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日用化学工业（中英文）

日用化学工业 ›› 2020, Vol. 50 ›› Issue (9): 648-652.doi: 10.3969/j.issn.1001-1803.2020.09.012

• 分析与检测 • 上一篇    

离子色谱法和高效液相色谱法测定化妆品中的丁卡因及其盐类

郭项雨(),赵卫哲,王锋,夏德富,李文涛(),马强()   

  1. 中国检验检疫科学研究院,北京 100176
  • 收稿日期:2020-05-01 修回日期:2020-08-28 出版日期:2020-09-22 发布日期:2020-09-23
  • 通讯作者: 李文涛,马强
  • 作者简介:郭项雨（1986-）,男,助理研究员,硕士,电话：（010）53897459,E-mail：guoxy@caiq.org.cn。
  • 基金资助:
    国家标准化管理委员会计划项目(20173894-T-607)

Determination of tetracaine and its salts in cosmetics by IC and HPLC

GUO Xiang-yu(),ZHAO Wei-zhe,WANG Feng,XIA De-fu,LI Wen-tao(),MA Qiang()   

  1. Chinese Academy of Inspection and Quarantine, Beijing 100176, China
  • Received:2020-05-01 Revised:2020-08-28 Online:2020-09-22 Published:2020-09-23
  • Contact: Wen-tao LI,Qiang MA

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摘要：

建立了化妆品中丁卡因及其盐类的离子色谱和高效液相色谱分析方法,并对两种检测方法进行了比对分析。采用离子色谱法,丁卡因及其盐类的检出限和定量限分别为10和25 mg/kg,方法平均回收率为87.6%~102.7%,相对标准偏差为1.1%~4.7%。采用高效液相色谱法,丁卡因及其盐类的检出限和定量限分别为2和5 mg/kg,方法平均回收率为89.5%~105.6%,相对标准偏差为1.4%~5.8%。对于疑似阳性样品,进一步采用高效液相色谱-串联质谱法进行确证分析。经比较,两种方法检测化妆品中的丁卡因及其盐类的色谱保留时间均在5 min以内,方法学数据均满足分析要求。

关键词: 化妆品, 丁卡因及其盐类, 离子色谱法, 高效液相色谱法, 质谱确证

Abstract:

Two analytical methods were developed for the determination of tetracaine and its salts in cosmetics based on ion chromatography （IC） and high-performance liquid chromatography （HPLC）. The two detection methods were compared. The limit of detection （LOD） and quantitation （LOQ） of tetracaine were 10 and 25 mg/kg for the IC method. The average recoveries ranged from 87.6% to 102.7% with the relative standard deviations （RSDs） of 1.1%-4.7%. The LOD and LOQ were 2 and 5 mg/kg for the HPLC method. The average recoveries ranged from 89.5% to 105.6% with the RSDs of 1.4%-5.8%. The suspected positive samples were subjected to further verification by high-performance liquid chromatography-tandem mass spectrometry （HPLC-MS/MS）. The chromatographic retention time of tetracaine and its salts was both within 5 min and the experimental data of the two methods met the performance requirements.

Key words: cosmetics, tetracaine and its salt, ion chromatography, high-performance liquid chromatography, mass spectrometric verification

中图分类号: 

  • TQ658