白藜芦醇在皮肤修复领域的应用研究进展

doi:10.3969/j.issn.2097-2806.2025.12.011

摘要/Abstract

摘要：

白藜芦醇是一种广泛存在于植物中的多酚化合物，因其显著的抗氧化、抗炎和促进皮肤修复的特性而受到越来越多的关注。皮肤作为人体最大的器官，其修复过程对于维护整体健康至关重要。然而，随着环境污染、紫外线辐射及年龄增长等因素的影响，皮肤损伤和衰老问题日益严重。因此，探索有效的皮肤修复策略显得尤为重要。近年来，研究表明白藜芦醇能够通过多种机制促进皮肤的自我修复，包括增强细胞增殖、促进胶原蛋白合成以及调节炎症反应等。该文旨在通过综述相关文献，深入分析白藜芦醇在皮肤修复中的机制及应用前景，为其在皮肤损伤的治疗方面提供参考。

关键词: 白藜芦醇, 皮肤修复, 抗氧化, 抗炎, 皮肤护理

Abstract:

Resveratrol is a polyphenolic compound widely found in plants, which has been gaining more attention for its significant antioxidant, anti-inflammatory, and skin repair-promoting properties. As the largest organ in the human body, the skin plays a crucial role in maintaining overall health through its repair process. However, skin damage and aging are becoming increasingly serious with the effects of environmental pollution, ultraviolet radiation, and other factors. Therefore, it is particularly important to explore effective skin repair strategies. In recent years, studies have shown that resveratrol can promote skin self-repair through multiple mechanisms, including enhancing cell proliferation, promoting collagen synthesis, and modulating inflammatory responses. The aim of this paper is to analyze in depth the mechanism and application prospects of resveratrol in skin repair by reviewing the existing literature, so as to provide a reference for its use in the treatment of skin injury.

Key words: resveratrol, skin repair, antioxidant, anti-inflammatory, skin care

中图分类号:

TQ658

李佳宁, 冯淑瑶, 张淳, 葛朝晖, 高振珅, 张海娟. 白藜芦醇在皮肤修复领域的应用研究进展[J]. 日用化学工业（中英文）, 2025, 55(12): 1582-1588.

Jianing Li, Shuyao Feng, Chun Zhang, Zhaohui Ge, Zhenshen Gao, Haijuan Zhang. Research progress of resveratrol in skin repair application[J]. China Surfactant Detergent & Cosmetics, 2025, 55(12): 1582-1588.

图/表 4

参考文献 43

[1]	Abo-Kadoum M A, Abouelela M E, Al Mousa A A, et al. Resveratrol biosynthesis, optimization, induction, bio-transformation and bio-degradation in mycoendophytes[J]. Frontiers in Microbiology, 2022, 13: 1010332. doi: 10.3389/fmicb.2022.1010332
[2]	Qi L, Zhang C, Wang B, et al. Progress in hydrogels for skin wound repair[J]. Macromolecular Bioscience, 2022, 22 (7) : 2100475. doi: 10.1002/mabi.v22.7
[3]	Garcia N, Lau L D W, Lo C H, et al. Understanding the mechanisms of spontaneous and skin-grafted wound repair: the path to engineered skin grafts[J]. Journal of Wound Care, 2023, 32 (1) : 55-62. doi: 10.12968/jowc.2023.32.1.55 pmid: 36630112
[4]	Zachary C M, Wang J V, Saedi N. Resveratrol as a skincare ingredient: current evidence and the future potential[J]. Skinmed, 2021, 19 (6) : 414-416.
[5]	Xia S, Yan C, Gu J, et al. Resveratrol alleviates zearalenone-induced intestinal dysfunction in mice through the NF-κB/Nrf2/HO-1 signalling pathway[J]. Foods, 2024, 13 (8) : 1217. doi: 10.3390/foods13081217
[6]	Spósito L, Morais-Silva G, Fonseca D, et al. Nano-in-microparticles approach: Targeted gastric ulcer therapy using trans-resveratrol nanoparticles encapsulated in hyaluronic acid and alginate microparticles[J]. International Journal of Biological Macromolecules, 2025: 141010.
[7]	张静静, 姚明, 李立, 等. 白藜芦醇, 白皮杉醇和赤松素的合成[J]. 有机化学, 2020, 40 (4) : 1062. doi: 10.6023/cjoc201908014
[8]	Kobayashi Y, Inokuma K, Matsuda M, et al. Resveratrol production from several types of saccharide sources by a recombinant Scheffersomyces stipitis strain[J]. Metabolic Engineering Communications, 2021, 13: e00188. doi: 10.1016/j.mec.2021.e00188
[9]	Zhang M, Gao Q, Liu Y, et al. Metabolic engineering of Rhodotorula toruloides for resveratrol production[J]. Microbial Cell Factories, 2022, 21 (1) : 270. doi: 10.1186/s12934-022-02006-w
[10]	赵莹. 代谢工程大肠杆菌合成白藜芦醇[D]. 天津: 天津大学, 2019.
[11]	D’Amico E, Cinquini C, Petrini M, et al. The application of resveratrol derivatives in oral cells reduces the oxidative stress induced by glucocorticoids[J]. Metabolites, 2024, 14 (7) : 350. doi: 10.3390/metabo14070350
[12]	Bilski R, Kupczyk D, Woźniak A. Oxidative imbalance in psoriasis with an emphasis on osoriatic arthritis: Therapeutic antioxidant targets[J]. Molecules, 2024, 29 (22) : 5460. doi: 10.3390/molecules29225460
[13]	Cai M, Wang J, Sun H, et al. Resveratrol attenuates hydrogen peroxide-induced injury of rat ovarian granulosa-lutein cells by resisting oxidative stress via the SIRT1/Nrf2/ARE signaling pathway[J]. Current Pharmaceutical Design, 2023, 29 (12) : 947-956. doi: 10.2174/1381612829666230403133322 pmid: 37013424
[14]	Pourbagher-Shahri A M, Farkhondeh T, Jafari-Nozad A M, et al. Nrf2 mediates effect of resveratrol in ischemia-reperfusion injury[J]. Current Molecular Pharmacology, 2024, 17 (1) : e18761429246578.
[15]	Shi Z, Jiao Y, Lai Z, et al. Evaluation of the protective role of resveratrol on LPS-induced septic intestinal barrier function via TLR4/MyD88/NF-κB signaling pathways[J]. Scientific Reports, 2025, 15 (1) : 828. doi: 10.1038/s41598-025-85148-2
[16]	Chen S, Tamaki N, Kudo Y, et al. Protective effects of resveratrol against 5-fluorouracil-induced oxidative stress and inflammatory responses in human keratinocytes[J]. Journal of Clinical Biochemistry and Nutrition, 2021, 69 (3) : 238. doi: 10.3164/jcbn.21-23 pmid: 34857985
[17]	Gezer A, Üstündağ H, Özkaraca M, et al. Therapeutic effects of resveratrol and β-carotene on L-arginine-induced acute pancreatitis through oxidative stress and inflammatory pathways in rats[J]. Scientific Reports, 2024, 14 (1) : 32068. doi: 10.1038/s41598-024-83764-y
[18]	Tufekci K U, Eltutan B I, Isci K B, et al. Resveratrol inhibits NLRP3 inflammasome-induced pyroptosis and miR-155 expression in microglia through Sirt1/AMPK pathway[J]. Neurotoxicity Research, 2021, 39 (6) : 1812-1829. doi: 10.1007/s12640-021-00435-w pmid: 34739715
[19]	Agbadua O G, Kúsz N, Berkecz R, et al. Oxidized resveratrol metabolites as potent antioxidants and xanthine oxidase inhibitors[J]. Antioxidants, 2022, 11 (9) : 1832. doi: 10.3390/antiox11091832
[20]	Zhang B, Xu Y, Lv H, et al. Intestinal pharmacokinetics of resveratrol and regulatory effects of resveratrol metabolites on gut barrier and gut microbiota[J]. Food Chemistry, 2021, 357: 129532. doi: 10.1016/j.foodchem.2021.129532
[21]	Liu Y, Xiong W, Wang C W, et al. Resveratrol promotes skin wound healing by regulating the miR-212/CASP8 axis[J]. Laboratory Investigation, 2021, 101 (10) : 1363-1370. doi: 10.1038/s41374-021-00621-6 pmid: 34234270
[22]	Kanaujiya S, Arya D K, Pandey P, et al. Resveratrol-ampicillin dual-drug loaded polyvinylpyrrolidone/polyvinyl alcohol biomimic electrospun nanofiber enriched with collagen for efficient burn wound repair[J]. International Journal of Nanomedicine, 2024: 5397-5418.
[23]	Li L, Chen X, Liu C, et al. Endogenous hydrogen sulphide deficiency and exogenous hydrogen sulphide supplement regulate skin fibroblasts proliferation via necroptosis[J]. Experimental Dermatology, 2024, 33 (1) : e14972. doi: 10.1111/exd.v33.1
[24]	Ashrafizadeh M, Najafi M, Orouei S, et al. Resveratrol modulates transforming growth factor-beta (TGF-β) signaling pathway for disease therapy: a new insight into its pharmacological activities[J]. Biomedicines, 2020, 8 (8) : 261. doi: 10.3390/biomedicines8080261
[25]	Khazaei M, Rahmati S, Khazaei M R, et al. Accelerated wound healing with resveratrol-loaded decellularized pericardium in mice model[J]. Cell and Tissue Banking, 2024, 25 (1) : 245-253. doi: 10.1007/s10561-023-10117-w
[26]	Boo Y C. Human skin lightening efficacy of resveratrol and its analogs: from in vitro studies to cosmetic applications[J]. Antioxidants, 2019, 8 (9) : 332. doi: 10.3390/antiox8090332
[27]	Zhang X, Chen S, Luo D, et al. Systematic study of resveratrol nanoliposomes transdermal delivery system for enhancing anti-aging and skin-brightening efficacy[J]. Molecules, 2023, 28 (6) : 2738. doi: 10.3390/molecules28062738
[28]	Markiewicz E, Jerome J, Mammone T, et al. Anti-glycation and anti-aging properties of resveratrol derivatives in the in-vitro 3D models of human skin[J]. Clinical, Cosmetic and Investigational Dermatology, 2022: 911-927.
[29]	Lin M H, Hung C F, Sung H C, et al. The bioactivities of resveratrol and its naturally occurring derivatives on skin[J]. Journal of Food and Drug Analysis, 2021, 29 (1) : 15. doi: 10.38212/2224-6614.1151
[30]	Shin J W, Lee H S, Na J I, et al. Resveratrol inhibits particulate matter-induced inflammatory responses in human keratinocytes[J]. International Journal of Molecular Sciences, 2020, 21 (10) : 3446. doi: 10.3390/ijms21103446
[31]	Xia Y, Zhang H, Wu X, et al. Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway[J]. Biogerontology, 2024, 25 (4) : 649-664. doi: 10.1007/s10522-024-10099-6 pmid: 38592565
[32]	Kang M C, Cho K, Lee J H, et al. Effect of resveratrol-enriched rice on skin inflammation and pruritus in the NC/Nga mouse model of atopic dermatitis[J]. International Journal of Molecular Sciences, 2019, 20 (6) : 1428. doi: 10.3390/ijms20061428
[33]	Carlucci C D, Hui Y, Chumanevich A P, et al. Resveratrol protects against skin inflammation through inhibition of mast cell, sphingosine Kinase-1, Stat3 and NF-κB p65 signaling activation in mice[J]. International Journal of Molecular Sciences, 2023, 24 (7) : 6707. doi: 10.3390/ijms24076707
[34]	Riccio B V F, Nascimento A L C S, Meneguin A B, et al. Solid dispersions incorporated into PVP films for the controlled release of trans-resveratrol: development, physicochemical and in vitro characterizations and in vivo cutaneous anti-inflammatory evaluation[J]. Pharmaceutics, 2022, 14 (6) : 1149. doi: 10.3390/pharmaceutics14061149
[35]	付燚盈, 许文哲, 荣莉, 等. 白藜芦醇纳米颗粒结合可溶性微针用于瘢痕疙瘩治疗[J]. 高等学校化学学报, 2025, 46 (1) : 158-167.
[36]	Li B, Li X, Li S, et al. Supramolecular cyclodextrin deep eutectic solvent-strengthened chitosan eutectogel as a novel percutaneous delivery system of resveratrol for anti-psoriasis[J]. International Journal of Biological Macromolecules, 2025: 140156.
[37]	Kulka-Kamińska K, Kurzawa M, Sionkowska A. Films based on chitosan/konjac glucomannan blend containing resveratrol for potential skin application[J]. Materials, 2025, 18 (2) : 457. doi: 10.3390/ma18020457
[38]	Feng J, Wang Z, Li X, et al. Facile formulation of a resveratrol-mediated multibond metwork hydrogel with efficient sustainable antibacterial, reactive oxygen species scavenging, pro-angiogenesis, and immunomodulation activities for accelerating infected wound healing[J]. ACS Applied Materials & Interfaces, 2025, 17 (4) : 6144-6160.
[39]	Zhang X, Chen S, Luo D, et al. Systematic study of resveratrol nanoliposomes transdermal delivery system for enhancing anti-aging and skin-brightening efficacy[J]. Molecules, 2023, 28 (6) : 2738. doi: 10.3390/molecules28062738
[40]	Li W, Yu J, Li Q, et al. Bacterial cellulose nanofiber reinforced self-healing hydrogel to construct a theranostic platform of antibacterial and enhanced wound healing[J]. International Journal of Biological Macromolecules, 2024, 281: 136336. doi: 10.1016/j.ijbiomac.2024.136336
[41]	Feng C, Chen J, Ye W, et al. Synthetic biology-driven microbial production of resveratrol: advances and perspectives[J]. Frontiers in Bioengineering and Biotechnology, 2022, 10: 833920. doi: 10.3389/fbioe.2022.833920
[42]	Ben Dassi R, Ibidhi S, Jemai H, et al. Resveratrol: challenges and prospects in extraction and hybridization with nanoparticles, polymers, and bio-ceramics[J]. Phytotherapy Research, 2024, 38 (11) : 5309-5322. doi: 10.1002/ptr.8319 pmid: 39228146
[43]	Zhang Y, Zhang Q, Li C, et al. Advances in cell membrane-based biomimetic nanodelivery systems for natural products[J]. Drug Delivery, 2024, 31 (1) : 2361169. doi: 10.1080/10717544.2024.2361169