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日用化学工业（中英文）

日用化学工业 ›› 2018, Vol. 48 ›› Issue (2): 88-93.doi: 10.13218/j.cnki.csdc.2018.02.006

• 开发与应用 • 上一篇    下一篇

马齿苋的多功效研究及安全性评价

刘晓敏1,2, 龙春霞1,2   

  1. 1.广东药科大学 医药化工学院,广东 中山 528458;
    2.广东省化妆品工程技术研究中心,广东 中山 528458
  • 收稿日期:2017-10-16 发布日期:2019-03-21
  • 通讯作者: 龙春霞,副教授,硕士生导师,博士,电话:13512715015,E-mail:cx-long@163.com。
  • 作者简介:刘晓敏(1992-),女,广东江门人,硕士研究生,电话:13428281988,E-mail:chemlxm@163.com。
  • 基金资助:
    广东省化妆品工程技术研究中心开放项目

Study on functions of purslane and evaluation of its safety

LIU Xiao-min1,2, LONG Chun-xia1,2   

  1. 1.School of Chemistry and Chemical Engineering,Guangdong Pharmaceutical University,Zhongshan,Guangdong 528458,China;
    2.Guangdong Cosmetics Engineering & Technology Research Center,Zhongshan,Guangdong 528458,China
  • Received:2017-10-16 Published:2019-03-21

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摘要： 以马齿苋作为研究对象,通过多种方法对其抑菌、美白、抗衰老、抗炎、抗敏等功效进行研究并对其安全性进行评价。结果显示,当马齿苋提取液质量浓度为125 g/L时,对5种常见菌均有抑制效果;质量浓度为2.0 g/L时,对酪氨酸酶的抑制率为82.49%,对DPPH自由基的清除率达100%,对羟自由基的清除率为92.56%,均高于同质量浓度的VC;质量浓度为150 g/L时,对小鼠耳廓肿胀抑制率为55.74%;质量浓度为1.5 g/L时,对透明质酸酶的体外抑制率为72.37%;质量浓度为200 g/L时,RBC溶血率为45.78%,半数溶血量为230 g/L;质量浓度不超过150 g/L的家兔急性眼刺激和人体安全性评价等级为安全无刺激。马齿苋具有较好的抑菌、美白、抗衰老、抗炎、抗敏功效,是一种安全无刺激的化妆品原料。

关键词: 化妆品原料, 马齿苋, 多功效, 安全性

Abstract: Taking purslane as the research object,the study on its functions such as bacteriostatic,whitening,anti-aging,anti-inflammation and anti-allergy,and evaluation of its safety were carried out through a variety of methods.Results show that when the mass concentration of purslane extract is 125 g/L,it can inhibit five kinds of common bacteria.When the mass concentration is 2.0 g/L,the inhibition rate of tyrosinase is 82.49%,the scavenging rate of DPPH radical is 100%,and the scavenging rate of hydroxyl radical is 92.56%,all higher than the same mass concentration of vitamin C.When the mass concentration is 150 g/L,the mice auricle swelling inhibition rate is 55.74%.When the mass concentration is 1.5 g/L,the inhibition rate of hyaluronidase in vitro is 72.37%.When the mass concentration is 200 g/L,the RBC hemolytic ratio is 45.78%,and the half hemolytic dose is 230 g/L.Results of acute eye irritation test of rabbits and human safety rating are safe and non-irritating,when the mass concentration is not exceeded 150 g/L.Purslane has good bacteriostatic,whitening,anti-aging,anti-inflammatory,and anti-allergic functions,is a safe and non-irritating cosmetics raw materials.

Key words: raw material of cosmetics, purslane, functions, safety

中图分类号: 

  • TQ658