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日用化学工业（中英文）

日用化学工业（中英文） ›› 2025, Vol. 55 ›› Issue (10): 1306-1312.doi: 10.3969/j.issn.2097-2806.2025.10.011

• 开发与应用 • 上一篇    下一篇

迷迭香活性成分异迷迭香酚的美白作用及抗氧化活性评价

郭庆宇1,*(),曹丹2,陈冬2   

  1. 1.江苏省徐州医药高等职业学校 制药工程系，江苏 徐州 221116
    2.江苏省徐州医药高等职业学校 药学技术系，江苏 徐州 221116
  • 收稿日期:2024-10-28 修回日期:2025-09-30 出版日期:2025-10-22 发布日期:2025-12-03
  • 通讯作者: 郭庆宇
  • 基金资助:
    徐州市科技局重点研发计划项目(KC23284)

Evaluation of the whitening effect and antioxidant activity of isorosmanol, an active ingredient of Rosmarinus officinalis L.

Qingyu Guo1,*(),Dan Cao2,Dong Chen2   

  1. 1. Department of Pharmaceutical Engineering, Jiangsu Provincia Xuzhou Pharmaceutical Vocational College, Xuzhou, Jiangsu 221116, China
    2. Department of Pharmacy, Jiangsu Provincial Xuzhou Pharmaceutical Vocational College, Xuzhou, Jiangsu 221116, China
  • Received:2024-10-28 Revised:2025-09-30 Online:2025-10-22 Published:2025-12-03
  • Contact: Qingyu Guo

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摘要：

本研究旨在评价迷迭香活性成分异迷迭香酚（isorosmanol）的美白作用及抗氧化活性。以紫外线B（UVB）诱导的皮肤光老化（SP）小鼠模型作为研究对象，对小鼠进行经皮应用3个剂量（1，2，4 mg/cm2）的异迷迭香酚。治疗8周后，与UVB组比较，L-isorosmanol组、M-isorosmanol组和H-isorosmanol组的表皮含水量升高表皮和真皮形态明显好转，MMP-1 mRNA水平降低，COL1A1 mRNA水平升高，黑色素含量、酪氨酸酶活性、TRP-1和TRP-2 mRNA相对水平降低，α-MSH和MC1R蛋白相对水平降低，SOD、CAT和GSH-Px活性升高，MDA含量降低，Nrf2（细胞核）蛋白相对水平升高，Keap1蛋白相对水平降低（P<0.05）。总之，在UVB诱导的SP小鼠中，异迷迭香酚通过抑制α-MSH/MC1R信号通路发挥美白作用，通过激活Nrf2/Keap1信号通路发挥抗氧化活性。

关键词: 异迷迭香酚, 皮肤光老化, 美白, 抗氧化, α-MSH/MC1R, Nrf2/Keap1

Abstract:

This study aimed to evaluate the whitening effect and antioxidant activity of isorosmanol, an active ingredient of Rosmarinus officinalis L.. The ultraviolet B （UVB）-induced skin photoaging （SP） mouse model was used as the research object, and then three doses （1, 2, and 4 mg/cm2） of isorosmanol were transdermally applied to the mice. After 8 weeks of treatment, compared with the UVB group, the epidermal water content in the L-isorosmanol group, the M-isorosmanol group, and the H-isorosmanol group increases the epidermal and dermal morphology improve significantly, the MMP-1 mRNA level decreases, the COL1A1 mRNA level increases, the melanin content, tyrosinase activity, TRP-1 and TRP-2 mRNA relative levels decrease, the α-MSH and MC1R protein relative levels decrease, the SOD, CAT, and GSH-Px activities increase, the MDA content decreases, the Nrf2 （nucleus） protein relative level increases, and the Keap1 protein relative level decreases （P<0.05）. In conclusion, in UVB-induced SP mice, isorosmanol exerts a whitening effect by inhibiting the α-MSH/MC1R signaling pathway and exerts antioxidant activity by activating the Nrf2/Keap1 signaling pathway.

Key words: isorosmanol, skin photoaging, whitening, antioxidant, α-MSH/MC1R, Nrf2/Keap1

中图分类号: 

  • TQ658