日用化学工业(中英文) ›› 2023, Vol. 53 ›› Issue (6): 679-685.doi: 10.3969/j.issn.2097-2806.2023.06.010
收稿日期:
2022-06-23
修回日期:
2023-05-29
出版日期:
2023-06-22
发布日期:
2023-06-25
基金资助:
Zhu Hairong,Sun Shengmin,Zhang Juan*(),Liu Shuang,Liu Qianqian,Zou Huiling
Received:
2022-06-23
Revised:
2023-05-29
Online:
2023-06-22
Published:
2023-06-25
Contact:
*Tel.: +86-13361019675, E-mail: 摘要:
化妆品中的防腐剂在抑制微生物生长、延长产品保质期方面发挥了重要作用,但其使用不当会损害人体健康并对环境和生态安全造成潜在危害。随着化妆品安全事件的频发,居民消费安全意识的提升和行业监管法规趋严,防腐剂的添加状况成为社会各界的关注焦点。文章总结了当前化妆品中防腐剂的使用现状,梳理了近年来常规检测技术在化妆品中防腐剂领域的最新应用,介绍了高效液相色谱-电感耦合等离子体质谱法和激光解吸附离子化质谱等新型检测手段。分析了化妆品中防腐剂的市场发展前景和检测技术发展方向,为今后化妆品中防腐剂的监管和高通量快速检测提供借鉴。
中图分类号:
朱海荣, 孙胜敏, 张娟, 刘爽, 刘倩倩, 邹惠玲. 化妆品中防腐剂的应用现状及检测技术研究进展[J]. 日用化学工业(中英文), 2023, 53(6): 679-685.
Zhu Hairong, Sun Shengmin, Zhang Juan, Liu Shuang, Liu Qianqian, Zou Huiling. Recent progress on the application status of cosmetic preservatives and their detection technology[J]. China Surfactant Detergent & Cosmetics, 2023, 53(6): 679-685.
表1
国内化妆品中防腐剂相关检测技术国家标准"
序号 | 标准号 | 标准名称 | 测试对象 | 检测手段 | 检出限/(mg/kg) |
---|---|---|---|---|---|
1 | GB/T 24800.11-2009 | 化妆品中防腐剂苯甲醇的测定 气相色谱法[ | 膏霜、乳液、洗发水、染发剂等化妆品 | 气相色谱法 | 13 |
2 | GB/T 26517-2011 | 化妆品中二十四种防腐剂的测定 高效液相色谱法[ | 膏霜、乳液、化妆水等皮肤护理类化妆品 | 液相色谱法 | 0.5~100 |
3 | GB/T 29666-2013 | 化妆品用防腐剂 甲基氯异噻唑啉酮和甲基异噻唑啉酮与氯化镁及硝酸镁的混合物[ | 洗发水、沐浴液、洗面奶等清洁类化妆品 | 液相色谱法 | — |
4 | GB/T 35800-2018 | 化妆品中防腐剂己脒定和氯己定及其盐类的测定 高效液相色谱法[ | 水剂、膏霜、香波、散粉和唇膏类化妆品 | 液相色谱法 | 20 |
5 | GB/T 35948-2018 | 化妆品中7种4-羟基苯甲酸酯的测定 高效液相色谱法[ | 膏霜类、乳液类、啫喱类、水类、粉类、蜡基类化妆品 | 液相色谱法 | 2 |
6 | GB/T 39993-2021 | 化妆品中限用防腐剂二甲基噁唑烷、7-乙基双环噁唑烷和5-溴-5-硝基-1,3-二噁烷的测定[ | 水剂类、水包油类、油包水类化妆品 | 气相色谱-质谱联用法、液相色谱法 | 15 |
[1] |
Matwiejczuk N, Galicka A, Brzóska M. Review of the safety of application of cosmetic products containing parabens[J]. Journal of Applied Toxicology, 2020, 40 (1) : 176-210.
doi: 10.1002/jat.3917 pmid: 31903662 |
[2] | Burnett C L, Bergfeld W F, Belsito D V, et al. Amended safety assessment of methylchloroisothiazolinone and methylisothiazolinone as used in cosmetics[J]. International Journal of Toxicology, 2021, 40 (1 suppl) : 20-33. |
[3] | Huang Xianglu, Lu Jiacan, Xing Shuxia, et al. Research progress on toxicology and risk assessment of zinc pyrithione as cosmetics ingredient[J]. China Surfactant Detergent & Cosmetics, 2021, 51 (12) : 1235-1241. |
[4] | Tanaka T, Oishi M, Okazaki M. The relationship between the preservative efficacy and cytotoxicity of two common preservatives used in cosmetics[J]. Journal of Oral Tissue Engineering, 2018, 15 (3) : 186-192. |
[5] | Boyer I J, Heldreth B, Bergfeld W F, et al. Amended safety assessment of formaldehyde and methylene glycol as used in cosmetics[J]. International Journal of Toxicology, 2013, 32 (4 suppl) : 5-32. |
[6] | The State Food and Drug Administration. Safety and technical standards for cosmetics (2015 Edition)[S]. Beijing: The State Food and Drug Administration, 2016. |
[7] | Zhang Xing, Ji Jing. Review on the regulations and status quo of preservatives applied in infant cosmetics[J]. China Cleaning Industry, 2020 (6) : 43-48. |
[8] | Cao Mengcen, Feng Tingting, Zhang Xiaochai, et al. Investigation on preservatives use in commercial cosmetics[J]. Journal of Environmental Hygiene, 2017, 7 (4) : 296-300. |
[9] | Pan Yao, Ge Rujiao, Wan Qingqing, et al. Investigation on the use of preservatives in cosmetic masks[J]. Chinese Journal of Health Laboratory, 2019, 29 (21) : 2571-2574, 2578. |
[10] | Ru Ge, Wang Ke, Zheng Rong. Investigation on the addition of formaldehyde and formaldehyde releasing preservatives in 550 cosmetics[J]. Journal of Environment and Health, 2018, 35 (7) : 654-655. |
[11] | Chen Cen, Cui Beizhou, Gao Yanlin, et al. Analysis on the use of isothiazolinone preservatives in rinse-off cosmetics[J]. Detergent & Cosmetics, 2022, 45 (3) : 26-31, 57. |
[12] | Flavors Fragrances and Cosmetics. Determination of benzyl alcohol as antiseptic in cosmetics by gas chromatography method: GB/T 24800.11—2009[S]. Beijing: Standards Press of China, 2009. |
[13] | Flavors Fragrances and Cosmetics. Determination of 24 preservatives in cosmetics by high performance liquid chromatography method:GB/T 26517—2011[S]. Beijing: Standards Press of China, 2011. |
[14] | Flavors Fragrances and Cosmetics. Cosmetic preservatives-mixture of methylchloroisothiazolinone and methylisothiazolinone with magnesium chloride and magnesium nitrate: GB/T 29666—2013[S]. Beijing: Standards Press of China, 2013. |
[15] | Flavors Fragrances and Cosmetics. Determination of hexamidine, chlorhexidine and their salts as preservatives in cosmetics—High performance liquid chromatography: GB/T 35800—2018[S]. Beijing: Standards Press of China, 2018. |
[16] | Flavors Fragrances and Cosmetics. Determination of seven parabens in cosmetics—high performance liquid chromatography:GB/T 35948—2018[S]. Beijing: Standards Press of China, 2018. |
[17] | Flavors Fragrances and Cosmetics. Determination of permitted preservatives dimethyl oxazolidine, 7-ethylbicyclooxazolidine and 5-bromo-5-nitro-1, 3-dioxane in cosmetics: GB/T 39993—2021[S]. Beijing: Standards Press of China, 2021. |
[18] |
Baranowska I, Wojciechowska I, Solarz N, et al. Determination of preservatives in cosmetics, cleaning agents and pharmaceuticals using fast liquid chromatography[J]. Journal of Chromatographic Science, 2014, 52 (1) : 88-94.
doi: 10.1093/chromsci/bms210 pmid: 23324734 |
[19] | Khan I, Iqbal Z, Khan A, et al. A simple, rapid and sensitive RP-HPLC-UV method for the simultaneous determination of sorafenib & paclitaxel in plasma and pharmaceutical dosage forms: Application to pharmacokinetic study[J]. Journal of Chromatography B, 2016, 1033: 261-270. |
[20] |
Sun W, Hu X, Meng X, et al. Molybdenum disulfide-graphene oxide composites as dispersive solid-phase extraction adsorbents for the enrichment of four paraben preservatives in cosmetics[J]. Microchimica Acta, 2021, 188 (8) : 1-9.
doi: 10.1007/s00604-020-04655-3 |
[21] |
Rajabi M, Sarhadi A, Bazregar M, et al. Rapid derivatization and extraction of paraben preservatives by fast syringe-assisted liquid-liquid microextraction and their determination in cosmetic and aqueous sample solutions by gas chromatography[J]. Analytical Methods, 2017, 9 (41) : 5963-5969.
doi: 10.1039/C7AY01375B |
[22] |
Liu Yunfeng, Zhang Jialing, Nie Xuefei, et al. Simultaneous determination of 11 preservatives in cosmetics and pharmaceuticals by matrix solid-phase dispersion coupled with gas chromatography[J]. Acta Chromatographica, 2020, 32 (3) : 203-209.
doi: 10.1556/1326.2019.00700 |
[23] |
Li Li, Li Shuo, Wang Haiyan, et al. Influence of chromatographic column selection on the determination of 23 preservatives[J]. Chinese Journal of Chromatography, 2022, 40 (2) : 190-197.
doi: 10.3724/SP.J.1123.2021.05006 |
[24] | Zhong Jiqiang, Zheng Rong, Chen Dandan, et al. Detection of 7 kinds of preservatives in cosmetics by gas chromatography with electron capture detector[J]. Chinese Journal of Pharmaceutical Analysis, 2018, 38 (5) : 806-811. |
[25] | Lin Maofa, Huang Yonghui, Hu Zhaoyang, et al. Simultaneous determination of restricted phenolic preservatives in cosmetics by GC[J]. Flavour Fragrance Cosmetics, 2018 (4) : 49-53, 73. |
[26] | Xu Jiaqi, Yang Hongmei, Gong Shengzhao. Simultaneous determination of six kinds of preservatives in cosmetics by HPLC[J]. Flavour Fragrance Cosmetics, 2021 (5) : 51-54. |
[27] | Xing Haiyan, Sun Li, Wu Xu, et al. Simultaneous determination of nine kinds of 4-hydroxybenzoate preservatives in cosmetics by high performance liquid chromatography[J]. Chemical Analysis and Meterage, 2021, 30 (5) : 46-50. |
[28] | Chen Dandan, Ru Ge, Yuan Xiaoqian, et al. Determination of diazolidinyl urea in cosmetics by high performance liquid chromatography[J]. Chemical Analysis and Meterage, 2019, 28 (3) : 57-59, 67. |
[29] | Xu Yong, Zhong Qiang, Zheng Rong. Determination of the contents of seventeen kinds of preservative in cosmetic by GC-MS[J]. Flavour Fragrance Cosmetics, 2020 (6) : 72-79. |
[30] |
Sun Jing, Tan Li, Cao Ling, et al. Determination of 25 preservatives in cosmetics by gas chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, 2019, 37 (3) : 331-339.
doi: 10.3724/SP.J.1123.2018.11007 |
[31] | Zhou Fadong, Zhang Wei, Li Liyuan, et al. Determination of 2, 4, 6-Trichlorophenol, pentachlorophenol in toner and moisturizer by liquid chromatography-tandem mass spectrometey[J]. Journal of the Hebei Academy of Sciences, 2015, 32 (1) : 47-53. |
[32] |
Alvarez-Rivera G, Dagnac T, Lores M, et al. Determination of isothiazolinone preservatives in cosmetics and household products by matrix solid-phase dispersion followed by high-performance liquid chromatography-tandem mass spectrometry[J]. Journal of Chromatography A, 2012, 1270: 41-50.
doi: 10.1016/j.chroma.2012.10.063 pmid: 23182288 |
[33] |
Guerra E, Alvarez-Rivera G, Llompart M, et al. Simultaneous determination of preservatives and synthetic dyes in cosmetics by single-step vortex extraction and clean-up followed by liquid chromatography coupled to tandem mass spectrometry[J]. Talanta, 2018, 188: 251-258.
doi: S0039-9140(18)30546-0 pmid: 30029372 |
[34] | Wang Xiujuan, Guo Wei, Cheng Yunxia, et al. Simultaneous determination of 10 kinds of preservatives in children's cosmetics by QuEChERS-high performance liquid chromatography-tandem mass spectrometry[J]. Journal of Food Safety & Quality, 2021, 12 (19) : 7667-7674. |
[35] | Cheng Jing, Mao Beiping, Zheng Rong, et al. Simultaneous determination of 23 preservatives in 8 different matrixes of cosmetics by HPLC-MS/MS[J]. China Surfactant Detergent & Cosmetics, 2018, 48 (12) : 717-724. |
[36] |
Lamarca R S, Luchiari N C, Bonjorno A F, et al. Determination of formaldehyde in cosmetic products using gas-diffusion microextraction coupled with a smartphone reader[J]. Analytical Methods, 2019, 11 (29) : 3697-3705.
doi: 10.1039/C9AY00720B |
[37] |
Gao Ying, Shi Zeming, Zong Qinxia, et al. Direct determination of mercury in cosmetic samples by isotope dilution inductively coupled plasma mass spectrometry after dissolution with formic acid[J]. Analytica Chimica Acta, 2014, 812: 6-11.
doi: 10.1016/j.aca.2014.01.002 pmid: 24491757 |
[38] | Pan Chen, Wang Meibo, Wu Silin, et al. Determination of five bromine contained preservatives in cosmetics by high performance liquid chromatography-inductively coupled plasma mass spectrometry[J]. Journal of Instrumental Analysis, 2019, 38 (7) : 830-834. |
[39] | Tan Aolei, Ma Xiaoxiao. Rapid analysis of additives in cosmetics using antireflection surfaces laser desorption ionization mass spectrometry[J]. Journal of Instrumental Analysis, 2022, 41 (3) : 381-385. |
[40] | Zhang Shuai, Gao Lidi, Liang Hui, et al. Simultaneous separation and determination of seven preservatives in cosmetics by high performance capillary electrophoresis[J]. Journal of Instrumental Analysis, 2020, 39 (2) : 258-262. |
[41] | Xu Yuan, Ling Bangzan, Yao Dong, et al. Determination of five preservatives in cosmetics by fully automated quantitative micellar electrokinetic capillary chromatography[J]. Journal of Instrumental Analysis, 2015, 34 (6) : 676-680. |
[42] | Ma Teng. Ionic liquid dispersive liquid phase microextraction coupled with capillary electrophoresis for the determination of ultraviolet filters and preservatives in cosmetics[D]. Changchun: Journal of Jilin University, 2016. |
[43] | Sheng Juan, Zhang Haiyan, Chu Chengding, et al. Simultaneous determination of six parabens in cosmetic products by micellar electrokinetic capillary chromatography[J]. Chinese Journal of Analysis Laboratory, 2013, 32 (11) : 88-92. |
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