响应面法优化海藻酸钠微球包封L-抗坏血酸的制备工艺

doi:10.13218/j.cnki.csdc.2014.08.099

摘要/Abstract

摘要： 用内源乳化凝胶法制备包封L-抗坏血酸(V_C)的海藻酸钠(SA)微球。以包封率和粒径为指标,采用单因素及响应面实验相结合的方法,确定了SA微球包封V_C的较佳制备条件:Span 80质量分数为2%,水相体积分数为30%,转速为400 r·min^-1,SA质量浓度为18.80 g·L^-1,n(冰醋酸)/n(CaCO₃)=3.29,m(Ca)/m(SA)=0.071 6,在此条件下,制备的SA微球包封率为63.83%。为进一步提高包封率,在较佳制备条件下,用SA/羧甲基壳聚糖(NOCC)作为壁材制备SA/NOCC微球,其包封率为77.08%。扫描电镜显示SA/NOCC微球表面气孔明显少于SA微球。

关键词: 化妆品添加剂, L-抗坏血酸, 海藻酸钠, 羧甲基壳聚糖, 包封率, 响应面法

Abstract: Sodium alginate (SA) microspheres that are used for L-ascorbic acid encapsulation were prepared by emulsification/internal gelation method.The optimized preparation conditions were studied by combination of single factor experiment and response surface method with encapsulation extent (EE) and particle sizes as indices and the conditions were identified as:dosage of Span 80,2% (mass of the oil phase material);volume fraction of water,30%;stirring speed,400 r·min^-1;mass concentration of SA,18.80 g·L^-1;mole ratio,n(acetic acid)/n(CaCO₃)=3.29;mass ratio,m(Ca)/m(SA)=0.071 6.Under these conditions,the EE of SA microspheres achieves 63.83%.To improve the EE further,microspheres were prepared using SA/N,O-carboxymethyl chitosan (NOCC) as wall materials under the optimized preparation conditions.The EE of SA/NOCC microspheres achieves 77.08%.The scanning electron microscope revealed that microspheres prepared with SA/NOCC have obviously less pores on the surface than that prepared with SA.

Key words: additive of cosmetics, L-ascorbic acid, sodium alginate, N,O-carboxymethyl chitosan, encapsulation extent, response surface method

中图分类号:

TQ658

王婷婷, 曹光群, 董伟. 响应面法优化海藻酸钠微球包封L-抗坏血酸的制备工艺[J]. 日用化学工业, 2014, 44(8): 443-447.

WANG Ting-ting, CAO Guang-qun, DONG Wei. Optimization of the process for preparation of sodium alginate microspheres encapsulating L-ascorbic acid by response surface method[J]. China Surfactant Detergent & Cosmetics, 2014, 44(8): 443-447.

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