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日用化学工业（中英文）

日用化学工业 ›› 2016, Vol. 46 ›› Issue (5): 289-291.doi: 10.13218/j.cnki.csdc.2016.05.010

• 开发与应用 • 上一篇    下一篇

物对人皮肤成纤维细胞线粒体膜电位的影响

邓小锋1,孟宏1,李丽1,时宇静2   

  1. 1.北京工商大学,北京 100048;
    2.中国中医科学院 中药研究所,北京 100700
  • 出版日期:2016-05-22 发布日期:2016-05-22
  • 通讯作者: 孟 宏,教授,博士,电话:13691589617,E-mail:menghong2000@163.com。
  • 作者简介:邓小锋(1989-),男,湖南人,硕士研究生,电话:15701577393,E-mail:18774875060@163.com。
  • 基金资助:
    北京市优秀人才培养资助D类(2014000020124G034);北京工商大学化妆品协同创新中心资助项目(19005428069/007);2015年研究生科研能力提升计划项目资助

Effect of blended herb extract on mitochondrial membrane potential of fibroblast

DENG Xiao-feng1,MENG Hong1,LI Li1,SHI Yu-jing2   

  1. 1.Beijing Technology and Business University,Beijing 100048,China;
    2.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China
  • Online:2016-05-22 Published:2016-05-22

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摘要： 线粒体膜电位能一定程度反映人皮肤成纤维细胞凋亡状态。实验结果显示,相比于正常组,H2O2组能降低人皮肤成纤维细胞线粒体膜电位(P＜0.01);与模型组比较,75,150和300 mg/L复合中药提取物组均显著提高了人皮肤成纤维细胞线粒体膜电位(P＜0.01),且呈现剂量依赖性。结果表明,复合中药提取物预防性给药有效,能防止H2O2造成的人皮肤成纤维细胞膜电位的下降并延缓皮肤衰老,有望作为较佳延缓皮肤衰老化妆品添加剂。

关键词: 化妆品添加剂, 复合中药提取物, 线粒体膜电位

Abstract: Apoptosis state of fibroblast of adult skin can be reflected by mitochondrial membrane potential to a certain extent.Experimental results showed that,as comparing with result obtained in the normal control group,that in the hydrogen peroxide group shows reduction of the skin fibroblast mitochondrial membrane potential (P<0.01);while in the model groups with additive composed of extract of blended herb with separate dosages of 75,150 and 300 mg/L,their mitochondrial membrane potential of skin fibroblast are significantly increased (P<0.01),and shows a dose-dependent manner.Such experimental result indicated that the blended herb extract is effective for prevention of mitochondrial membrane potential decreasing caused by hydrogen peroxide and can be used for delaying of skin senility as a prophylactic measure.Hopefully,the blended herb extract may be used as an additive in cosmetics.

Key words: cosmetic additives, blended herb extract, mitochondrial membrane potential

中图分类号: 

  • TQ658