头皮屑发生机理及头皮生物化学变化研究进展

doi:10.13218/j.cnki.csdc.2017.12.012

摘要/Abstract

摘要： 综述了头皮脂膜与微生态、头皮屏障功能以及头皮生物化学变化等研究成果,总结出头皮屑人群与健康人群在头皮微生态、头皮皮脂分泌、皮脂组分及屏障相关蛋白质和脂质等方面的差异。推断皮脂分泌、屏障受损、微生态失衡这三种主要因素之间可能的相互作用关系,为更加科学有效的去屑洗发剂的研发提供新思路。

关键词: 头皮屑, 头皮微生态, 头皮屏障, 去屑洗发剂

Abstract: Research work achievements with respect to scalp lipid membrane and its microecology,scalp barrier function as well as biochemical changes of the scalp were reviewed.Differences between scalp of conventional persons and persons with abnormal dandruff in view of the changes of the scalp microecology,scalp sebum secretion,sebum components and the occurrence of the proteins and lipids related to the barrier were summarized.A comprehensive description of the mechanism of dandruff formation,and the possible interactions among the three major factors of sebum secretion,barrier damage and micro-ecological imbalance were provided,and it might infer a new idea for the development of more scientific and effective research work for preparation of anti-dandruff shampoo.

Key words: dandruff, scalp microecology, scalp barrier, anti-dandruff shampoo

中图分类号:

TQ658.3

韦诗雨, 杜一杰, 李丽, 马来记, 董银卯. 头皮屑发生机理及头皮生物化学变化研究进展[J]. 日用化学工业, 2017, 47(12): 713-718.

WEI Shi-yu, DU Yi-jie, LI Li, MA Lai-ji, DONG Yin-mao. Progress in research work field with respect to the mechanism of dandruff and biochemical changes of dandruff scalp[J]. China Surfactant Detergent & Cosmetics, 2017, 47(12): 713-718.

参考文献

[1] Turner G A,Hoptroff M,Harding C R.Stratum corneum dysfunction in dandruff [J].International Journal of Cosmetic Science,2012,34(4):298.
[2] Sheth R A,Desai S C.Dandruff:assessment and management [J].International Journal of Dermatology,1983,22(9):511-514.
[3] Schwartz J R,Messenger A G,Tosti A,et al.A comprehensive pathophysiology of dandruff and seborrheic dermatitis - towards a more precise definition of scalp health [J].Acta Dermato-Venereologica,2013,93(2):131.
[4] 刘小萍,王学民.微生态和皮肤屏障与头皮屑[J].国际皮肤性病学杂志,2014,40(2):106-109.
[5] Harding C R,Moore A E,Rogers J S,et al.Dandruff:a condition characterized by decreased levels of intercellular lipids in scalp stratum corneum and impaired barrier function [J].Archives of Dermatological Research,2002,294(5):221-230.
[6] Misery L,Rahhali N,Duhamel A,et al.Epidemiology of dandruff,scalp pruritus and associated symptoms [J].Acta Dermato-Venereologica,2012,93(1):80.
[7] Borda L J,Wikramanayake T C.Seborrheic dermatitis and dandruff:a comprehensive review [J].Journal of Clinical & Investigative Dermatology,2015,3(2):1-22.
[8] Gaitanis G,Magiatis P,Hantschke M,et al.The Malassezia genus in skin and systemic diseases [J].Clinical Microbiology Reviews,2012,25(1):106-141.
[9] Soares R C,Camargopenna P H,de Moraes V C,et al.Dysbiotic bacterial and fungal communities not restricted to clinically affected skin sites in dandruff [J].Frontiers in Cellular & Infection Microbiology,2016(6):157.
[10] Clavaud C,Jourdain R,Barhen A,et al.Correction:Dandruff is asso-ciated with disequilibrium in the proportion of the major bacterial and fungal populations colonizing the scalp [J].Plos One,2013,8(3):58203.
[11] Park M,Cho Y J,Lee Y W,et al.Whole genome sequencing analysis of the cutaneous pathogenic yeast Malassezia restricta and identification of the major lipase expressed on the scalp of patients with dandruff [J].Mycoses,2016,60(3):188-197.
[12] Ro B I,Dawson T L.The role of sebaceous gland activity and scalp microfloral metabolism in the etiology of seborrheic dermatitis and dandruff [J].Journal of Investigative Dermatology Symposium Procee-dings,2005,10(3):194.
[13] Katsuta Y,Iida T,Hasegawa K,et al.Function of oleic acid on epidermal barrier and calcium influx into keratinocytes is associated with N-methyl D-aspartate-type glutamate receptors [J].British Journal of Dermatology,2009,160(1):69-74.
[14] Ottaviani M,Alestas T,Flori E,et al.Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes:a possible role in acne vulgaris [J].Journal of Investigative Dermatology,2006,126(11):2430-2437.
[15] Camera E,Ludovici M,Galante M,et al.Comprehensive analysis of the major lipid classes in sebum by rapid resolution high-performance liquid chromatography and electrospray mass spectrometry [J].Journal of Lipid Research,2010,51(11):3377.
[16] Jourdain R,Moga A,Vingler P,et al.Exploration of scalp surface lipids reveals squalene peroxide as a potential actor in dandruff condition [J].Archives of Dermatological Research,2016,308(3):153-163.
[17] Cavusoglu N,Delattre C,Donovan M,et al.iTRAQ-based quantitative proteomics of stratum corneum of dandruff scalp reveals new insights into its aetiology and similarities with atopic dermatitis [J].Archives of Dermatological Research,2016,308(9):631-642.
[18] Gálvez M V,Aguilera J,Bernabó J L,et al.Human hair as a natural sun protection agent:a quantitative study [J].Photochemistry & Photobiology,2015,91(4):966-970.
[19] De L C,Picardo M,Breathnach A,et al.Lipoperoxidase activity of Pityrosporum:characterisation of by-products and possible rle in pityriasis versicolor [J].Experimental Dermatology,1996,5(1):49.
[20] Nazzaro-Porro M,Passi S,Picardo M,et al.Lipoxygenase activity of Pityrosporum in vitro and in vivo [J].Journal of Investigative Dermatology,1986,87(1):108.
[21] Deangelis Y M,Gemmer C M,Kaczvinsky J R,et al.Three etiologic facets of dandruff and seborrheic dermatitis:Malassezia fungi,sebaceous lipids,and individual sensitivity [J].Journal of Investigative Dermatology Symposium Proceedings,2005,10(3):295-297.
[22] Yamane Y,Moriyama K,Yasuda C,et al.New horny layer marker proteins for evaluating skin condition in atopic dermatitis [J].International Archives of Allergy & Immunology,2009,150(1):89-101.
[23] Denda M,Sato J,Tsuchiya T,et al.Low humidity stimulates epidermal DNA synthesis and amplifies the hyperproliferative response to barrier disruption:implication for seasonal exacerbations of inflammatory dermatoses [J].Journal of Investigative Dermatology,1998,111(5):873-878.
[24] 吴曰铭,徐崎,许晏.马拉色菌属生物学特性及分子生物学研究概况[J].疾病预防控制通报,2004,19(1):81-83.
[25] Saunders C W,Scheynius A,Heitman J.Malassezia fungi are specia-lized to live on skin and associated with dandruff,eczema,and other skin diseases [J].Plos Pathogens,2012,8(6):356-363.
[26] Warner R R,Schwartz J R,Boissy Y,et al.Dandruff has an altered stratum corneum ultrastructure that is improved with zinc pyrithione shampoo [J].Journal of the American Academy of Dermatology,2001,45(6):897-903.
[27] Sheu H M,Chao S C,Wong T W,et al.Human skin surface lipid film:an ultrastructural study and interaction with corneocytes and intercellular lipid lamellae of the stratum corneum [J].British Journal of Dermatology,1999,140(3):385-391.
[28] Darlenski R,Sassning S,Tsankov N,et al.Non-invasive in vivo methods for investigation of the skin barrier physical properties [J].European Journal of Pharmaceutics and Biopharmaceutics,2009,72(2):295.
[29] Kathy K B S,Darcy T,Henry J,et al.Epidermal changes associated with symptomatic resolution of dandruff:biomarkers of scalp health [J].International Journal of Dermatology,2011,50(1):102-113.
[30] Dang N N,Pang S G,Song H Y,et al.Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immuneresponse [J].Brazilian Journal of Medical and Biological Research,2015,48(1):39-45.
[31] Bonnist E Y,Pudney P D,Weddell L A,et al.Understanding the dandruff scalp before and after treatment:an in vivo Raman spectroscopic study [J].International Journal of Cosmetic Science,2014,36(4):347-354.
[32] Oakley A J,Yamada T,Liu D,et al.The identification and structural characterization of C7orf24 as γ-glutamyl cyclotransferase:an essential enzyme in the γ-glutamyl cycle [J].Journal of Biological Chemistry,2008,283(32):22031-22042.
[33] Jonca N,Leclerc E A,Caubet C,et al.Corneodesmosomes and corneodesmosin:from the stratum corneum cohesion to the pathophy-siology of genodermatoses [J].European Journal of Dermatology Ejd,2011,21(2):35-42.
[34] Voegeli R,Rawlings A V.Treatment of dry skin syndrome [M].Berlin:Springer Berlin Heidelberg,2012:149-178.
[35] List K,Kosa P,Szabo R,et al.Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway [J].American Journal of Pathology,2009,175(4):1453-1463.
[36] Singh B,Haftek M,Harding C R.Retention of corneodesmosomes and increased expression of protease inhibitors in dandruff [J].British Journal of Dermatology,2014,171(4):760-770.
[37] Simon M,Bernard D,Minondo A M,et al.Persistence of both peripheral and non-peripheral corneodesmosomes in the upper stratum corneum of winter xerosis skin versus only peripheral in normal skin [J].Journal of Investigative Dermatology,2001,116(1):23-30.
[38] Ekanayake-Mudiyanselage S,Jensen J M,Proksch E,et al.Expression of epidermal keratins and the cornified envelope protein involucrin is influenced by permeability barrier disruption [J].Journal of Investigative Dermatology,1998,111(3):517.
[39] Zhu S,Oh H S,Shim M,et al.C/EBPβ modulates the early events of keratinocyte differentiation involving growth arrest and keratin 1 and keratin 10 expression [J].Molecular & Cellular Biology,1999,19(10):7181-7190.
[40] 郑业华,杨恬,杨珂,等.人表皮发生的机制研究:C/EBP在调控体内外角质形成细胞分化中的作用[J].中国组织工程研究,2004,8(29):6374-6375.
[41] Melino G,Laurenzi V D,Catani M V,et al.The cornified envelope:a model of cell death in the skin [J].Results & Problems in Cell Differentiation,1998,24(4):175.
[42] Huber M,Rettler I,Bernasconi K,et al.Mutations of keratinocyte transglutaminase in lamellar ichthyosis [J].Science,1995,267(5197):525-528.
[43] Harder J,Schröder J M.RNase 7,a novel innate immune defense antimicrobial protein of healthy human skin [J].Journal of Biological Chemistry,2002,277(48):46779.
[44] Shendelman S,Jonason A,Martinat C,et al.DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation [J].Plos Biology,2004,2(11):362.
[45] Perkins M A,Cardin C W,Osterhues M A,et al.A non-invasive tape absorption method for recovery of inflammatory mediators to differen-tiate normal from compromised scalp conditions [J].Skin Research & Technology,2002,8(3):187-193.
[46] 潘永年,奚鑫.头皮屑中几种细胞因子的表达及其意义[J].现代医药卫生,2007,23(16):2386-2388.
[47] 陈淑君,方栩,王侠生.头皮屑中白介素1α、白介素1受体拮抗剂和白介素8的测定[J].中华皮肤科杂志,2007,40(2):92-94.
[48] Won L Y,Yung L S,Younghoon L,et al.Evaluation of expression of lipases and phospholipases of Malassezia restrictain patients with seborrheic dermatitis [J].Annals of Dermatology,2013,25(3):310.
[49] 韩阳,齐瑞群,张雨京,等.马拉色菌外分泌物的研究进展[J].国际皮肤性病学杂志,2017,43(3):185-188.