.

Key words: Alpinia oxyphylla Miq. essential oil, microemulsion, pseudo ternary phase diagram, castor oil polyoxyethylene ether, O/W

中图分类号:

TQ658

谢小丽, 胡璇, 黄英, 王凯, 王丹, 于福来. 益智精油O/W型微乳液的制备及其性能研究[J]. 日用化学工业（中英文）, 2024, 54(10): 1201-1210.

Xiaoli Xie, Xuan Hu, Ying Huang, Kai Wang, Dan Wang, Fulai Yu. Preparation and properties of O/W microemulsion of Alpinia oxyphylla Miq. essential oil[J]. China Surfactant Detergent & Cosmetics, 2024, 54(10): 1201-1210.

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表面活性剂	HLB值	乳液外观
司盘80	4.3	分层
吐温80	15	不分层
吐温60	14.5	不分层
吐温20	16.5	分层
OP-10	14.5	不分层
EL-40	13~14	不分层
APG0810	15~16	分层
曲通X-100	14.5	不分层

S_mix	平均粒径/nm	PDI	外观
9∶1	32.87±2.70^c	0.272±0.005^c	澄清透明，久置1年不分层
8∶2	21.17±0.55^a	0.09±0.03^a	澄清透明，久置1年不分层
7∶3	26.580±0.133^ab	0.226±0.010^b	澄清透明，久置1年不分层

离心速率/ （r/min）	益智精油微乳液
离心速率/ （r/min）	透光率%	形态变化
2 000	99.52	黄色澄清透明、无分层或浑浊
4 000	98.86	黄色澄清透明、无分层或浑浊
6 000	97.31	黄色澄清透明、无分层或浑浊
8 000	95.86	黄色澄清透明、无分层或浑浊
10 000	95.17	黄色澄清透明、无分层或浑浊