茶皂素洗手液的制备及抑菌性能研究

doi:10.3969/j.issn.1001-1803.2021.01.005

日用化学工业 ›› 2021, Vol. 51 ›› Issue (1): 28-31.doi: 10.3969/j.issn.1001-1803.2021.01.005

茶皂素洗手液的制备及抑菌性能研究

高园¹(),傅玄¹,袁瑞¹,马英剑²,冯建国²,刘岐¹()

1.扬州大学医学院,江苏扬州 225001
2.扬州大学园艺与植物保护学院,江苏扬州 225009

收稿日期:2020-06-14 修回日期:2021-01-05 出版日期:2021-01-22 发布日期:2021-01-20
通讯作者: 刘岐
作者简介:高园（1997-）,女,吉林人,硕士研究生,电话：13844642118,E-mail: 1804289865@qq.com。
基金资助:
扬州市自然科学基金资助项目(YZ2018100);江苏省中医药科技发展计划项目(YB201994);扬州大学大学生科创基金项目(X20190582)

Preparation and bacteriostatic properties of tea saponin hand sanitizer

GAO Yuan¹(),FU Xuan¹,YUAN Rui¹,MA Ying-jian²,FENG Jian-guo²,LIU Qi¹()

1. Medical College of Yangzhou University, Yangzhou, Jiangsu 225001, China
2. School of Horticulture and Plant Protection, Yangzhou University, Yangzhou, Jiangsu 225009, China

Received:2020-06-14 Revised:2021-01-05 Online:2021-01-22 Published:2021-01-20
Contact: Qi LIU

摘要/Abstract

摘要：

以茶皂素（TS）为主要抑菌成分,脂肪醇聚氧乙烯醚硫酸钠（AES）和椰油酰胺丙基甜菜碱（CAB）为表面活性剂,通过单因素实验筛选抑菌洗手液配方,并对洗手液理化指标及抑菌性能进行测定。结果表明：优化后的TS洗手液由质量分数为15% TS,10% AES,20% CAB,3%增稠剂886+6502（质量比1∶1）,3%甘油,0.1%香精,0.2%柠檬酸和余量去离子水组成,该洗手液黏度适中,起泡性能优异,对大肠杆菌和金黄色葡萄球菌抑菌性能良好。

关键词: 茶皂素, 洗手液, 制备, 抑菌

Abstract:

Tea saponin （TS） was used as the main bacteriostatic component, and fatty alcohol polyoxyethylene ether sulfate （AES） and cocoamidopropyl betaine （CAB） were used as surfactants. The formulation of bacteriostatic hand sanitizer was screened by single factor test, and the physicochemical indexes and bacteriostatic properties of the hand sanitizer were determined. The results show that the mass fraction of optimized TS hand sanitizer is composed of 15% TS, 10% AES, 20% CAB, 3% thickener 886 and 6502 （mass ratio 1∶1）, 3% glycerin, 0.1% flavor, 0.2% citric acid and residual deionized water. The hand sanitizer has moderate viscosity, excellent foaming performance and good bacteriostatic performance against Escherichia coli （E.coil） and Staphylococcus aureus （S.aureus）.

Key words: tea saponin, hand sanitizer, preparation, bacteriostasis

中图分类号:

TQ423

高园,傅玄,袁瑞,马英剑,冯建国,刘岐. 茶皂素洗手液的制备及抑菌性能研究[J]. 日用化学工业, 2021, 51(1): 28-31.

GAO Yuan,FU Xuan,YUAN Rui,MA Ying-jian,FENG Jian-guo,LIU Qi. Preparation and bacteriostatic properties of tea saponin hand sanitizer[J]. China Surfactant Detergent & Cosmetics, 2021, 51(1): 28-31.

图/表 8

图1

表1

表2

表3

表4

表5

表6

表7

参考文献 18

[1]	Tartari E, Pires D, Bellissimo-Rodrigues F, et al. The global hand-sanitizing relay: promoting hand hygiene through innovation[J]. Journal of Hospital Infection, 2017,95(2) : 189-93. doi: 10.1016/j.jhin.2016.11.003
[2]	Yang Lihua, Zhang Yong, Zhao Rui, et al. Analysis of the current situation of hand sanitizer use in public places and its hygienic quality[J]. Chinese Journal of Health Laboratory Technology, 2016,26(19) : 2859-2860, 2864.
[3]	Zhang Zhen, Zhang Chunyan, Sun Shanshan, et al. Experimental study on new skin care antibacterial hand sanitizer[J]. Guangzhou Chemical Industry, 2015,43(15) : 99-101.
[4]	Qiang Pengtao, Yu Wen. Current situation and development trend of hand sanitizer formulation technology[J]. China Cleaning Industry, 2015 (5) : 31-35.
[5]	Ren Huijing. Extraction, purification and application of tea saponin in daily chemical products[D]. Shanghai: Shanghai Ocean University, 2016.
[6]	Shang Congshan, He Zhongjing. Development of a new type of artemisia argyi antibacterial hand sanitizer[J]. Science & Technology Ecnony Market, 2016 (6) : 14-15.
[7]	Song Bo, He Can, Wen Guoqin, et al. Study on the bacteriostatic effect of three kinds of hand sanitizers[J]. Shandong Chemical Industry, 2019,48(10) : 24-26, 28.
[8]	Zhang Shangqian, Zhou Xiantai, Deng Yanying, et al. Study on the preparation of purslane antibacterial hand sanitizer[J]. Guangzhou Chemical Industry, 2020,48(3) : 84-87.
[9]	Zhao Yuxuan, Jiang Ge, Hao Zitong, et al. Study on the preparation of gleditsia sinensis natural hand sanitizer[J]. Chemical Management, 2020 (14) : 193-194.
[10]	Sun Jinyi, Cai Chunhui, Liang Rong, et al. Purification of tea saponin and inhibition of tyrosinase activity[J]. China Surfactant Detergent &Cosmetics, 2017,47(6) : 312-316, 340.
[11]	Diao Chunhua. Preparation of antibacterial hand sanitizer with active ingredients of tea[D]. Hangzhou: Zhejiang Agriculture & Forestry University, 2018.
[12]	Xu Dan, Ke Shiting, Lin Zhumei, et al. Development of hand sanitizer with Eucheuma extract[J]. Chinese Journal of Disinfection, 2018,35(5) : 329-332.
[13]	Li Minshan, Zheng Cheng, Mao Taoyan, et al. Preparation and antibacterial properties of quaternary ammonium hand sanitizer[J]. China Surfactant Detergent & Cosmetics, 2016,46(2) : 89-91, 100.
[14]	Xie Qingfan, Li Yuanming, Chen Shifang, et al. Preparation, purification and surface activity of crude tea saponin[J]. Jiangsu Agricultural Sciences, 2014 (4) : 206-208.
[15]	Tai Xiumei, Liu Xiaoying, Du Zhiping, et al. Formulation and performance of bacteriostasis liquid detergent[J]. China Surfactant Detergent & Cosmetics, 2016,46(3) : 141-144.
[16]	Tang Weiyue. Study on properties of didecyl dimethyl quaternary ammonium salt with different counter ions[D]. China Research Institute of Daily Chemical Industry, 2016.
[17]	Jiang Xiaodong, Feng Kejue, Yang Xiaoping, et al. In vitro antifungal activity and mechanism of action of tea polyphenols and tea saponin against rhizopus stolonifer[J]. Journal of Molecular Microbiology and Biotechnology, 2015,25(4) : 269-76. doi: 10.1159/000430866 pmid: 26138353
[18]	Zhao Ying, Su Ruiqi, Zhang Wenting, et al. Antibacterial activity of tea saponin from camellia oleifera shell by novel extraction method[J]. Industrial Crops and Products, 2020,153:112604.

m（AES） :m（CAB）	w（TS）/%	w（增稠剂886+6502）/%
1:1	10	1
1:2	15	2
2:1	20	3

m（AES） :m（CAB）	w（TS）/%	w（增稠剂886+6502）/%	起泡性能
m（AES） :m（CAB）	w（TS）/%	w（增稠剂886+6502）/%	泡沫高度/mm	泡沫消减所需时间/s
1:1	10.0	3	112	23
1:2	10.0	3	123	29
2:1	10.0	3	145	38

m（AES） :m（CAB）	w（TS）/%	w（增稠剂886+6502）/%	抑菌圈均值/mm
1:2	10	3	11.2
1:2	15	3	15.8
1:2	20	3	19.6

m（AES） :m（CAB）	w（TS）/%	w（增稠剂886+6502）/%	η/（mPa·s）
1:2	15.0	1	2 282
1:2	15.0	2	2 676
1:2	15.0	3	3 308

泡沫高度/mm		泡沫消减所需时间/s
测试值	标准值	测试值	标准值
125	≥100	30	>25
121		28
119		29

茶皂素洗手液的制备及抑菌性能研究

Preparation and bacteriostatic properties of tea saponin hand sanitizer

RichHTML

PDF (PC)

赞

可视化

摘要/Abstract

引用本文

使用本文

图/表 8

参考文献 18

相关文章 15

Metrics

本文评价

推荐阅读 10

η/（mPa·s）
TS洗手液	对比洗手液1	对比洗手液2
3 289	3 380	3 234
3 270	3 382	3 238
3 297	3 385	3 235

组别	S. aureus抑菌率/%	E. coil抑菌率/%
空白组	0	0
TS洗手液	99	99.9
对比洗手液1	72.3	79.6
对比洗手液2	75.1	80.5
不加TS成分洗手液	8.1	7.2

[1]	孔令鸟, 洪郑, 方银军. Ce改性MgO催化硬脂酸甘油三酯甘油解制备单甘酯的研究[J]. 日用化学工业（中英文）, 2023, 53(5): 517-522.
[2]	孔秋婵, 蒋佳欣, 夏高辉, 龚盛昭. 抗菌纤维的抑菌活性及其在面膜产品中的应用研究[J]. 日用化学工业（中英文）, 2023, 53(5): 538-543.
[3]	郝晴, 吴二敏, 毕永贤, 刘金俊, 孔德承, 成志伟. 莲子心总黄酮多元醇提取工艺筛选及其性能研究[J]. 日用化学工业（中英文）, 2023, 53(4): 398-407.
[4]	李晓敏. 基于酶催化合成单甘油酯工艺优化及抑菌活性研究[J]. 日用化学工业（中英文）, 2023, 53(2): 180-186.
[5]	颜少慰, 高畅, 左丽娜. 高浓度人参皂苷Rg3的制备及其在化妆品中的应用[J]. 日用化学工业（中英文）, 2023, 53(1): 24-31.
[6]	于昕琪,隋振全,徐桂云,范金石. 常用化妆品成型技术（Ⅲ）——液固飞扬：气雾剂和喷雾剂[J]. 日用化学工业, 2022, 52(9): 930-936.
[7]	刘丰,罗俊,王晓炜,应国红. 含发酵产物类化妆品微生物检查方法适用性研究[J]. 日用化学工业, 2022, 52(8): 839-843.
[8]	冯云,石晶,包杰,郝旸,徐桂云,范金石. 常用化妆品成型技术（Ⅰ）— 油水一家：乳剂[J]. 日用化学工业, 2022, 52(7): 696-703.
[9]	王长运,郝旸,樊建茹,唐文俊,徐桂云,范金石. 天然生物质材料的制备、性质与应用（Ⅵ）——可直可支的植物储能多糖：淀粉[J]. 日用化学工业, 2022, 52(6): 585-593.
[10]	樊建茹,亓玺,郝旸,王长运,徐桂云,范金石. 天然生物质材料的制备、性质与应用（Ⅴ）——生物相容性良好的功能蛋白质材料：胶原蛋白[J]. 日用化学工业, 2022, 52(5): 476-485.
[11]	沈胡驰,杨莉,陈殿松,马铃,杨井国,王靖. 茶皂素的脱色及控油功效研究[J]. 日用化学工业, 2022, 52(5): 486-492.
[12]	林显佳,曹妍,罗文薏,林震,张志国,温燕梅. 含十二烷基二亚丙三胺抗菌洗手液的制备及抗菌性能探究[J]. 日用化学工业, 2022, 52(4): 376-382.
[13]	石晶,冯云,包杰,樊建茹,徐桂云,范金石. 天然生物质材料的制备、性质与应用（Ⅲ）——医护两用的糖胺聚糖：透明质酸[J]. 日用化学工业, 2022, 52(3): 237-244.
[14]	王亚魁,鞠洪斌,耿涛,曹玉朋,杨伟光,丁慧,姜亚洁. 有机反离子十六烷基三甲基铵的表面活性及应用性能[J]. 日用化学工业, 2022, 52(2): 116-123.
[15]	毛金超,隋振全,徐桂云,范金石. 天然生物质材料的制备、性质与应用（Ⅱ）——pH敏感型功能海洋多糖：海藻酸钠[J]. 日用化学工业, 2022, 52(2): 124-133.