大鲵肽的护肤功效研究及其应用

doi:10.3969/j.issn.2097-2806.2025.02.008

摘要/Abstract

摘要：

大鲵肽具有抗氧化、抗衰、美白保湿、促进伤口愈合等功能，在化妆品领域有巨大的应用前景。本文利用B16小鼠黑色素瘤细胞研究大鲵肽对酪氨酸酶活性的抑制作用和黑色素生成的影响；利用HaCaT人永生化角质形成细胞研究大鲵肽促进细胞迁移能力。以液晶乳化体系为载体，大鲵肽为活性成分制备大鲵肽复合液晶乳液，通过裸鼠肌肤机械屏障障碍模型评价其皮肤修复能力，并分析了其对人体皮肤的美白功效，对皮肤角质层含水量和经皮水分散失量的影响。结果表明，大鲵肽能够通过抑制酪氨酸酶活性并减少黑色素生成，且能一定程度上促进细胞迁移；大鲵肽复合液晶乳液能够促进小鼠肌肤屏障修复，促进表皮再生和愈合，并具有良好的美白、锁水保湿效果。大鲵肽展现了优秀的美白、保湿、促进皮肤修复能力，在化妆品领域有良好的应用前景。

关键词: 大鲵肽, 液晶乳液, 美白, 皮肤修复

Abstract:

The giant salamander peptides have the functions of anti-oxidation, anti-aging, whitening and moisturizing, and promoting wound healing, which have great application prospects in cosmetics. In this study, B16 mouse melanoma cells were used to study the effect of giant salamander peptides on tyrosinase activity and melanin content. Human keratinocyte （HaCaT） cells were used to study the effect of giant salamander peptides on cell repair ability. The liquid crystal emulsification system was used as the carrier, and the giant salamander peptides as the active ingredient to prepare the giant salamander peptides compound liquid crystal emulsion. The skin repair ability was evaluated by the skin mechanical barrier disturbance model in mice. Its effect on the water content of the skin stratum corneum and transepidermal water loss was also analyzed. The results show that giant salamander peptides are able to inhibit tyrosinase activity and reduce melanin production, and can promote cell repair to a certain extent. Moreover, the giant salamander peptides compound liquid crystal emulsion can promote the repair of the mouse skin barrier, and promote the regeneration and healing of the epidermis. It also has a good whitening, water-locking and moisturising effect. Overall, the giant salamander peptides have excellent whitening, moisturizing, and skin-repairing abilities, and have good application prospects in cosmetics.

Key words: giant salamander peptides, liquid crystal emulsion, whitening, skin repair

中图分类号:

TQ658

徐佳雯,郭婉黄,盛凯蔓,尚亚卓. 大鲵肽的护肤功效研究及其应用[J]. 日用化学工业（中英文）, 2025, 55(2): 194-201.

Jiawen Xu,Wanhuang Guo,Kaiman Sheng,Yazhuo Shang. Studies on the skin care efficacy and application of giant salamander peptides[J]. China Surfactant Detergent & Cosmetics, 2025, 55(2): 194-201.

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	使用前	使用4周后
L	71.5	74.3
a	-9 224.4	-9 648.0
b	52.5	52.4