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日用化学工业 ›› 2021, Vol. 51 ›› Issue (8): 802-808.doi: 10.3969/j.issn.1001-1803.2021.08.016

• 分析与检测 • 上一篇    

液质联用法测定化妆品中16种抗感染类药物

沙丽娜1,杨光勇2,穆晓娟1,张明玥1,*()   

  1. 1.新疆维吾尔自治区药品检验研究院,新疆 乌鲁木齐 830054
    2.新疆维吾尔自治区产品质量监督检验研究院,新疆 乌鲁木齐 830011
  • 收稿日期:2020-12-18 修回日期:2021-08-01 出版日期:2021-08-22 发布日期:2021-08-24
  • 通讯作者: 张明玥

Determination of 16 kinds of anti-infective drugs in cosmetics by LC-MS/MS

Sha Lina1,Yang Guangyong2,Mu Xiaojuan1,Zhang Mingyue1,*()   

  1. 1. XinJiang Uygur Autonomous Region Institute of Drug Control,Urumqi, Xinjiang 830054, China
    2. Xinjiang Uygur Autonomous Region Product Quality Supervision and Inspection Institute, Urumqi, Xinjiang 830011, China
  • Received:2020-12-18 Revised:2021-08-01 Online:2021-08-22 Published:2021-08-24
  • Contact: Mingyue Zhang

摘要:

建立了采用液质联用法(liquid chromatography-tandem mass spectrometry, LC-MS/MS)检测化妆品中氟康唑等16种抗感染类药物的方法。结果表明,酮康唑线性范围为0.50~25 μg/g,其余15种线性范围为0.10~5.0 μg/g,相关系数r均大于0.99;精密度试验RSD均小于1.8%;酮康唑检出质量浓度为25 ng/mL,其余15种组分检出质量浓度均小于10 ng/mL;回收率试验结果在86.0%~112.4%范围之内。说明本方法具有良好的线性、精密度和回收率,适用于化妆品中氟康唑等16种抗感染类药物的检测。本方法结合国标方法,增加了8种组分的检测,加强了化妆品的监管力度,降低了化妆品的安全风险。

关键词: 液相色谱-串联质谱法, 化妆品, 抗感染类药物

Abstract:

A method based on liquid chromatography tandem mass spectrometry (LC-MS/MS) was established for the determination of 16 kinds of anti-infective drugs in cosmetics. The linear range of ketoconazole is 0.50-25 μg/g, and the linear range of the other 15 components is between 0.10-5.0 μg/g. The correlation coefficients are all greater than 0.99, and the RSD of precision test is less than 1.8%. The detection mass concentration of ketoconazole is 25 ng/mL, and the detection mass concentrations of the other 15 components are less than 10 ng/mL. The recoveries are in the range of 86.0%-112.4%. The method has good linearity, precision and recovery. It is suitable for the detection of 16 kinds of anti-infective drugs in cosmetics. Combined with the national standard method, this method adds the detection of 8 components, strengthens the supervision of cosmetics and reduces the safety risk of cosmetics.

Key words: LC-MS/MS, cosmetic, anti-infective drugs

中图分类号: 

  • TQ658