防晒类化妆品中二氧化钛纳米颗粒的筛查方法研究

doi:10.3969/j.issn.2097-2806.2025.04.004

摘要/Abstract

摘要：

建立了单颗粒电感耦合等离子体质谱快速筛查防晒类化妆品中二氧化钛纳米颗粒的检测方法，并采用高分辨透射电子显微镜联用能谱技术对其中纳米二氧化钛晶型进行了表征。以0.1% Triton X-100为萃取剂超声辅助提取化妆品中二氧化钛纳米颗粒，在时间分辨分析模式下采集脉冲信号，通过对采集的数据进行计算从而获得颗粒粒径大小及分布情况。结果表明：颗粒尺寸的检测限不仅受到待测元素同位素背景信号的影响，也与所采用的计算方法密切相关。不同的粒径检测限结果对被识别为颗粒的尺寸大小及数量浓度均有显著影响，直接关系到化妆品产品的合规性判定及安全性评价。防晒类化妆品中二氧化钛纳米颗粒快速筛查方法，为含纳米级材料化妆品的合规性和安全性考察提供了可供探讨的空间和途径。

关键词: 单颗粒电感耦合等离子体质谱法, 纳米二氧化钛, 背景阈值, 防晒类化妆品

Abstract:

A method was developed for the determination of particle size and distribution of titanium dioxide nanoparticles in sunscreen using single particle-inductively coupled plasma-mass spectrometry （spICP-MS）. The titanium dioxide nanoparticles were characterized by high resolution transmission electron microscopy （HRTEM） and energy dispersive spectroscopy （EDS）. 0.1% Triton X-100 was employed as an extractant for ultrasound-assisted extraction of titanium dioxide nanoparticles in cosmetics. The data were acquired in pulse signal mode, and the particle size and distribution were determined through calculation. The experimental results demonstrate that the lower limit of particle size detection is influenced not only by the background signal of the isotope to be detected but also by the cosmetic matrix. Different background thresholds significantly affect both the lower limit of particle size detection and the number of identified particles, thereby directly impacting compliance and safety considerations for cosmetics. This method enables rapid screening of titanium dioxide nanoparticles in sunscreen cosmetics while simultaneously determining and characterizing their particle size and distribution, providing a framework for discussing compliance and safety investigations regarding nanoparticle-containing cosmetics.

Key words: single particle inductively coupled plasma mass spectrometry （spICP-MS）, titanium dioxide nanoparticle （TiO₂-NP）, threshold criterion, sunscreen

中图分类号:

O657.63

李硕, 代静, 李庆武, 李莉. 防晒类化妆品中二氧化钛纳米颗粒的筛查方法研究[J]. 日用化学工业（中英文）, 2025, 55(4): 430-436.

Shuo Li, Jing Dai, Qingwu Li, Li Li. Research on screening methods for TiO₂ nanoparticles in sunscreen cosmetics[J]. China Surfactant Detergent & Cosmetics, 2025, 55(4): 430-436.

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阈值	检测限/nm	平均值/nm	中位值/nm	颗粒浓度（颗粒个数×10⁹/g）
3σ	63	71	67	3.6
4σ	70	80	75	1.3
5σ	76	90	82	0.56
7σ	85	106	100	0.22