关键词: 网络药理学, 研究进展, 化妆品, 应用展望

Abstract:

The emergence of cyberpharmacology is the result of the current development of artificial intelligence and big data era, which plays a very important role in the treatment of diseases and the development of new drugs in the field of medicine, and is currently mainly used to reveal the mechanism of action of drugs in the body to treat diseases and guide the use of drugs. The mechanism of action on the skin is similar to the action of Chinese medicine on the body in the field of medicine, but there is no research on the application of network pharmacology in the field of cosmetics. In this paper, we review the current development of applied research in cyberpharmacology from the aspects of pharmacology and Chinese medicine research, complex disease discovery, and drug creation, and propose the future application of cyberpharmacology in the selection of cosmetic botanical efficacy ingredients, cosmetic efficacy evaluation, and cosmetic safety evaluation. It is pointed out that skin-related targets, such as sensitive skin-related inflammatory targets: TNF-α, IL-1α, IL-1β, IL-8, TRPV1; whitening-related targets: TYR, TRP-1, TRP-2; acne-related anti-inflammatory and antibacterial targets, etc., can be used to screen herbal ingredients for cosmetic products and guide the development of formulations to achieve precise skin care. Network pharmacology can also be applied to the phyto-effective ingredients in the existing formulations to explore the mechanism of action, efficacy evaluation and safety evaluation. This paper presents insights and operational steps for the application of network pharmacology in the above aspects, with the aim of providing new scientific and technological support for the development of cosmetics.

Key words: network pharmacology, research progress, cosmetic, application prospect