高稳定二溴海因水溶液制备及其消毒效果研究

doi:10.3969/j.issn.1001-1803.2019.01.009

日用化学工业 ›› 2019, Vol. 49 ›› Issue (1): 40-43.doi: 10.3969/j.issn.1001-1803.2019.01.009

高稳定二溴海因水溶液制备及其消毒效果研究

周龙梅¹,张亮亮²,王金燕²

1.山东利尔康医疗科技股份有限公司上海研发中心,上海 201203
2.山东利尔康医疗科技股份有限公司,山东德州 253032

收稿日期:2018-06-07 修回日期:2018-12-05 出版日期:2019-01-20 发布日期:2019-03-06
作者简介:周龙梅（1977-）,女,江苏人,工程师,电话：（021）61060198,E-mail： zlmandhlq@hotmail.com。

Preparation and disinfection effect of a highly stable aqueous solution of dibromohydantoin （DBDMH）

ZHOU Long-mei¹,ZHANG Liang-liang²,WANG Jin-yan²

1.Shanghai Research and Development Center of Shandong Lircon Medical Technology Co., Ltd., Shanghai 201203, China
2.Shandong Lircon Medical Technology Co., Ltd., Dezhou, Shandong 253032, China

Received:2018-06-07 Revised:2018-12-05 Online:2019-01-20 Published:2019-03-06

摘要/Abstract

摘要：

以氨基磺酸为稳定剂,配制质量浓度为25. 3 g/L的二溴海因水溶液,测定了水溶液的紫外吸收光谱、稳定性和杀菌性。由实验结果可知,该水溶液在波长280 nm处有吸收峰,表明水溶液中氨基磺酸氮原子与二溴海因分子中的部分活性溴形成共价键,从而减缓活性溴的释放,增强二溴海因在水溶液中的稳定性;稳定性实验表明该水溶液具有良好的稳定性;二溴海因质量浓度为1 000 mg/L的消毒液对悬液中大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌具有优异的杀菌效果,二溴海因质量浓度为2 500 mg/L的消毒液对悬液中白色念珠菌具有优异的杀菌效果;现场消毒实验表明二溴海因消毒液对物体表面自然菌具有良好的杀菌效果。

关键词: 二溴海因, 氨基磺酸, 消毒剂, 消毒效果

Abstract:

An aqueous solution of dibromohydantoin （DBDMH） whose concentration was 25.3 g/L was prepared with sulfamic acid as the stabilizer. The UV absorption spectrum, stability and bactericidal activity of this solution were examined. The experimental results show that, there is an absorption peak at the wavelength of 280 nm, indicating that covalent bonds have been formed between the nitrogen atoms in the sulfamic acid molecules and part of active bromine atoms in the DBDMH molecules. This can reduce the release of the active bromines and help to stabilize the DBDMH in the water. The results of stability test reveal that the solution is very stable. It is found that the solution containing 1 000 mg/L DBDMH shows superior disinfection effects against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The solution containing 2 500 mg/L DBDMH shows superior disinfection effects against Candida albicans in the suspension. The results of the spot test show that the solution of DBDMH also shows good disinfection effects against natural germs.

Key words: DBDMH, sulfamic acid, disinfector, disinfection effect

中图分类号:

R187

周龙梅,张亮亮,王金燕. 高稳定二溴海因水溶液制备及其消毒效果研究[J]. 日用化学工业, 2019, 49(1): 40-43.

Long-mei ZHOU,Liang-liang ZHANG,Jin-yan WANG. Preparation and disinfection effect of a highly stable aqueous solution of dibromohydantoin （DBDMH）[J]. China Surfactant Detergent & Cosmetics, 2019, 49(1): 40-43.

图/表 3

图 1

表 1

表 2

参考文献 9

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序号	试验菌	ρ（二溴海因）/（mg·L^-1）	实验菌浓度/（CFU·mL^-1）	不同作用时间杀灭对数值
序号	试验菌	ρ（二溴海因）/（mg·L^-1）	实验菌浓度/（CFU·mL^-1）	10 min 15 min 20 min
1	大肠杆菌	1 000	4.40×10⁷	5.62 6.23 6.64
	金黄色葡萄球菌		2.23×10⁷	5.39 5.74 6.34
	铜绿假单胞菌		4.20×10⁷	6.10 6.62 6.62
	白色念珠菌	2 500	2.75×10⁶	5.12 5.50 5.80
2	大肠杆菌	500	4.60×10⁷	5.21 5.62 5.96
	金黄色葡萄球菌		2.40×10⁷	5.13 5.30 5.48
	铜绿假单胞菌		2.90×10⁷	4.21 4.56 4.87
	白色念珠菌	1 000	1.45×10⁶	2.91 3.35 3.82
3	大肠杆菌	1 000	5.70×10⁷	5.30 5.75 6.31
	金黄色葡萄球菌		2.85×10⁷	5.14 5.52 6.13
	铜绿假单胞菌		3.22×10⁷	5.36 5.82 6.46
	白色念珠菌	2 500	1.75×10⁶	4.54 4.85 5.23

编号	菌数/CFU		杀灭对数值	编号	菌数/CFU		杀灭对数值
编号	阳性对照组	实验组	杀灭对数值	编号	阳性对照组	实验组	杀灭对数值
1	60	10	0.78	16	3 690	100	1.567
2	300	90	0.52	17	5 560	120	1.666
3	2 350	350	0.83	18	1 150	310	0.569
4	3 000	260	1.06	19	4 280	180	1.376
5	1 390	430	0.51	20	3 050	290	1.021
6	32 000	230	2.14	21	5 130	215	1.38
7	2 190	120	1.26	22	4 100	241	1.23
8	40 000	230	2.24	23	1 520	180	0.925
9	2 370	160	1.17	24	2 670	270	1.00
10	2 000	350	0.76	25	1 890	170	1.046
11	14 000	170	1.915	26	11 200	330	1.53
12	760	260	0.465	27	17 800	420	1.63
13	2 450	140	1.243	28	4 500	400	1.053
14	3 970	210	1.276	29	3 900	120	1.511
15	8 500	1 140	0.872	30	4 850	340	1.155
杀灭对数平均值		1.19

高稳定二溴海因水溶液制备及其消毒效果研究

Preparation and disinfection effect of a highly stable aqueous solution of dibromohydantoin （DBDMH）

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