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日用化学工业（中英文）

日用化学工业（中英文） ›› 2024, Vol. 54 ›› Issue (9): 1099-1105.doi: 10.3969/j.issn.2097-2806.2024.09.011

• 开发与应用 • 上一篇    下一篇

酵母菌/锌发酵产物在头皮护理中的功效研究

尤孝鹏1,2,彭宁1,2,3,陈智仙1,2,3,*()   

  1. 1.农业微生物资源发掘与利用全国重点实验室，湖北 宜昌 443003
    2.酵母功能湖北省重点实验室，湖北 宜昌 443003
    3.宜昌市营养健康食品工程技术研究中心，湖北 宜昌 443003
  • 收稿日期:2023-10-11 修回日期:2024-08-26 出版日期:2024-09-22 发布日期:2024-09-26

Study on the efficacy of yeast/zinc fermentation products in scalp care

Xiaopeng You1,2,Ning Peng1,2,3,Zhixian Chen1,2,3,*()   

  1. 1. National Key Laboratory of Agricultural Microbiology, Yichang, Hubei 443003, China
    2. The Hubei Provincial Key Laboratory of Yeast Function, Yichang, Hubei 443003, China
    3. Yi Chang Engineering and Technology Research Center of Nutrition and Health Food, Yichang, Hubei 443003, China
  • Received:2023-10-11 Revised:2024-08-26 Online:2024-09-22 Published:2024-09-26
  • Contact: * E-mail: chenzxa@angelyeast.com.

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摘要：

从人体安全性、控油去屑功效、毛囊养护等方面初步认识酵母菌/锌发酵产物在头皮护理方面的功效。通过人体斑贴试验测试酵母菌/锌发酵产物的人体安全性；使用体外SZ95细胞模型研究酵母菌/锌发酵产物的控油功效，并使用qRT-PCR法验证油脂分泌相关基因SREBP-1c，PPARG和PI3K的表达；采用分光光度法测试酵母菌/锌发酵产物对5α-还原酶的抑制率；通过人体功效测试和离体毛囊模型分别研究酵母菌/锌发酵产物对头皮油脂的抑制效果和对毛囊的养护作用。结果表明：5%含量的酵母菌/锌发酵产物对人体安全隐患较小；0.8%~1.5%含量的酵母菌/锌发酵产物均可显著抑制5α-还原酶的活性；0.5%~2.0%含量的酵母菌/锌发酵产物均可显著抑制体外SZ95细胞油脂的分泌，并显著下调与油脂分泌相关基因SREBP-1c和PPARG的表达，1.0%、2.0%含量的酵母菌/锌发酵产物可显著抑制PI3K的表达；5%含量的酵母菌/锌发酵可显著降低头皮油脂分泌量，并具有改善毛囊周期和促进毛干增长的作用。因此，酵母菌/锌发酵产物具有一定头皮护理功效，在控油、改善毛囊健康、促进毛干生长等方面具有积极作用。

关键词: 酵母菌/锌发酵产物, 控油, 去屑, 功效评价

Abstract:

The efficacy of yeast/zinc fermentation products in scalp care were studied from the aspects of safety, oil control and dandruff removal, and hair follicle maintenance. The safety of yeast/zinc fermentation products was tested through human patch testing. In vitro SZ95 cell model was used to study the oil-control efficacy of yeast/zinc fermentation products. The method of qRT-PCR was used to verify the expression of oil-secretion-related genes SREBP-1c, PPARG, and PI3K. Spectrophotometry was used to test the effect of yeast/zinc fermentation products on 5α-reductase. The oil-control effect of yeast/zinc fermentation products on scalp and the maintenance effect on hair follicles were studied through human efficacy testing and in vitro hair follicle model, respectively. The results showed that the yeast/zinc fermentation products at a content of 5% was safe and harmless to human health; the yeast/zinc fermentation products with a content of 0.8%-1.5% could significantly inhibit the activity of 5α-reductase. The yeast/zinc fermentation products at a content of 0.5%-2.0% could significantly inhibit the secretion of oil in SZ95 cells in vitro, and significantly downregulate the expression of oil-secretion-related genes SREBP-1c and PPARG. The yeast/zinc fermentation products at content of 1.0% and 2.0% could significantly inhibit the expression of PI3K. The yeast/zinc fermentation products at a content of 5% could significantly reduce scalp oil secretion, improve hair follicle cycle, and promote hair shaft growth. Therefore, the yeast/zinc fermentation products had certain scalp care effects and had positive effects in controlling oil, improving hair follicle health, and promoting hair shaft growth.

Key words: yeast/zinc fermentation product, oil control, anti-dandruff, efficacy evaluation

中图分类号: 

  • TQ658