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日用化学工业（中英文）

日用化学工业 ›› 2019, Vol. 49 ›› Issue (10): 656-660.doi: 10.3969/j.issn.1001-1803.2019.10.005

• 开发与应用 • 上一篇    下一篇

蚌肉多糖提取物抗UVB致人真皮成纤维细胞损伤的研究

陈心馨,罗安玲,李佳洛,郑有丽,丛峰松()   

  1. 上海交通大学 生命科学技术学院,上海 200240
  • 收稿日期:2019-01-14 修回日期:2019-09-18 出版日期:2019-10-22 发布日期:2019-10-24
  • 通讯作者: 丛峰松
  • 作者简介:陈心馨（1994-）,女,重庆人,硕士研究生,E-mail： carolcxx@163.com。

Study on the anti- UVB-induced photoaging and damage of human dermal fibroblasts by polysacchride extract from Hyriopsis cumingii

CHEN Xin-xin,LUO An-ling,LI Jia-luo,ZHENG You-li,CONG Feng-song()   

  1. School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
  • Received:2019-01-14 Revised:2019-09-18 Online:2019-10-22 Published:2019-10-24
  • Contact: Feng-song CONG

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摘要：

利用人真皮成纤维细胞（HDF-a）和中波紫外线（306 nm）建立皮肤光损伤模型,以该模型考察蚌肉多糖提取物（HCP）抵御光损伤的能力,分别对其抑制氧化损伤和炎症损伤的功效进行评价。结果显示：质量浓度为0.1,1和10 g/L的HCP能显著提高光损伤HDF-a的存活率,最高可达86.63%;在抑制氧化损伤方面,HCP能有效提高细胞内SOD活性和GSH含量并降低MDA含量,增强细胞清除自由基的能力;在舒缓炎症方面,HCP能阻断NF-κB信号通路,从而抑制IL-6等炎症因子的释放。

关键词: 化妆品添加剂, 多糖提取物, 三角帆蚌, 光老化, 中波紫外线

Abstract:

Human dermal fibroblasts（HDF-a）and UVB（306 nm）were used to construct a skin photoaging model. The anti-photoaging ability of polysacchride extract from Hyriopsis cumingii（HCP）was investigated by using this model, and its effects on inhibiting oxidative damage and inflammation injury were evaluated respectively. Results show that HCP with mass concentration of 0.1,1 and 10 g/L can significantly improve the survival rate of photoaging and damage HDF-a , up to 86.63%. In terms of inhibiting oxidative damage, the extract can effectively increase intracellular SOD activity and GSH content and reduce MDA content, and enhance the ability of cells to scavenge free radicals. In terms of alleviating inflammation, the extract can block the NF-κB signaling pathway and inhibit the release of inflammatory factors such as IL-6.

Key words: cosmetic additive, polysaccharide extract, Hyriopsis cumingii, photoaging, UVB

中图分类号: 

  • TQ658