一种美白霜的研制及其美白功效评价

doi:10.13218/j.cnki.csdc.2017.09.007

摘要/Abstract

摘要： 以传明酸、烟酰胺、4-甲氧基水杨酸钾和光果甘草根提取物为主要美白活性成分制备了一种美白霜。该美白霜分布均匀、无颗粒感、细腻柔滑、稠度适宜,稳定性良好;采用3D黑素皮肤模型体外测试和人体试验的方法对其进行了美白功效评价。3D黑素皮肤模型体外测试结果表明,该美白霜对黑色素的合成或转运有显著的抑制作用,具有优异的体外美白功效;人体试验结果表明,使用该美白霜4周后,受试者皮肤黑色素含量(MI值)明显降低,肌肤白度(L^*值)和明亮度(ITA°值)增加,说明其具有良好的美白效果。

关键词: 美白化妆品, 3D黑素皮肤模型, 体外测试, 人体试验

Abstract: Tranexamic acid,nicotinamide,potassium 4-methoxysalicylate and Glycyrrhiza glabra (licorice) root extract were used as the main whitening active ingredients to prepare a human-skin whitening cream.The prepared human-skin whitening cream is uniform,no granulous feeling,delicate and smooth,with good consistency and stability.The whitening effect was evaluated by 3D melanin skin model in vitro test and volunteer's human-skin test.The results of 3D melanin skin model in vitro test show that the prepared human-skin whitening cream displays significant inhibitory effect on the synthesis or transfer of melanin,which indicates that it has excellent whitening effect in vitro.Human-skin test results show that the skin melanin content (MI value) of the volunteer's skin is significantly reduced,and their skin whiteness (L^* value) and brightness (ITA° value) are increased after using the prepared human-skin whitening cream for 4 weeks,indicating that the prepared human-skin whitening cream displays a good effect.

Key words: whitening cosmetic, 3D melanin skin model, in vitro test, human-skin test

中图分类号:

TQ658.2

万禁禁, 刘瑞学, 冷群英, 陈效芳. 一种美白霜的研制及其美白功效评价[J]. 日用化学工业, 2017, 47(9): 512-516.

WAN Jin-jin, LIU Rui-xue, LENG Qun-ying, CHEN Xiao-fang. Preparation and efficacy evaluation of a human-skin whitening cream[J]. China Surfactant Detergent & Cosmetics, 2017, 47(9): 512-516.

参考文献

[1]Costin G E,Hearing V J.Human skin pigmentation:melanocytes modulate skin color in response to stress [J].The FASEB Journal,2007,21(4):976-994.
[2]Schiaffino M V.Signaling pathways in melanosome biogenesis and pathology [J].The International Journal of Biochemistry & Cell Biology,2010,42(7):1094-1104.
[3]Cardinali G,Ceccarelli S,Kovacs D,et al.Keratinocyte growth factor promotes melanosome transfer to keratinocytes [J].The Journal of Investigative Dermatology,2005,125(6):1190-1199.
[4]An S M,Kim H J,Kim J E,et al.Flavonoids,taxifolin and luteolin attenuate cellular melanogenesis despite increasing tyrosinase protein levels [J].Phytotherapy Research,2008,22(9):1200-1207.
[5]Kim Y J,Uyama H.Tyrosinase inhibitors from natural and synthetic sources:Structure,inhibition mechanism and perspective for the future [J].Cellular and Molecular Life Sciences,2005,62(15):1707-1723.
[6]Hakozaki T,Minwalla L,Zhuang J,et al.The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer [J].British Journal of Dermatology,2002,147(1):20-31.
[7]孙蓓,李潇,卢永波.影响皮肤黑素沉着的美白制剂及其作用机制研究进展[J].中国美容医学,2015,24(22):82-85.
[8]藤原留美子,佐藤洁.美白有效成分 —— 4-甲氧基水杨酸钾(4MSK)的功效[C]//第八届中国化妆品学术研讨会论文集.北京:中国香料香精化妆品工业协会,2010.
[9]王瑞雪,赵珍,钟雁,等.几种常用美白剂协同作用研究[J].日用化学工业,2014,44(10):572-576.
[10]杨建华,孟新源,胡君萍.苁蓉美白防晒霜的制备及其质量评价[J].华西药学杂志,2011,26(3):271-273.
[11]舒鹏,孔胜仲,龚盛昭.一种美白乳液的制备与稳定性研究[J].日用化学工业,2014,44(11):620-623.
[12]中华人民共和国卫生部.化妆品接触性皮炎诊断标准及处理原则:GB 171492 [S].北京:中国标准出版社,1998.
[13]李玲,苏瑾.采用Lab色度系统评价某种美白化妆品的美白功效[J].环境与职业医学,2003,20(1):28-30.
[14]王楠,吴金昊,李昂,等.松茸化妆品的美白功效评价[J].日用化学工业,2016,46(5):279-283.
[15]Weatherall I L,Coombs B D.Skin color measurements in terms of CIELAB color space values [J].Journal of Investigative Dermatology,1992,99(4):468-473.
[16]Mayer J A,Sallis J F,Eckhardt L,et al.Assessing children’s ultraviolet radiation exposure:the use of parental recall via telephone interviews [J].American Journal of Public Health,1997,87(6):1046-1049.
[17]Rubegni P,Cevenini G,Flori M L,et al.Relationship between skin color and sun exposure history:a statistical classification approach [J].Photochemistry and Photobiology,1997,65(2):347-351.
[18]Wee L K S,Chong T K,Quee D.Assessment of skin types,skin colours and cutaneous responses to ultraviolet radiation in an Asian population [J].Photodermatology Photoimmunology & Photomedicine,1997,13(5/6):169-172.
[19]Yoshimura K,Harii K,Masuda Y,et al.Usefulness of a narrow-band reflectance spectrophotometer in evaluating effects of depigmenting treatment [J].Aesthetic Plastic Surgery,2001,25(2):129-133.
[20]赵小敏,赵云珊,瞿欣.图像分析法在化妆品功效评价中的应用[J].日用化学品科学,2016,39(1):29-33.