关键词: 硝基甲烷, 风险评估, 化妆品原料, 监管

Abstract:

Nitromethane has been classified by the International Agency for Research on Cancer （IARC, 2000） as a Group 2B carcinogen. There is sufficient evidence in experimental animals for the carcinogenicity of nitromethane. Relevant institutions and organizations have evaluated its safety and restricted its use all over the world. In the European Union and Malaysia, nitromethane is allowed in cosmetic products at a maximum concentration of 0.3%, and South Korea bans the use of nitromethane in cosmetics. In addition, China, United States and Japan all regulate the residue limit of nitromethane in drugs. Our key laboratory assessed the safety of its use in cosmetics, and aimed to provide advice and suggestion for cosmetics supervision. Via dermal absorption and inhalation are the main routes of exposure to nitromethane from products. Based on the current toxicological research data, we conducted the risk assessment of nitromethane in various cosmetic products such as mascara, eyeliner, body lotion and hair spray, and made comparative analysis of use regulations in various countries. The results show that the MoE value of nitromethane is less than 1 when the limit of it in cosmetics is 0.3%（w/w）, so the carcinogenic risk of nitromethane should be concerned. Due to no cosmetics sold in China have been identified containing nitromethane at present, and individual cosmetic products containing nitromethane overseas are not added as cosmetic raw materials. It is recommended to include nitromethane in the list of prohibited substances in cosmetics.

Key words: nitromethane, risk assessment, cosmetics materials, use regulation