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日用化学工业（中英文）

日用化学工业 ›› 2018, Vol. 48 ›› Issue (7): 415-418.doi: 10.13218/j.cnki.csdc.2018.07.010

• 分析与检测 • 上一篇    下一篇

HPLC法测定化妆品中12种邻苯二甲酸酯类化合物

蔡霞1,黄艳婷1,符美燕2,蒙晓3,梁祈1   

  1. 1.广东省药品检验所,广东 广州 510180;
    2.广州汇高生物科技有限公司,广东 广州 510510;
    3.广州医科大学附属第一医院,广东 广州 510120
  • 出版日期:2018-07-22 发布日期:2019-03-22
  • 通讯作者: 梁祈,主任药师,博士,电话:(020)81853845,Email:yliangqi@yeah.net。
  • 作者简介:蔡霞(1983-),女,江西人,主管药师,硕士,电话:(020)81886363,Email:403083820@qq.com。

Determination of 12 kinds of phthalates in cosmetics by HPLC

CAI Xia1,HUANG Yan-ting1,FU Mei-yan2,MENG Xiao3,LIANG Qi1   

  1. 1.Guangdong Institute for Drug Control,Guangzhou,Guangdong 510180,China;
    2.Guangzhou Phgo Biotechnology Co.,Ltd.,Guangzhou,Guangdong 510510,China;
    3.The First Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong 510120,China
  • Online:2018-07-22 Published:2019-03-22

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摘要： 采用亚3 μm填料的Agilent Poroshell 120 EC-C18色谱柱(100 mm×4.6 mm,2.7 μm)对化妆品中的12种邻苯二甲酸酯类化合物进行分析,以甲醇-乙腈-水为流动相,梯度洗脱,检测波长230 nm。结果表明,12种成分在10 min内完成分离,在5.0~100 mg/L范围内线性关系良好。方法检出限为1.0~40.0 mg/kg,定量下限为3.5~150.0 mg/kg,平均加样回收率在89.4%~107.1%之间,RSD在0.3%~1.5%之间。

关键词: 化妆品, 塑化剂, 高效液相色谱法, 邻苯二甲酸酯类化合物, 亚3 μm填料

Abstract: The chromatographic separation of 12 kinds of phthalates in cosmetics was achieved on an Agilent Poroshell 120 EC-C18(100 mm×4.6 mm,2.7 μm) filled with particles of sub-3 μm,with the mobile phase of methanol-acetonitrile-water by gradient elution,at the detection wavelength of 230 nm.The results indicate that 12 components are completely separated in 10 min,and the linear relationship is good in the range of 5.0-100 mg/L.The detection limits range from 1.0 mg/kg to 40.0 mg/kg,and the lower limits of quantitation range from 3.5 mg/kg to 150.0 mg/kg.The average recoveries are in the range of 89.4%-107.1%,and RSDs are in the range of 0.3%-1.5%.

Key words: cosmetic, plasticizer, high performance liquid chromatography, phthalate, sub-3 μm filler

中图分类号: 

  • TQ658