包裹阿伏苯宗的介孔硅稳定皮克林乳液用于增强防晒性能

doi:10.3969/j.issn.2097-2806.2025.12.003

摘要/Abstract

摘要：

有机防晒剂在减少晒伤、光老化和由紫外线辐射引起的皮肤癌风险中发挥着重要作用。然而，这些有机防晒剂的光降解除了会显著降低其紫外线保护效果外，其光降解产物可能渗透到角质层中，导致潜在的光毒性和光过敏反应，对皮肤造成伤害。更重要的是，一些有机防晒剂的疏水特性使其在传统配方中的分散性受到影响，从而限制了其紫外线屏蔽能力。该研究旨在通过原位溶胶-凝胶法将有机防晒剂阿伏苯宗（Avobenzone）封装在介孔硅（MPS）中，形成AB@MPS颗粒，并研究以其作为固体颗粒乳化剂稳定的Pickering乳液的防晒性能。研究结果表明，AB@MPS颗粒的紫外线吸收能力高于游离阿伏苯宗。在体外皮肤渗透测试中，AB@MPS减少了73.9%的阿伏苯宗渗透量。此外，AB@MPS颗粒的光稳定性约为游离阿伏苯宗的14.3倍。在紫外线保护测试中，Pickering乳液的抗UVA效能是20%丙二醇溶液的2.28倍，是卡波姆水凝胶的4.41倍，也是乳霜配方的3.59倍。Pickering乳液的SPF值比20%丙二醇溶液高出2.41倍，比卡波姆水凝胶高出2倍，比乳霜配方高出6.77倍。

关键词: 皮克林乳液, 介孔硅, 防晒, 光保护, 润湿性

Abstract:

Organic ultraviolet （UV） filters play a crucial role in reducing sunburn, photoaging, and the risk of skin cancer induced by UV radiation. However, the challenges posed by photodegradation, potential phototoxicity, and poor dispersion characteristics of organic UV filters significantly hinder their practical applications. This study aims to encapsulate avobenzone, a widely used UV filter, in mesoporous silica （MPS） to form AB@MPS particles via an in-situ sol-gel process, and to research their sunscreen performance as stabilizers in Pickering emulsion. The UV absorption capability of AB@MPS particles is stronger than free avobenzone. The in vitro skin penetration study reveals a greatly reduced permeability （73.9%） for avobenzone from AB@MPS compared to its free form. Furthermore, the photostability of AB@MPS particles increases 14.3 times compared to that of free avobenzone. In UV protection tests, the Pickering emulsion’s anti-UVA efficacy is 2.28 times greater than that of 20% PG solution, 4.41 times greater than Carbomer hydrogel, and 3.59 times greater than the cream formulation. The SPF value of the Pickering emulsion is 2.41 times greater than the 20% PG solution, 2 times greater than the Carbomer hydrogel, and 6.77 times greater than the cream formulation. This study presents a promising strategy for the application of Pickering emulsions in the cosmetic and pharmaceutical sectors, providing a safe and efficient formulation for sunscreens.

Key words: Pickering emulsion, mesoporous silica, sunscreen, photoprotection, wettability

中图分类号:

TQ658

黄启发, 谢雯, 郭晨龙, 陈娟博, 曾飒, 孟涛. 包裹阿伏苯宗的介孔硅稳定皮克林乳液用于增强防晒性能[J]. 日用化学工业（中英文）, 2025, 55(12): 1516-1525.

Qifa Huang, Wen Xie, Chenlong Guo, Juanbo Chen, Sa Zeng, Tao Meng. Pickering emulsion stabilized by avobenzone-loaded mesoporous particles for enhanced sunscreen performance[J]. China Surfactant Detergent & Cosmetics, 2025, 55(12): 1516-1525.

图/表 6

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Sample	Q24±S.D./ （μg/cm²）	Flux±S.D./ （μg/（cm²·h））
Avobenzone-hydrogel	7.24±1.26	0.30±0.05
AB@MPS-hydrogel	1.89±0.56	0.07±0.02