日用化学工业(中英文) ›› 2025, Vol. 55 ›› Issue (3): 367-380.doi: 10.3969/j.issn.2097-2806.2025.03.013
蓝云萍1,谢志洁2,赵楚杰3,刘晓纯1,王诗琼1,何秋星1,*()
收稿日期:
2024-11-10
修回日期:
2025-02-20
出版日期:
2025-03-22
发布日期:
2025-04-01
基金资助:
Yunping Lan1,Zhijie Xie2,Chujie Zhao3,Xiaochun Liu1,Shiqiong Wang1,Qiuxing He1,*()
Received:
2024-11-10
Revised:
2025-02-20
Online:
2025-03-22
Published:
2025-04-01
Contact:
*E-mail: 123090561@qq.com.
摘要:
利用合成生物学技术开发的化妆品原料,由于其既有效、安全又兼具环保性,正引起社会广泛关注。本文阐述了合成生物学的概念及其在化妆品原料生产中的主要技术和现状,并简要分析了不同国家和地区对合成生物学化妆品原料的监管情况,为我国相关领域管理提供指导,以保障产品安全,提升消费者认可,推动行业良性发展。
中图分类号:
蓝云萍, 谢志洁, 赵楚杰, 刘晓纯, 王诗琼, 何秋星. 国内外合成生物学化妆品原料的研究进展与监管[J]. 日用化学工业(中英文), 2025, 55(3): 367-380.
Yunping Lan, Zhijie Xie, Chujie Zhao, Xiaochun Liu, Shiqiong Wang, Qiuxing He. The research progress and regulation of cosmetic ingredients produced by synthetic biology at home and abroad[J]. China Surfactant Detergent & Cosmetics, 2025, 55(3): 367-380.
"
Production technology | Principle | Merit | Defect |
---|---|---|---|
Chemical synthesis technology | Compounds are synthesized by oxidation, reduction, alkylation, acylation and other chemical reactions | 1. High stability and strong functionality: The chemical synthesis production process of the anti-aging component Pro-xylane is relatively controllable, which can ensure the purity and quality stability of the product[ 2. Diversified and efficient production: Some commonly used preservatives, surfactants, etc., can achieve low-cost, high-efficiency and diversified production through chemical synthesis technology | 1. Pollute the environment: Some synthetic volatile organic compounds (VOCs) can cause air pollution. For example, during the production of nail polish, hair dye and phenylenediamine oxidative dyes[ 2. Have a relatively high safety risk: Cocamide DEA is used rather frequently in cosmetics. However, under certain conditions, it may form N-nitrosamine compounds, which pose certain safety risks[ |
Phytoextraction technique | The extraction of effective components from natural plants includes traditional technologies such as water extraction, alcohol extraction, organic solvent extraction, steam distillation and modern technologies such as supercritical CO2 extraction technology | 1. Natural, mild and multi-functional: Artemisia annua oil extracted from Artemisia annua has the effects of anti-inflammatory, soothing, regulating microecology and repairing skin barrier in skin care products[ 2. High efficiency and environmental protection: mild fermentation conditions, reduce energy consumption[ 3. Sustainability and environmental protection: The technology of plant extraction is relatively more sustainable | 1. Enrichment toxicity of chemical components: For example, Sophora flavescens is originally non-toxic, but after extraction, when alkaloids are enriched, it may become toxic. In addition, attention should also be paid to the transformation process of chemical components in the body. For instance, oxymatrine can be converted into matrine in the body[ 2. Risk of impurity residue introduction: Physical pressing extraction may have pesticide residues. There may be solvent residues in the extraction. Extraction with resin materials may introduce monomers, porogens or cross-linking agents[ 3. Resource and cost constraints: limited resources and complex extraction. For example, the extraction of paclitaxel from yew trees and the extraction of wild ginseng |
Bio-fermentation technology | Using enzyme engineering, microbial metabolic engineering and biochemical engineering, as well as cell growth characteristics and biocatalytic systems to react with organic substrates | 1. Enrich functional substances: The content of polysaccharides, flavonoids and peptides in Ganoderma lucidum fermentation broth is higher than that of Ganoderma lucidum aqueous extract[ 2. Reduce toxicity: Microbial fermentation of ginkgo leaves increased the content of active components such as flavonoids and lactones, while the toxic component ginkgolic acid was decomposed and transformed[ | 1. Complexity in product purification: In the fermentation process, it is necessary to purify and dispose of the harmful substances that may be produced, increasing the complexity and cost of the production process. For example, in the bio-fermentation expression of collagen, there are drawbacks such as the difficulty in resolubilizing inclusion bodies and incorrect folding[ 2. Strict production conditions: The fermentation system is extremely sensitive to the growth environment, such as temperature, nutrient concentration, pH, dissolved oxygen concentration and other factors[ |
Synthetic biology | Converging multiple disciplines, by writing DNA to guide organic reactions and constructing synthetic components with predictable and controllable properties | 1. Renewable and sustainable raw materials: Hyaluronic acid is produced by fermentation through synthetic biology technology to reduce the dependence on animal resource extraction. β-Farnesene is produced by fermenting sucrose with yeast engineering cells, and then high-purity squalene products are prepared by chemical reaction and purification[ 2. High product quality and purity: Tetrahydropyrimidine is developed by synthetic biology technology, and the purity of the product can reach over 98%[ 3. Directional design and diversification: Construction of recombinant collagen with different molecular weight. The production of hyaluronic acid with different molecular weights is achieved by modifying microbial chassis cells[ | 1. Technical sophistication: The exploration of metabolic pathways has always been a difficult point in synthetic biology, such as the synthesis of aromatic natural products and terpenoids. 2. Product safety verification and long-term monitoring: Some cosmetic raw materials produced by synthetic biotechnology on the market lack long-term human safety data. For example, although certain new bioactive substances have shown good effects in short-term laboratory tests and animal experiments, they may have potential adverse effects during long-term use by humans, such as allergic reactions and immune reactions. 3. Complex intellectual property rights and regulatory issues: The intellectual property system and standard system play a vital role in the process of technology research and development, product access and application development[ a balance between regulation and the innovation of synthetic biology remains a problem yet to be solved |
"
Component | Main efficacy | Synthetic biology pathway | Non-synthetic biological pathways |
---|---|---|---|
Hyaluronic acid (HA) | Moisturizing, skin repair, and anti-oxidation | By applying synthetic biology techniques, HA production can be enhanced through constructing heterologous HA synthesis pathways, strengthening precursor synthesis gene expression, reducing carbon flux in competitive metabolic branches, modifying HA synthase, and optimizing fermentation conditions[ | HAS catalyzes the polymerization of HA chains using Mg2+ and two precursor substrates, GlcA-UDP and GlcNAc-UDP[ |
Collagen | Moisturizing, promoting skin repair and regeneration, maintaining skin elasticity | By applying synthetic biology techniques, recombinant collagen production is achieved through constructing engineered cell banks, building expression systems, precisely controlling fermentation, and purifying cell expression systems[ | Mainly through animal and plant extraction |
Niacinamide | Whitening, anti-acne, anti-aging, and anti-inflammatory | By modifying redox enzyme coenzyme preferences for NAD and NADP, target compound yields can be increased; engineering yeast cell surfaces to alter nicotinamide riboside kinase enables whole-cell catalysis of β-nicotinamide mononucleotide production[ | This can be prepared by dehydrating the salt formed from niacin and ammonia. Additionally, it can be extracted from natural biomaterials that contain niacinamide or its precursors |
Astaxanthin | Antioxidant, anti-inflammatory, moisturizing, whitening, and anti-wrinkle | By establishing CRISPR/Cas9 technology, genes involved in the biosynthetic pathway of astaxanthin have been integrated into three chromosomal loci of Pichia pastoris, thereby creating a cell factory for astaxanthin production[ | Haematococcus pluvialis and Chlorella zofingiensis are key strains for astaxanthin production Haematococcus pluvialis and Chlorella zofingiensis are key strains for astaxanthin production[ |
Ergothioneine (ERG) | Antioxidant, whitening, and anti-aging | By modifying the key enzymes Nc Egt1 and Egt D in an ergothionein-producing strain, the yield of ergothionein is improved[ | Extraction methods include biological extraction (using raw materials like fruiting bodies of edible fungi, plant seeds, and animal tissues), chemical synthesis, and biosynthesis (through microbial liquid fermentation and bioconversion)[ |
Ceramide | Moisturizing, skin repair, anti-inflammatory, and anti-aging | By strengthening precursor pathways (e.g., regulating palmitoyl-CoA and L-serine levels), weakening competitive pathways (e.g., knocking out kinases), and relieving feedback inhibition (e.g., deleting ORM1 and ORM2 genes), ceramide production can be enhanced[ | Among the plant sources for natural extraction are konjac, rice bran, potatoes and so on. Ceramide is extracted by yeast fermentation. Chemical synthesis: using 2, 4-O-benzylidene-D-threose as the starting material, ceramide is synthesized through a series of chemical reactions[ |
Sialic acid | Moisturizing, and antioxidant | By utilizing whole cells, Neu5Ac can be produced from GlcNAc and pyruvate or directly from unrelated carbon sources via microbial fermentation[ | Extraction can be performed from plants, animals, and microorganisms |
Squalane | Sebum regulation, and antioxidation | By enhancing precursor supply, knocking out competitive pathways, modifying enzymes, expressing heterologous genes, regulating central carbon metabolism, enabling coenzyme regeneration, and utilizing promoter engineering, squalene production can be increased[ | Extract from shark liver |
Arbutin | Melanogenesis inhibition, antibacterial and anti-inflammatory activity | By introducing 4-hydroxybenzoic acid hydroxylase from Candida parapsilosis CBS604 into Escherichia coli, catechol production is catalyzed[ | β-Arbutin can be extracted from sources such as bearberry leaves, pears, wheat, coffee, and tea. Additionally, plant cell culture techniques can be used to convert exogenous catechol into β-arbutin |
Succinic acid | pH regulator, anti-oxidation, and promoting blood circulation | By expressing malate dehydrogenase derived from Corynebacterium glutamicum in Mannheimia succiniciproducens, the production of malate can be enhanced[ | Initially, succinic acid is extracted from natural amber, and later, it began to be produced through chemical synthesis and biological fermentation |
γ-polyglutamic acid | Tyrosinase activity inhibition, and melanin production reduction | By applying CRISPR-Cas9n technology to modify Bacillus amyloliquefaciens, the yield of γ-polyglutamic acid is enhanced[ | It is primarily found in microorganisms such as Bacillus anthracis, Bacillus licheniformis, and Bacillus subtilis |
Malic acid | pH regulator | By modifying metabolic pathways and applying genetic engineering in Aspergillus niger, citric acid accumulation is reduced, with enhanced glycolysis flux, and increased malic acid yield; in Escherichia coli, overexpressing PEPC and MDH redirects metabolic flux toward L-malic acid synthesis[ | Malic acid can be produced using various microorganisms, including Aspergillus, Escherichia coli, Saccharomyces cerevisiae, and Pichia pastoris |
"
Country / Region | Supervisory body | Supervision laws | Regulatory focus | Supervision characteristics | Reference |
---|---|---|---|---|---|
USA | Food and Drug Administration (FDA) | Federal Food, Drug, and Cosmetic Act (FDCA) | Safety, and innovation encouragement | State-level supervision is the main way. FDA guarantees overall safety and encourages innovation | [ |
EU | European Commission (EU), Scientific Committee on Consumer Safety (SCCS) | EU Cosmetics Regulation (EC) 1223 / 2009 | Safety, and risk assessment | Negative List Management (Disabled and Restricted Substances List), and SCCS Safety Assessment | [ |
Japan | Ministry of Health Labor | Cosmetics safety standards and other relevant provisions | Safety, and compliance | Negative list system, and industry independent standard auxiliary management | [ |
Korea | Ministry of Food and Drug Safety (MFDS) | Cosmetics Law and its implementation order, implementation rules, etc. | Safety, and functional review | Prohibited component management, functional cosmetics review, and focus on safety supervision | [ |
China | State Food and Drug Administration (NMPA) | Cosmetics supervision and management regulations, etc. | Safety, and effectiveness | Classified management, new raw materials need to register or record, strict technical review and safety assessment | [ |
[1] | Huang Dongting, Meng Fei, Liang Lei, et al. Synthesis of pro-xylane[J]. Guangdong Chemical Industry, 2018, 45 (10): 73-74. |
[2] | Chen Panjin. Research on release characteristics,environmental impact and the human healthy risk of VOCs in consumer products[D]. Beijing: Beijing University of Chemical Technology, 2023. |
[3] | Chen Zhanghao, Zhou Zhiming, Xiao Shuxiong, et al. Safety risk of N-nitroamines in cosmetics[J]. China Food & Drug Administration Magazine, 2022, 25 (1): 50-56. |
[4] | Wang Xiangzhe, Zheng Zhao, Liu Yang, et al. Research progress on constituents, biological activity, and application of Artemisia Annua volatile oil[J]. Northwest Pharmaceutical Journal, 2024, 39 (6): 247-257. |
[5] | Cang Haibo. Application of fermentation engineering technology in food development[J]. Modern Food, 2018, 4 (11): 53-55. |
[6] | Zhang Mingfa, Shen Yaqin. Research progress on toxicity of matrine-type alkaloids[J]. Drug Evaluation Research, 2018, 41 (4): 682-691. |
[7] | Li Yajie. Risk assessment on plant extracts in cosmetic products[J]. Chemical Engineering Management, 2022, 37 (13): 36-38, 46. |
[8] | Zhao Dan, Xu Danni, Wang Dongdong, et al. Analysis of fermentation liquor of Ganoderma lucidum and evaluation of its whitening and anti-senility efficacy[J]. China Surfactant Detergent & Cosmetics, 2016, 46 (4): 226-230, 242. |
[9] | Ren Jinmei. Study on the effects of removing Ginkgo Biloba acid by fermentation[D]. Xi'an: Shaanxi University of Science & Technology, 2015. |
[10] | Fertala A. Three decades of research on recombinant collagens: Reinventing the wheel or developing new biomedical products?[J]. Bioengineering, 2020 (4). |
[11] | Li Yang, Huang Dan, Yang Anquan, et al. Biological fermentation of plant extracts and their products in cosmetics[J]. Journal of Forestry Engineering, 2024, 9 (5): 1-12. |
[12] | Xu Wen, Ma Xi, Wang Yang, et al. Production of squalene by microbes: an update[J]. World Journal of Microbiology, 2016, 32 (12): 195. |
[13] | Xue Binjuan, Han Rui, Qiao Lijuan, et al. Mutation sites and high ectoine production mechanism of a Halomonas mutant induced by ultraviolet radiation[J]. Acta Microbiologica Sinica, 2024, 64 (12): 4902-4917. |
[14] | Hu Yunxiao. Optimization of hyaluronic acid synthesis in Streptococcus zooepidemicus based on omics analysis[D]. Wuxi: Jiangnan University, 2023. |
[15] |
Chen Daming, Zhou Guangming, Liu Xiao, et al. Analysis of global patents for the trend of synthetic biology inventions[J]. Synthetic Biology Journal, 2020, 1 (3): 372-384.
doi: 10.12211/2096-8280.2020-035 |
[16] | Guo Xueping. Synthetic biology: the innovative driving force for cosmetic ingredients[J]. China Cosmetics Review, 2021 (12): 18-24. |
[17] | Benner S A, Sismour A M. Synthetic biology[J]. Nature Reviews Genetics, 2005, 6 (6): 533-543. |
[18] | Qiu Yibin, Zhu Yifan, Sha Yuanyuan, et al. Development of a robust bacillus amyloliquefaciens cell factory for efficient poly(γ-glutamic acid) production from jerusalem artichoke[J]. ACS Sustainable Chemistry & Engineering, 2020, 8 (26): 9763-9774. |
[19] |
Xu Yongxue, Zhou Yutao, Cao Wei, et al. Improved production of malic acid in aspergillus niger by abolishing citric acid accumulation and enhancing glycolytic flux[J]. ACS Synthetic Biology, 2020, 9 (6): 1418-1425.
doi: 10.1021/acssynbio.0c00096 pmid: 32379964 |
[20] | Yan Wei, Gao Hao, Jiang Wankui, et al. The de novo synthesis of 2-phenylethanol from glucose by the synthetic microbial consortium composed of engineered Escherichia coli and Meyerozyma guilliermondii[J]. 2022, 11 (12): 4018-4030. |
[21] | Xiao Sen, Hu Litao, Shi Zhicheng, et al. Research advances in biosynthesis of hyaluronic acid with controllable molecular weights[J]. Synthetic Biology Journal, 2024: 1-16. |
[22] | Weigel P H. Hyaluronan synthase: the mechanism of initiation at the reducing end and a pendulum model for polysaccharide translocation to the cell exterior[J]. International Journal of Cell Biology, 2015 (1): 367579. |
[23] | Guo Xiaolei, Ma Yuan, Wang Hang, et al. Status and developmental trends in recombinant collagen preparation technology[J]. Regenerative Biomaterials, 2024, 11: rbad106. |
[24] | You Chun, Huang Rui, Wei Xinlei, et al. Protein engineering of oxidoreductases utilizing nicotinamide-based coenzymes, with applications in synthetic biology[J]. Synthetic & Systems Biotechnology, 2017, 2 (3): 208-218. |
[25] |
He Zhonghui, Yang Xiaosong, Tian Xin, et al. Yeast cell surface engineering of a nicotinamide riboside kinase for the production of β-nicotinamide mononucleotide via whole-cell catalysis[J]. ACS Synthetic Biology, 2022, 11 (10): 3451-3459.
doi: 10.1021/acssynbio.2c00350 pmid: 36219824 |
[26] | Gao Jucan, Xu Junhao, Zuo Yimeng, et al. Synthetic biology toolkit for marker-less integration of multigene pathways into Pichia pastoris via CRISPR/Cas9[J]. ACS Synthetic Biology, 2022, 11 (2): 623-633. |
[27] | Patel A K, Tambat V S, Chen Chiuwen, et al. Recent advancements in astaxanthin production from microalgae: A review[J]. Bioresour Technol, 2022, 364: 128030. |
[28] | Zhang Luwen, Tang Jiawei, Feng Meiqing, et al. Engineering methyltransferase and sulfoxide synthase for high-yield production of ergothioneine[J]. Journal of Agricultural and Food Chemistry, 2022, 71 (1): 671-679. |
[29] | Li Liang, Xu Shanshan, Jiang Yanjun. Research progress in the production of ergothioneine by biosynthesis[J]. Biotechnology Bulletin, 2024, 40 (1): 86. |
[30] | Lu Jinchang, Wu Yaokang, Lv Xueqin, et al. Green biomanufacturing of ceramide sphingolipids[J]. Synthetic Biology Journal, 2024. |
[31] | Wild R, Schmidt R R. Sphingosine and phytosphingosine from D-threose synthesis of a 4-keto-ceramide[J]. Tetrahedron: Asymmetry, 1994, 5 (11): 2195-2208. |
[32] | Yang Haiquan, Lu Liping, Chen Xianzhong. An overview and future prospects of sialic acids[J]. Biotechnology Advances, 2021, 46: 107678. |
[33] | Paramasivan K, Mutturi S. Recent advances in the microbial production of squalene[J]. World Journal of Microbiology and Biotechnology, 2022, 38 (5): 91. |
[34] |
Shen Xiaolin, Wang Jia, Wang Jian, et al. High-level De novo biosynthesis of arbutin in engineered Escherichia coli[J]. Metabolic Engineering, 2017, 42: 52-58.
doi: S1096-7176(17)30093-9 pmid: 28583673 |
[35] | Ahn J H, Seo H, Park W, et al. Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase[J]. Nature Communications, 2020, 11 (1): 1970. |
[36] |
Wu Na, Zhang Jiahui, Chen Yaru, et al. Recent advances in microbial production of L-malic acid[J]. Applied Microbiology and Biotechnology, 2022, 106 (24): 7973-7992.
doi: 10.1007/s00253-022-12260-y pmid: 36370160 |
[37] | Zhi Guangyuan, Zhang Lu. Ethical issues and their dissolution of human gene editing technology[J]. Chinese Medical Ethics, 2024, 37 (10): 1139-1145. |
[38] | He Miao, Su Zhe, Hu Kang, et al. Discussion of cosmetic ingredient management and regulatory system of cosmetic ingredient safety information submission[J]. China Surfactant Detergent & Cosmetics, 2023, 53 (9): 1080-1086. |
[39] | Hu Fanghua, Yu Qionghua, Yuan Hai, et al. Analysis on the risk factors of cosmetics safety[J]. Flavour Fragrance Cosmetics, 2017 (3): 64-68. |
[40] | Joshi M, Hiremath P, John J, et al. Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases[J]. Pharmacol, 2023, 75 (5): 1096-1114. |
[41] | Tang Chuagen, Wang Jing, Zhang Shuo, et al. Recent advances in synthesis and mining strategies of functional peptides[J]. Synthetic Biology Journal, 2024: 1-18. |
[42] | Zhu Ming, Xu Runda, Yuan Junsong, et al. Tracking-seq reveals the heterogeneity of off-target effects in CRISPR-Cas9-mediated genome editing[J]. Nature Biotechnology, 2024. |
[43] | Guru R K S, Ganpatrao A S, Madhao A P, et al. Biosafety and biosecurity concerns associated with plant genome editing[M]. Genome Editing and Global Food Security. Routledge, 2024: 236-274. |
[44] | Ma Lili, Ou Yakun, Ren Yijia, et al. Study on biosafety risks of synthetic biology and its management strategies[J]. Science and Society, 2022, 12 (3): 15-32. |
[45] | Wu Jiaojiao, Zhang Wei, Wang Yanchao, et al. Safety evaluation progress of three kinds of arbutin and its current status in cosmetics regulations[J]. China Surfactant Detergent & Cosmetics, 2024, 54 (7): 853-858. |
[46] | Lv Qinglan. Metabolic engineering of Corynebacterium glutamicum for efficient biosynthesis of L-glutamine[D]. Wuxi: Jiangnan University, 2022. |
[47] | Alani J I, Davis M D P, Yiannias J A. Allergy to cosmetics: a literature review[J]. Dermatitis Contact Atopic Occupational & Drug, 2013, 24 (6): 283-290. |
[48] |
Zeng Xiaomei, Jiang Hailun, Yang Guangying, et al. Regulation and management of the biosecurity for synthetic biology[J]. Synthetic and Systems Biotechnology, 2022, 7 (2): 784-790.
doi: 10.1016/j.synbio.2022.03.005 pmid: 35387231 |
[49] | Ferreira M T, Matos A S, Couras A, et al. Overview of cosmetic regulatory frameworks around the world[J]. Cosmetics, 2022, 9 (4): 72. |
[50] |
Katz L M, Lewis K M, Spence S L, et al. Regulation of cosmetics in the United States[J]. Dermatol. Clin., 2022, 40 (3): 307-318.
doi: 10.1016/j.det.2022.02.006 pmid: 35750414 |
[51] | Ding Ning, Lu Ping. Application of CRISPR/Cas9 genome editing technology in filamentous fungi[J]. Journal of Green Science and Technology, 2024, 26 (8):255-264. |
[52] | Lintner K. Global regulatory issues for the cosmetics industry[M]. Boston: William Andrew Publishing, 2009: 31-53. |
[53] | Peters D, Choi J. Status of cosmetics regulations in Korea[J]. International Chemical Regulatory and Law Review, 2020, 3 (2): 73-80. |
[54] | Su Zhe, Luo Feiya, Pei Xinrong, et al. Final publication of the “Regulations on the Supervision and Administration of Cosmetics” and new prospectives of cosmetic science in China[J]. Cosmetics, 2020, 7 (4): 98. |
[55] | Xu Yuyuan, Tian Deqiao. Overview and analysis of biotechnology security governance in the United States[J]. World Sci-Tech R & D, 2024, 46 (2):182-196. |
[56] | Legislature California State. California State: 2020 Toxic-Free Cosmetics Act[Z]. 2020. |
[57] | Brandon S, Jacob J, Stephen J D. The collaborative structure of synthetic biology ethics[J]. Proceedings of the Association for Information Science and Technology, 2020, 57 (1): 57. |
[58] | Union European Parliament. Council of the European. Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products (recast) (Text with EEA relevance)[Z]. 2024. |
[59] | Commission European. Commission Regulation (EU) 2024/996 of 3 April 2024 amending Regulation (EC) No 1223/2009 of the European Parliament and of the Council as regards the use of Vitamin A, Alpha-Arbutin and Arbutin and certain substances with potential endocrine disrupting properties in cosmetic products[Z]. 2024. |
[60] | Mori Y, Yoshizawa G. Current situation of synthetic biology in Japan[J]. Journal of Disaster Research, 2011, 6 (5): 476-481. |
[61] |
Nohynek G J, Antignac E, Re T, et al. Safety assessment of personal care products/cosmetics and their ingredients[J]. Toxicology and Applied Pharmacology, 2010, 243 (2): 239-259.
doi: 10.1016/j.taap.2009.12.001 pmid: 20005888 |
[62] | Salvador A, Chisvert A. Analysis of cosmetic products (Second Edition)[M]. Boston: Elsevier, 2018: 3-37. |
[63] |
Inomata S. Safety assurance of cosmetics in Japan: current situation and future prospects[J]. Journal of Oleo Science, 2014, 63 (1): 1-6.
pmid: 24389794 |
[64] | Huang Xianglu, Su Zhe, Liu Min, et al. Progress in the revision of cosmetic regulations in other countries and regions and its enlightenments to China[J]. Flavour Fragrance Cosmetics, 2021, 49 (1): 89-94. |
[65] | Ou Yakun, Lei Ruipeng, Ji Peng. Preliminary exploration of safety and ethical issues in synthetic biology and their countermeasures[J]. Biotechnology & Business, 2019, 13 (1): 91-94. |
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