一种基于胆固醇衍生物的两亲分子的合成及其聚集行为

doi:10.13218/j.cnki.csdc.2016.05.001

日用化学工业 ›› 2016, Vol. 46 ›› Issue (5): 243-246.doi: 10.13218/j.cnki.csdc.2016.05.001

• 基础研究 • 下一篇

一种基于胆固醇衍生物的两亲分子的合成及其聚集行为

郝姗姗,赵莉,徐宝财

北京工商大学食品学院食品添加剂与配料北京高校工程研究中心,北京 100048

出版日期:2016-05-22 发布日期:2016-05-22
通讯作者: 赵莉,副教授,博士,电话:(010)68985382,E-mail:zhaol@btbu.edu.cn。
作者简介:郝姗姗(1992-),女,河北人,硕士研究生,电话:(010)68985382,E-mail:15201518264@163.com。
基金资助:
国家自然科学基金资助项目(21403010);北京市教委科技计划面上项目(KM201510011007);北京市教委科技计划重点资助项目(KZ201510011010)

Synthesis of cholesterol derivative based amphiphilic molecules and their aggregation behavior

HAO Shan-shan,ZHAO Li,XU Bao-cai

School of Food and Chemical Engineering,Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients,Beijing Technology and Business University,Beijing 100048,China

Online:2016-05-22 Published:2016-05-22

摘要/Abstract

摘要： 合成了以胆固醇为疏水基、双甘肽为亲水基的两亲分子N-胆固醇甲酰基双甘肽钾盐(Chol-GG-K)。利用透射电镜(TEM)、激光共聚焦显微镜(CLSM)等手段研究了该分子在水中的聚集行为,发现其在水中形成了多分散的囊泡结构。胆固醇的范德华力形成强疏水作用和聚集能力,亲水基的氢键作用也是产生聚集作用的驱动力。

关键词: 两亲分子, 胆固醇, 聚集行为, 囊泡, 范德华力

Abstract: A new kind of surfactant composed of amphiphilic molecules,potassium salt of N-cholesterol formyl glycylglycine (Chol-GG-K) employing cholesterol as the hydrophobic moiety and glycylglycine as the hydrophilic group,was synthesized and characterized.The aggregation behavior of the product in water was investigated by transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM).Results indicated that poly dispersive vesicles formed in Chol-GG-K aqueous solution.Besides the van der Waals interaction of cholesterol that forms strong hydrophobic effect and aggregation capacity,the hydrogen bonding of the hydrophilic group is also a driving force for the aggregation.

Key words: amphiphilic molecules, cholesterol, aggregation behavior, vesicle, van der Waals interaction

中图分类号:

TQ423

郝姗姗,赵莉,徐宝财. 一种基于胆固醇衍生物的两亲分子的合成及其聚集行为[J]. 日用化学工业, 2016, 46(5): 243-246.

HAO Shan-shan,ZHAO Li,XU Bao-cai. Synthesis of cholesterol derivative based amphiphilic molecules and their aggregation behavior[J]. China Surfactant Detergent & Cosmetics, 2016, 46(5): 243-246.

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一种基于胆固醇衍生物的两亲分子的合成及其聚集行为

Synthesis of cholesterol derivative based amphiphilic molecules and their aggregation behavior

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