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日用化学工业（中英文）

日用化学工业（中英文） ›› 2026, Vol. 56 ›› Issue (10): 1371-1379.doi: 10.3969/j.issn.2097-2806.2026.10.010

• 专论与综述 • 上一篇    下一篇

AGEs合成、细胞应答及降解机制研究进展

高媛媛1,赵航晴1,底烨2,陈顾慧2,沈子若2,何聪芬1,董坤1,*()   

  1. 1 北京工商大学 轻工科学与工程学院 北京市植物资源研究开发重点实验室， 北京 102445
    2 资生堂（中国）研究开发中心， 上海 201203
  • 收稿日期:2025-12-11 修回日期:2026-09-10 出版日期:2026-10-22 发布日期:2026-10-30

Research progress on the synthesis, cellular responses, and degradation mechanisms of advanced glycation end products

Yuanyuan Gao1,Hangqing Zhao1,Ye Di2,Guhui Chen2,Ziruo Shen2,Congfen He1,Kun Dong1,*()   

  1. 1 Beijing Key Laboratory of Plants Resource Research and Development, School of Light Industry and Engineering, Beijing Technology and Business University, Beijing 102445, China
    2 Shiseido China Innovation Center, Shanghai 201203, China
  • Received:2025-12-11 Revised:2026-09-10 Online:2026-10-22 Published:2026-10-30
  • Contact: E-mail: dongkun@btbu.edu.cn

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摘要：

明晰晚期糖基化终产物（Advanced glycation endproducts，AGEs）来源和去路，对抗糖化妆品研发十分必要。文章从AGEs产生影响因素、AGEs合成、细胞应答、降解等汇总发现，内、外源性因素通过影响血糖浓度、AGEs降解效率、炎症等影响AGEs合成，合成途径涉及多元醇、糖酵解等传统途径及美拉德反应、丙酮醇途径、葡萄糖自氧化等非传统途径；AGEs引起胶原纤维机械性改变，或通过与RAGE、AGE-Rs家族、NF-κB通路等刺激细胞应答；AGEs降解通过AGE-Rs家族识别或胞吞，基于细胞代谢酶系统降解后，进入血液循环或经尿液排出体外。为有效控制AGEs在皮肤的累积，并针对性开发抗糖化妆品奠定理论基础。

关键词: 非酶糖基化, 影响因素, 合成, 细胞应答, 降解

Abstract:

Clarifying the sources and elimination pathways of advanced glycation end products （AGEs） is of great necessity for the development of anti-glycation cosmetics. This paper summarizes findings from studies on influencing factors of AGE formation, AGE synthesis, cellular responses, and degradation. It reveals that both endogenous and exogenous factors affect AGE synthesis by modulating blood glucose levels, AGE degradation efficiency, and inflammatory responses. The synthetic pathways involve traditional routes such as the polyol and glycolytic pathways, as well as non-traditional mechanisms including the Maillard reaction, acetol pathway, and glucose autoxidation. AGEs induce mechanical alterations in collagen fibers or stimulate cellular responses through interactions with receptors like RAGE, members of the AGE-R family, and the NF-κB signaling pathway. AGE degradation occurs via recognition by AGE-R or endocytosis, followed by breakdown mediated by cellular metabolic enzyme systems, with subsequent elimination through blood circulation or urinary excretion. Consequently, strategies aimed at suppressing AGE accumulation in the skin provide a theoretical foundation for the targeted development of anti-glycation cosmetics.

Key words: non-enzymatic glycation, influencing factors, synthesis, cellular response, degradation

中图分类号: 

  • TQ658