顶空-气相色谱法测定化妆品中甲基丙烯酸甲酯含量

doi:10.3969/j.issn.1001-1803.2020.08.012

摘要/Abstract

摘要：

建立了化妆品中甲基丙烯酸甲酯的顶空-气相色谱测定方法。样品经丙酮溶解后,采用顶空-气相色谱-氢火焰离子化检测器检测,以外标法定量。方法检出限为6 mg/kg,定量限为20 mg/kg。甲基丙烯酸甲酯在10~500 mg/L范围内线性关系良好,相关系数r为0.999 7,在水基类、粉类、霜乳类、油类化妆品中的平均回收率为98.2%~103.0%,相对标准偏差为2.8%~7.6％。方法前处理简单,灵敏度高,经过8家检测机构的验证,准确可靠,可满足水基类、粉类、霜乳类以及油类化妆品中甲基丙烯酸甲酯的检测要求。

关键词: 化妆品, 甲基丙烯酸甲酯, 顶空-气相色谱

Abstract:

A new method was developed for the determination of methyl methacrylate （MMA） in cosmetics by headspace gas chromatography （HS-GC）. After being dissolved in acetone, the samples were determined by headspace gas chromatography-hydrogen flame ionization detector （HS-GC-FID） and quantified by external standard method. The LOD and LOQ of method were 6 and 20 mg/kg, respectively. There existed a good linearity for the MMA in the mass concentration range of 10~500 mg/L, with the correlation coefficient of 0.999 7. The average recoveries of MMA in the cosmetics （water-based, powder, emulsion, oiliness） were in the ranges of 98.2%~103.0% with their RSDs of 2.8%~7.6％. The optimized method is accurate, rapid and sensitive with simple pretreatment. It has been validated by eight testing institutions , and is suitable for the determination of MMA in cosmetics （water-based, powder, emulsion, oiliness）.

Key words: cosmetics, methyl methacrylate, headspace gas chromatography

中图分类号:

TQ658

郑国灿,陈江,王晶,彭光宇. 顶空-气相色谱法测定化妆品中甲基丙烯酸甲酯含量[J]. 日用化学工业, 2020, 50(8): 576-580.

ZHENG Guo-can,CHEN Jiang,WANG Jing,PENG Guang-yu. Determination of methyl methacrylate in cosmetics by headspace gas chromatography[J]. China Surfactant Detergent & Cosmetics, 2020, 50(8): 576-580.

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基质	添加水平/（mg·kg^-1）	平均回收率/%	RSD/%
	20	99.0	4.4
水基类	40	103.0	5.3
	200	101.9	4.0
	20	99.9	7.6
粉类	40	98.2	6.5
	200	101.3	5.4
	20	100.9	4.0
霜乳类	40	101.6	6.1
	200	101.8	4.9
	20	98.9	5.0
油类	40	99.8	2.8
	200	101.2	3.5

基质	添加水平/（mg·kg^-1）	平均回收率/%	RSD/%
	20	96.72	5.65
水基类	40	93.79	7.18
	200	98.47	4.54
	20	97.91	6.98
粉类	40	95.09	6.02
	200	97.51	5.28
	20	99.17	6.14
霜乳类	40	94.4	6.92
	200	95.77	7.16
	20	94.04	6.28
油类	40	92.84	7.12
	200	97.86	4.89