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日用化学工业 ›› 2014, Vol. 44 ›› Issue (8): 472-475.doi: 10.13218/j.cnki.csdc.2014.08.105

• 分析与检测 • 上一篇    下一篇

液相色谱-质谱法测定化妆品中10种邻苯二甲酸酯

白亚敏1,2, 杨小珊1,2, 毛庆1,2, 江生1,2, 秦剑1,2   

  1. 1.重庆市食品药品检验所,重庆 401121;
    2.重庆市药物过程与质量控制工程技术研究中心,重庆 401121
  • 收稿日期:2014-02-20 发布日期:2019-04-08
  • 通讯作者: 杨小珊,高级工程师,博士,电话:(023)86072705,E-mail:965241582@qq.com。
  • 作者简介:白亚敏(1977-),女,工程师,硕士,电话:(023)86072760,E-mail:byamin@163.com。
  • 基金资助:
    重庆市科技攻关计划资助项目(cstc2012ggB10001)

Determination of ten kinds of phthalic acid ester in cosmetics by LC-MS

BAI Ya-min1,2, YANG Xiao-shan1,2, MAO Qing1,2, JIANG Sheng1,2, QIN Jian1,2   

  1. 1.Chongqing Institute for Food and Drug Control,Chongqing 401121,China;
    2.Chongqing Engineering Research Center for Pharmaceutical Process and Quality Control,Chongqing 401121,China
  • Received:2014-02-20 Published:2019-04-08

摘要: 采用液相色谱-质谱(LC-MS)法检测化妆品中10种邻苯二甲酸酯类化合物的残留量。化妆品样品溶解后超声振荡提取,采用多反应监测模式进行检测,外标法定量。结果表明,添加浓度为10倍检出限时,邻苯二甲酸酯类化合物的回收率为76.2%~95.2%,相对标准偏差为4.4%~8.9%。可用于化妆品中10种邻苯二甲酸酯类化合物的同时测定。

关键词: 化妆品, 液相色谱-质谱法, 邻苯二甲酸酯类化合物

Abstract: A method was established to determine residual content of phthalic acid esters (PAEs) in cosmetics.Samples were dissolved and then extracted under assistance of ultrasonic wave.Detection was performed using multiple reaction monitoring mode.The quantification was obtained utilizing the external standard method.Recoveries of residual content PAEs,with spike of ten times of the detection limit were 76.2%-95.2%,and the RSDs of the method were 4.4%-8.9%.The method can be applied to determine ten kinds of PAE in cosmetics simultaneously.

Key words: cosmetics, liquid chromatography-mass spectrometry (LC-MS), phthalic acid esters

中图分类号: 

  • TQ658