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日用化学工业 ›› 2020, Vol. 50 ›› Issue (4): 275-281.doi: 10.3969/j.issn.1001-1803.2020.04.011

• 分析与检测 • 上一篇    下一篇

QuEChERS-HPLC-MS/MS法测定4种化妆品基质中15种硝基咪唑类非法添加药物的基质效应研究

陈岑,颜琳琦,程巧鸳()   

  1. 浙江省食品药品检验研究院,浙江 杭州 310052
  • 收稿日期:2019-07-14 修回日期:2020-03-25 出版日期:2020-04-22 发布日期:2020-04-24
  • 通讯作者: 程巧鸳
  • 作者简介:陈 岑(1987-),男,浙江杭州人,主管药师,硕士,电话:18058146625,E-mail:chencen30603086@163.com。
  • 基金资助:
    浙江省食品药品监管系统科技计划项目(2019015)

Research of matrix effect of 15 nitroimidazole drugs illegally added in 4 kinds of cosmetic matrices by QuEChERS-HPLC-MS/MS methods

CHEN Cen,YAN Ling-qi,CHENG Qiao-yuan()   

  1. Zhejiang Institute for Food and Drug Control, Hangzhou, Zhejiang 310052, China
  • Received:2019-07-14 Revised:2020-03-25 Online:2020-04-22 Published:2020-04-24
  • Contact: Qiao-yuan CHENG

摘要:

建立了QuEChERS-HPLC-MS/MS法测定4种化妆品基质中15种硝基咪唑类非法添加药物的方法,研究了在该方法下水剂、散粉、乳液和膏霜对15种硝基咪唑类药物的基质效应,并探讨了基质种类、基质质量浓度和药物质量浓度对基质效应的影响。结果表明:4种基质对15种硝基咪唑类药物均存在不同程度的基质效应,且多呈基质抑制效应,基质种类、基质质量浓度和药物质量浓度均会影响基质效应。因此,在日常检测化妆品中硝基咪唑类非法添加药物时要考虑基质效应对检测结果的影响。对于呈现弱基质效应的水剂和散粉类基质,可根据实际需求忽略其基质效应的影响;而对于基质效应明显的乳液和膏霜类基质,建议采用基质匹配标准曲线进行定量分析,以确保检测结果的准确性。

关键词: 基质效应, 高效液相色谱-串联质谱法, 化妆品, 硝基咪唑类, 非法添加

Abstract:

A QuEChERS coupled with high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method was developed for the detection of 15 nitroimidazole drugs illegally added in 4 kinds of cosmetic matrices. The matrix effects of 15 nitroimidazole drugs in water aqua, powder, lotion and cream, together with the influences of matrix type, matrix mass concentration and drug mass concentration on the matrix effects were discussed. The result show that the 4 kinds of cosmetic have different degrees of matrix effects on 15 nitroimidazole drugs, and most of them are matrix inhibitory effects, which are impacted by matrix type, matrix mass concentration and drug mass concentration. Therefore, it’s crucial to take matrix effect into consideration during the detection of the nitroimidazoles illegally added in cosmetic products. For some matrices with weak matrix effects, such as water aqua and powder, the matrix effects can be ignored according to actual needs. For emulsions and cream substrates with significant matrix effects, it is recommended to use a matrix-matched standard curve for quantitative analysis to ensure the accuracy of the test results.

Key words: matrix effect, HPLC-MS/MS, cosmetics, nitroimidazoles, illegally added

中图分类号: 

  • TQ658