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日用化学工业（中英文）

日用化学工业 ›› 2022, Vol. 52 ›› Issue (4): 376-382.doi: 10.3969/j.issn.1001-1803.2022.04.005

• 开发与应用 • 上一篇    下一篇

含十二烷基二亚丙三胺抗菌洗手液的制备及抗菌性能探究

林显佳1,曹妍1,罗文薏1,林震1,张志国2,温燕梅1,*()   

  1. 1. 广东海洋大学,广东 湛江 524000
    2. 诺力昂化学品（博兴）有限公司,山东 博兴 256500
  • 收稿日期:2021-06-11 修回日期:2021-03-21 出版日期:2022-04-22 发布日期:2022-04-25
  • 通讯作者: 温燕梅
  • 基金资助:
    广东省创新强校工程项目(230419054);广东省基础与应用基础研究基金项目(2021A1515010304)

Study on the preparation and antibacterial properties of antibacterial hand sanitizers containing dodecyl dipropylene triamine

Lin Xianjia1,Cao Yan1,Luo Wenyi1,Lin Zhen1,Zhang Zhiguo2,Wen Yanmei1,*()   

  1. 1. Guangdong Ocean University, Zhanjiang, Guangdong 524000, China
    2. Nouryon Chemicals （Boxing） Co., Ltd., Boxing, Shandong 256500, China
  • Received:2021-06-11 Revised:2021-03-21 Online:2022-04-22 Published:2022-04-25
  • Contact: Yanmei Wen

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摘要：

为了制备含十二烷基二亚丙三胺（DDT）抗菌成分的洗手液,以AES-6501-NaCl、CAB-35-AES-NaCl、丙烯酸-2-丙烯酰胺-2-甲基丙磺酸、6502-NaCl（Na2SO4）和聚乙二醇6000双硬脂酸酯（638）系统为研究对象,在这些体系中分别加入等质量分数的DDT,以体系的黏度与透光率为指标,来判断增稠体系与DDT的兼容性强弱。在此基础上,进一步进行单因素试验,优化洗手液的配方,制备出含DDT抗菌成分的洗手液。再对制得的洗手液进行了性能检测,包括稳定性、黏度、活性物含量、pH值、起泡高度及杀菌性能。实验结果表明：除638体系与DDT有一定兼容性外,其余增稠体系兼容性皆较差。制得的含DDT抗菌成分的洗手液各项性能指标均符合国家标准,且该复配洗手液在2 min的作用条件下对大肠杆菌、金黄色葡萄球菌平均杀菌率分别达到97.63%和98.96%。

关键词: 十二烷基二亚丙三胺, 洗手液, 杀菌, 增稠

Abstract:

The hand sanitizers containing dodecyl dipropylene triamine （DDT, antibacterial component） were prepared with the thickening systems such as AES-6501-NaCl, CAB-35-AES-NaCl, acrylic acid-2-acrylamide-2-methylpropanesulfonic acid, 6502-NaCl （Na2SO4）, and polyethylene glycol 6000 distearate （638）. The same mass fraction of DDT was added to these systems respectively. Then the viscosity and transmittance were investigated to judge the compatibility of these thickening systems with DDT. Single factor experiments were further carried out and the formula was optimized. The hand sanitizer containing DDT was thus prepared. Then the properties of the hand sanitizer were tested, including stability, viscosity, active substance content, pH value, foam height and bactericidal performance. The experimental results show that, the 638 system is compatible with DDT, while other thickening systems are not compatible with DDT. After high-temperature and low-temperature stability tests, the antibacterial hand sanitizer containing DDT shows no phase separation, no precipitation and no obvious color change, indicating that it has good stability. The viscosity is 2 767 Pa·s, which proves that the hand sanitizer can stay on the skin for a long time. The average value of active substance content is 10.2% and the pH value is 5.5, which all meet the national standard. The average bactericidal rates of the hand sanitizer against Escherichia coli and Staphylococcus aureus in 2 minutes were 97.63% and 98.96%, respectively.

Key words: dodecyl dipropylene triamine, hand sanitizer, sterilization, thickening

中图分类号: 

  • TQ649