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日用化学工业(中英文) ›› 2025, Vol. 55 ›› Issue (6): 715-722.doi: 10.3969/j.issn.2097-2806.2025.06.005

• 开发与应用 • 上一篇    下一篇

经表皮失水率测量影响因素剖析及标准化操作研究

陈凤玲1,2,王亚茹1,2,叶蓉姿1,2,梁嘉恩1,2,谢嘉颖1,2,*(),谭建华1,2   

  1. 1.广州质量监督检测研究院,广东 广州 511447
    2.广州市NQI-质量安全科技协同创新中心,广东 广州 511447
  • 收稿日期:2024-06-07 修回日期:2025-05-13 出版日期:2025-06-22 发布日期:2025-07-01
  • 基金资助:
    广州市科技计划项目(2023B04J0407);广州市市场监督管理局科技项目(2022KJ03);广州市市场监督管理局知识产权助力关键技术科研攻关项目

Analysis of the influencing factors and study on the standardized operation of transepidermal water loss measurement

Fengling Chen1,2,Yaru Wang1,2,Rongzi Ye1,2,Jiaen Liang1,2,Jiaying Xie1,2,*(),Jianhua Tan1,2   

  1. 1. Guangzhou Quality Supervision and Testing Institute, Guangzhou, Guangdong 511447, China
    2. Collaborative Innovation Center for NQI-Quality Safety of Guangzhou, Guangzhou, Guangdong 511447, China
  • Received:2024-06-07 Revised:2025-05-13 Online:2025-06-22 Published:2025-07-01
  • Contact: E-mail: 47951945@qq.com.

摘要:

人体皮肤经表皮失水率(TEWL)的测试所受影响因素众多。通过设计不同的测试方案,对健康受试者的面颊及前臂内侧等区域的测试结果进行系统对比,探究测量方法、环境条件、受试部位及仪器设备等因素对TEWL测试结果的影响。结果表明,不同的测试方法(包括不同的测量模式、两次测量间隔时间、受试者等待时间和累积多次测量)均会影响测试结果的重现性,不同皮肤表面接触环境的温湿度、面部受试部位和昼夜时间等条件下的TEWL测试结果存在较大差异;不同型号的TEWL仪器之间测试结果具有强相关性,但测试稳定性具有显著差异。该研究较为系统地剖析了影响经表皮失水率测量的各种因素,建立了一个标准化的操作方法,为精准评价化妆品的功效提供可靠、科学的技术支撑。

关键词: 经表皮失水率, 影响因素, 功效评价, 标准化

Abstract:

The transepidermal water loss (TEWL) of human skin is affected by many factors. Different test schemes were designed to systematically compare the test results of the cheek and inner forearm and other areas of healthy subjects, and explore the influence of measurement methods, environmental conditions, test site, instruments and equipment on TEWL test results. The results show that different test methods (including different measurement modes, interval time between two measurement, subject waiting time and accumulated multiple measurements) affect the reproducibility of the test results, and TEWL test results are significantly different under different conditions of environment temperature and humidity that skin surface contact, facial test site and day and night time. There is a strong correlation between the test results of different types of TEWL instruments, but the test stability is significantly different. In this study, various factors affecting the measurement of transepidermal water loss are systematically analyzed, and a standardized operation method is established to provide reliable and scientific technical support for accurate evaluation of the efficacy of cosmetics.

Key words: transepidermal water loss, influencing factors, efficacy evaluation, standardization

中图分类号: 

  • TQ658