[1] Qu X T,Cheng S J,Qin Y,et al.Adverse outcome pathways guide and toxicity test applications [J].China Surfatant Detergent & Cosmetics,2016,46(8):473-478. [2] OECD.The adverse outcome pathway for skin sensitization initiated by covalent binding to proteins.Part 2:Use of the AOP to develop chemical categories and integrated assessment and testing approaches.series on testing and assessment No.168 [S].Paris:OECD,2012. [3] Van Meer P J,Graham M L,Schuurman H J.The safety,efficacy and regulatory triangle in drug development:Impact for animal models and the use of animals [J].European Journal of Pharmacology,2015,759:3-13. [4] Patlewicz G,Kuseva C,Kesova A,et al.Towards AOP application-implementation of an integrated approach to testing and assessment (IATA) into a pipeline tool for skin sensitization [J].Regulatory Toxicology & Pharmacology,2014,69(3):529-45. [5] Nukada Y,Ito Y,Miyazawa M,et al.The relationship between CD86 and CD54 protein expression and cytotoxicity following stimulation with contact allergen in THP-1 cells [J].Journal of Toxicological Sciences,2011,36(3):313-324. [6] Facy V,Flouret V,Régnier M,et al.Reactivity of Langerhans cells in human reconstructed epidermis to known allergens and UV radiation [J].Toxicology in Vitro,2005,19(6):787-795. [7] Hennen J,Blömeke B.Keratinocytes improve prediction of sensitization potential and potency of chemicals with THP-1 cells [J].Altex,2016,34(2):279-288. [8] Cheng S J,Qin Y,Bu L.Establish verification criteria for in vitro reconstructive human skin model stimulation test [J].Laboratory Animal and Comparative Medicine,2012,23(3):243-246. [9] Coquette A,Berna N,Vandenbosch A,et al.Analysis of interleukin-1alpha (IL-1alpha) and interleukin-8 (IL-8) expression and release in in vitro reconstructed human epidermis for the prediction of in vivo skin irritation and/or sensitization [J].Toxicology in Vitro,2003,17(3):311-321. [10] Braun S,Hanselmann C,Gassmann M G,et al.Nrf2 transcription Factor,a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound [J].Mol Cell Biol,2002,8(22):5492-5505. [11] Natsch A.The Nrf2-Keap1-ARE toxicity pathway as a cellular sensor for skin sensitizers--functional relevance and a hypothesis on innate reactions to skin sensitizers [J].Toxicological Sciences,2010,113(2):284-292. [12] Van Wolfswinkel J C.Assessment of potency of allergenic activity of low molecular weight compounds based on IL-1alpha and IL-18 production by a murine and human keratinocyte cell line [J].Toxicology,2005,210(2/3):95-109. [13] Parise C B,Sá-Rocha V M,De Moraes J Z.Skin sensitizer identification by IL-8 secretion and CD86 expression on THP-1 cells [J].Toxicology in Vitro,2015,30(1):318-324. [14] Jung Y S,Kato R,Tsuchiya T.Biodegradable polymers induce CD54 on THP-1 cells in skin sensitization test [J].International Journal of Biomaterials,2011,2011(P1):424571. [15] OECD.in Vitro skin sensitization [S].Paris:OECD,2017. [16] Jw V D V,Pronk T E,Van L H,et al.Applicability of a keratinocyte gene signature to predict skin sensitizing potential [J].Toxicology in Vitro,2013,27(1):314-322. [17] Ellis G,Natsch A,Emter R.Prediction of skin sensitizers by combining a high-throughput keratinocyte-based reporter gene assay with peptide reactivity measurements [J].Toxicology Letters,2010,196(S1):30-S131. [18] Teunis M,Corsini E,Smits M,et al.Transfer of a two-tiered keratinocyte assay:IL-18 production by NCTC2544 to determine the skin sensitizing capacity and epidermal equivalent assay to determine sensitizer potency [J].Toxicology in Vitro,2013,27(3):1135-1150. |