黄金微针联合可复美面膜对玫瑰痤疮患者症状、皮肤生理功能及预后的影响

doi:10.3969/j.issn.1001-1803.2022.07.009

摘要/Abstract

摘要：

研究黄金微针联合可复美面膜对玫瑰痤疮患者症状、皮肤生理功能、预后的影响。选取2019年8月~2021年8月本院142例玫瑰痤疮患者,随机数字表法分组,各71例。对照组采取黄金微针,观察组基于对照组采取可复美面膜,均治疗4周。统计两组治疗效果、不良反应及治疗前后症状评分、皮肤生理指标（经皮水分流失量（TEWL）、表皮含水量、油脂）、角质层完整性指标（粘脱蛋白含量、丝氨酸蛋白活性）、痤疮特异性生活质量量表（Acne-QOL）。结果显示,观察组治疗总有效率高于对照组（P<0.05）;治疗2周后、4周后观察组红斑、潮红、毛细血管扩张评分均低于对照组（P<0.05）;治疗4周后观察组TEWL、丝氨酸蛋白活性、粘脱蛋白含量低于对照组,油脂、表皮含水量高于对照组（P<0.05）;观察组不良反应发生率与对照组比较,差异无统计学意义（P>0.05）;治疗4周后两组Acne-QOL评分均高于治疗前（P<0.05）。黄金微针联合可复美面膜有助于改善玫瑰痤疮患者皮肤生理功能,修复角质层,缓解临床症状,且安全性较高。

关键词: 玫瑰痤疮, 可复美面膜, 黄金微针, 皮肤生理功能, 预后

Abstract:

To investigate the effect of gold microneedle combined with Kefumei mask on symptoms, skin physiological function and prognosis of patients with rosacea were studied. A total of 142 patients with rosacea in our hospital from August 2019 to August 2021 were selected and randomly divided into different groups, with 71 cases in each group. The control group took gold micro-needling, while the observation group took Kefumei mask after gold micro-needling treatment, and both were treated for 4 weeks. The treatment effect, adverse reactions, symptom scores before and after treatment were recorded, including skin physiological indexes （transepidermal water loss （TEWL）, epidermal water content, oil）, stratum corneum integrity indexes （mucoprotein content, serine protein activity）, and Acne-specific quality of life scale （Acne-QOL）. The total effective rate of treatment in the observation group was higher than that in the control group （P<0.05）. After 2 weeks and 4 weeks of treatment, the scores of erythema, flushing and telangiectasia in the observation group were lower than those in the control group （P<0.05）. After 4 weeks of treatment, the contents of TEWL, serine protein activity and mucoprotein in the observation group were lower than those in the control group, and the oil and epidermal water contents were higher than those in the control group （P<0.05）. There was no significant difference in the incidence of adverse reactions between the observation group and the control group （P>0.05）. After 4 weeks of treatment, the Acne-QOL scores in both groups were higher than those before treatment （P<0.05）. Gold microneedle combined with Kefumei mask can help to improve the physiological function of the skin in patients with rosacea, repair the stratum corneum, relieve clinical symptoms, improve the prognosis, and has high safety.

Key words: rosacea, Kefumei mask, gold microneedling, skin physiological function, prognosis

中图分类号:

TQ658

崔秀华,高伟涛,武庆梅,苏子新,孙崇秋. 黄金微针联合可复美面膜对玫瑰痤疮患者症状、皮肤生理功能及预后的影响[J]. 日用化学工业, 2022, 52(7): 744-749.

Cui Xiuhua,Gao Weitao,Wu Qingmei,Su Zixin,Sun Chongqiu. Effect of gold microneedle combined with Kefumei mask on symptoms, skin physiological function and prognosis of patients with rosacea[J]. China Surfactant Detergent & Cosmetics, 2022, 52(7): 744-749.

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组别	例数	性别（男/女）	年龄/岁	病程/月	累及部位/[例（%）]				病情程度/[例（%）]
组别	例数	性别（男/女）	年龄/岁	病程/月	额部	鼻部	双颊	口周	中度	重度
观察组	71	28/43	32.15±4.18	18.34±1.87	12（16.90%）	24（33.80%）	31（43.66%）	4（5.64%）	36（50.70%）	35（49.30%）
对照组	71	30/41	30.96±5.33	17.97±2.46	10（14.08%）	26（36.62%）	29（40.85%）	6（8.45%）	40（56.34%）	31（43.66%）
χ²/t		0.117	1.480	1.010	0.728				0.453
P		0.733	0.141	0.315	0.866				0.501

症状	0分	1分	2分	3分
毛细血管扩张	正常	轻度（扩张面积不足面部10%）	中度（扩张面积10%~29%）	重度（扩张面积超过面部30%）
红斑	正常	轻度	中度	重度（遍及全脸）
潮红	正常	轻度	中度	重度（持续、频繁、明显）

组别	例数	无效/[例（%）]	有效/[例（%）]	显效/[例（%）]	总有效率/[例（%）]
观察组	71	10（14.09%）	23（35.21%）	37（50.70%）	61（85.91%）
对照组	71	20（28.17%）	26（36.62%）	25（35.21%）	51（71.83%）
χ²					4.226
P					0.040

组别		例数	评分/分
组别		例数	红斑	潮红	毛细血管扩张
观察组	治疗前	71	2.33±0.21	2.40±0.22	2.36±0.23
	治疗2周后		1.30±0.15^ab	1.43±0.16^ab	1.26±0.18^ab
	治疗4周后		0.61±0.06^ac	0.64±0.05^ac	0.70±0.10^ac
对照组	治疗前	71	2.28±0.24	3.34±0.18	2.41±0.17
	治疗2周后		1.49±0.18^a	1.65±0.15^a	1.46±0.13^a
	治疗4周后		0.76±0.10^a	0.81±0.08^a	0.84±0.14^a

组别		例数	评分/分
组别		例数	TEWL	油脂	表皮含水量
观察组	治疗前	71	22.10±3.38	68.20±6.68	55.42±5.46
	治疗2周后		17.62±2.57^a	71.13±7.24^a	60.03±6.12^a
	治疗4周后		11.55±1.68^ab	79.92±7.88^ab	70.30±6.68^ab
对照组	治疗前	71	20.98±4.46	66.87±7.59	56.13±4.63
	治疗2周后		17.35±3.42^a	70.87±7.92^a	58.95±7.45^a
	治疗4周后		14.22±2.01^a	76.65±8.24^a	67.75±7.12^a