黑素合成相关MITF基因及其表达研究概况

doi:10.13218/j.cnki.csdc.2017.01.010

摘要/Abstract

摘要： 小眼畸形相关转录因子(MITF)是黑素合成过程中最重要的转录因子。介绍了MITF基因及其转录水平的调控;综述了MITF蛋白及其对黑素细胞作用和黑素合成的调控,其主要通过调控酪氨酸酶(TYR)基因家族来控制黑素细胞的生存和分化以及黑素的合成、转运和分布;介绍了MITF在化妆品、医学方面的应用研究现状,并对其在该领域的应用和研究趋势进行了展望。

关键词: 美白, 黑素合成, 小眼畸形相关转录因子, 转录, 调控

Abstract: Microphthalmia-associated transcription factor (MITF) is the most important transcription factor in the melanogenesis process.MITF gene and its regulation of transcription level were presented.MITF protein and its action on melanocyte and regulation of melanogenesis,mainly via regulation of tyrosinase (TYR) gene family to control the survival and differentiation of melonocyte as well as conduction of the melanogenesis,its transportation and distribution were summarized.The application situation and prospect of MITF on cosmetics and medicine development were discussed.

Key words: whitening, melanogenesis, MITF, transcription, regulation

中图分类号:

TQ658.2

杨鹏欣, 刘蕾, 马来记, 何聪芬. 黑素合成相关MITF基因及其表达研究概况[J]. 日用化学工业, 2017, 47(1): 46-51.

YANG Peng-xin, LIU Lei, MA Lai-ji, HE Cong-fen. Situation of research work with respect to melanogenesis-associated MITF gene and its expression[J]. China Surfactant Detergent & Cosmetics, 2017, 47(1): 46-51.

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