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日用化学工业（中英文）

日用化学工业（中英文） ›› 2023, Vol. 53 ›› Issue (6): 665-672.doi: 10.3969/j.issn.2097-2806.2023.06.008

• 开发与应用 • 上一篇    下一篇

人参红景天乳液的制作及其抗氧化、美白作用研究

韩雨迪1,金莉英1,孙熙浛2,林长青3,*(),崔承弼1,2,4,*()   

  1. 1.延边大学 融合学院，吉林 延吉 133002
    2.延边大学 农学院，吉林 延吉 133002
    3.延边大学 医学院，吉林 延吉 133002
    4.延边大学 长白山天然药物研究教育部重点实验室，吉林 延吉 133002
  • 收稿日期:2022-07-14 修回日期:2023-05-30 出版日期:2023-06-22 发布日期:2023-06-25
  • 基金资助:
    吉林省2023年省预算内基本建设资金（创新能力建设）(2023C037-8);延边大学校企合作项目(ydxq202302)

Preparation of a lotion containing Rhodiola rosea and Panax ginseng and its antioxidant and whitening effects

Han Yudi1,Jin Liying1,Sun Xihan2,Lin Changqing3,*(),Cui Chengbi1,2,4,*()   

  1. 1. Convergence College of Yanbian University, Yanji, Jilin 133002, China
    2. Agriculture College of Yanbian University,Yanji, Jilin 133002, China
    3. Medical School of Yanbian University, Yanji, Jilin 133002, China
    4. Key Laboratory of Natural Medicine Research of Changbai Mountain, Ministry of Education, Yanbian University, Yanji, Jilin 133002, China
  • Received:2022-07-14 Revised:2023-05-30 Online:2023-06-22 Published:2023-06-25
  • Contact: *E-mail: lcq0608@163.com （Changqing Lin）; cuichengbi@ybu.edu.cn （Chengbi Cui）

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摘要：

试验确定了红景天提取物与人参提取物的最佳复配比并以其为原料制成人参红景天乳液，采用正交试验确定了其最佳工艺，并采用1，1-二苯基-2-三硝基苯肼（DPPH）、2，2'-联氨-双（3-乙基苯并噻唑啉）二胺盐（ABTS）、3-氧代-2-苯基-4，4，5，5-四甲基咪唑啉-1-氧（PTIO）自由基清除试验及乳液中总黄酮含量的测定、小鼠B16黑色素瘤细胞实验、酪氨酸酶及黑色素抑制实验、黑色素细胞氧化应激相关蛋白表达实验研究其抗氧化和美白作用。结果表明：人参红景天乳液中红景天提取物与人参提取物的体积分数比为5∶3时配方最佳，乳化温度为80 ℃、乳化时间为20 min、乳化速度为4 000 r/min为最佳工艺，此条件下乳液的总黄酮含量为1.84 mg/mL，其对DPPH，ABTS，PTIO自由基的清除率分别为40.17%，48.27%，38.22%，酪氨酸酶抑制率与黑色素抑制率分别为40.49%和35.64%，且在中、高剂量组中氧化应激相关蛋白表达量较高，人参红景天乳液具有良好的抗氧化活性及美白功效。

关键词: 红景天, 人参, 乳液, 抗氧化, 美白

Abstract:

The best mixing ratio of Rhodiola rosea extract and Panax ginseng extract was determined, and this mixture was used as a raw material to prepare a lotion. The process was optimized by orthogonal experiment. The antioxidant and whitening effects of the lotion were studied by DPPH, ABTS, PTIO free radical scavenging tests, measurement of total flavonoid content, mouse B16 melanoma cell test, tyrosinase and melanin inhibition tests, and melanocyte oxidative stress-related protein expression test. The results showed that, when the ratio of Rhodiola rosea extract to Panax ginseng extract in the lotion was 5∶3, the optimal formula was obtained. The optimized conditions were emulsification temperature of 80 ℃, emulsification time of 20 min, and emulsification speed of 4 000 r/min. The total flavonoid content of the lotion thus obtained was 1.84 mg/mL.The scavenging rates for DPPH, ABTS and PTIO free radicals were 40.17%, 48.27% and 38.22%, respectively. The inhibition rates on tyrosinase and melanin were 40.49% and 35.64%, respectively. The expression of oxidative stress-related proteins was high in the middle- and high-dose groups. Therefore, the lotion containing Rhodiola rosea and Panax ginseng had good antioxidant activity and whitening efficacy.

Key words: Rhodiola rosea, Panax ginseng, lotion, anti-oxidant, whitening

中图分类号: 

  • TQ658