烷基磷酸酯与共轭亚油酸形成杂化囊泡的研究

doi:10.13218/j.cnki.csdc.2017.05.001

摘要/Abstract

摘要： 脂肪酸囊泡(FAV)的中空壳核结构能够包埋活性分子。为改善FAV仅在其pK_a附近形成的缺陷,以拓宽FAV的应用范围,将安全性和温和性阴离子表面活性剂烷基磷酸酯钾盐(MAPK)添加到共轭亚油酸中,通过动态激光光散射(DLS)和透射电子显微镜(TEM)研究了囊泡化的pH窗口,发现9% MAPK存在时就可以在中性至酸性环境中形成杂化FAV,不明显改变原有FAV的形貌及粒径,且随着MAPK添加量的增大,杂化FAV的pH窗口有逐渐拓宽的趋势。这一结果显示了杂化FAV在化妆品和个人卫生护理用品等领域的应用前景。

关键词: 烷基磷酸酯钾盐, 脂肪酸囊泡, 化妆品, 个人卫生护理用品

Abstract: Fatty acid vesicles (FAVs) with a hollow core-shell structure can entrap reactive molecules.In order to improve the defect that FAVs can form near its pK_a only so as to enlarge their application field,mild anionic surfactant potassium alkyl phosphate (MAPK) was added to conjugated linoleic acid (CLA).The pH window for vesicles formation was characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM).It was found that hybrid FAVs can be formed at neutral to acidic environment by blending CLA with 9% MAPK without significant change of morphology and particle size of the original FAVs,and the pH window of the hybrid FAVs has a tendency to gradually broaden along with increasing of the dosage of MAPK.The result shows the potential application of FAVs in fields of cosmetics and personal health care products.

Key words: potassium alkyl phosphate, fatty acid vesicles, cosmetics, personal health care products

中图分类号:

TQ423

梁潇丹, 程若辉, 方云, 樊晔, 张豪杰, 何怡静. 烷基磷酸酯与共轭亚油酸形成杂化囊泡的研究[J]. 日用化学工业, 2017, 47(5): 241-245.

LIANG Xiao-dan, CHENG Ruo-hui, FANG Yun, FAN Ye, ZHANG Hao-jie, HE Yi-jing. Study on formation of hybrid vesicles with alkyl phosphate and conjugated linoleic acid[J]. China Surfactant Detergent & Cosmetics, 2017, 47(5): 241-245.

参考文献

[1] Meraz-Torres L,Hernandez-Sanchez H.Conjugated linoleic acid in dairy products:a review [J].American Journal of Food Technology,2012,7(4):176-179.
[2] Singh V,Sachan N.Nutraceutical properties of milk and milk products:a review [J].American Journal of Food Technology,2011,6(10):864-869.
[3] Nugteren D,Christ-Hazelhof E,Van der Beek A,et al.Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat [J].Biochimica et Biophysica Acta (BBA)-Lipids and Lipid Meta-bolism,1985,834(3):429-436.
[4] Oraldi M,Maggiora M,Paiuzzi E,et al.CLA reduces inflammatory mediators from A427 human lung cancer cells and A427 conditioned medium promotes differentiation of C2C12 murine muscle cells [J].Lipids,2013,48(1):29-38.
[5] Schmid A,Collomb M,Sieber R,et al.Conjugated linoleic acid in meat and meat products:a review [J].Meat Science,2006,73(1):29-41.
[6] Zened A,Enjalbert F,Nicot M C,et al.Starch plus sunflower oil addition to the diet of dry dairy cows results in a trans-11 to trans-10 shift of biohydrogenation [J].Journal of Dairy Science,2013,96(1):451-459.
[7] Gebicki J,Hicks M.Ufasomes are stable particles surrounded by unsaturated fatty acid membranes [J].Nature,1973,243(5404):232-234.
[8] Morigaki K,Walde P.Fatty acid vesicles [J].Current Opinion in Colloid and Interface Science,2007,12(2):75-80.
[9] Patel D,Jani R,Patel C.Ufasomes:a vesicular drug delivery [J].Systematic Reviews in Pharmacy,2011,2(2):72-78.
[10] McClements D J.Encapsulation,protection,and release of hydrophilic active components:potential and limitations of colloidal delivery systems [J].Adv Colloid Interface Sci,2015,219:27-53.
[11] McCrorie T A,Keaveney E M,Wallace J M W,et al.Human health effects of conjugated linoleic acid from milk and supplements [J].Nutrition Research Reviews,2011,24(2):206-227.
[12] 樊晔,方云,高迪.pH非敏感型自交联共轭亚油酸囊泡的构建和表征[J].高等学校化学学报,2014,35(8):1746-1752.
[13] Fan Y,Fang Y,Ma L.The self-crosslinked ufasome of conjugated linoleic acid:investigation of morphology,bilayer membrane and stability [J].Colloids and Surfaces B:Biointerfaces,2014,123:8-14.
[14] Fan Y,Fang Y,Ma L,et al.Investigation of micellization and vesiculation of conjugated linoleic acid by means of self-assembling and self-crosslinking [J].Journal of Surfactants and Detergents,2015,18(1):179-188.
[15] 马洁,樊晔,方云.利用烷基糖苷迁移和扩张共轭亚油酸囊泡pH窗口[J].物理化学学报,2015,31(7):1359-1364.
[16] 戴基宁,樊晔,方云.自交联共轭亚油酸囊泡的温敏膨胀行为[J].高等学校化学学报,2015,36(6):1140-1145.
[17] 胡静,王宇轩.洗涤剂用香精微胶囊的制备及其性能研究[J].中国洗涤用品工业,2016(8):42-47.
[18] 马琳,樊晔,方云.碱法异构化亚油酸甲酯制备共轭亚油酸[J]. 精
细化工,2014,31(5):612-616.
[19] Lee J H,Danino D,Raghavan S R.Polymerizable vesicles based on a single-tailed fatty acid surfactant:a simple route to robust nanocontainers [J].Langmuir,2009,25(3):1566-1571.
[20] Rogerson M L,Robinson B H,Bucak S,et al.Kinetic studies of the interaction of fatty acids with phosphatidylcholine vesicles (liposomes) [J].Colloids and Surfaces B:Biointerfaces,2006,48(1):24-34.
[21] Apel C L,Deamer D W,Mautner M N.Self-assembled vesicles of monocarboxylic acids and alcohols:conditions for stability and for the encapsulation of biopolymers [J].Biochimica Et Biophysica Acta-Biomembranes,2002,1559(1):1-9.
[22] Rendon A,Gil Carton D,Sot J,et al.Model systems of precursor cellular membranes:long-chain alcohols stabilize spontaneously formed oleic acid vesicles [J].Biophysical Journal,2012,102(2):278-286.
[23] Zhou C,Cheng X,Zhao O,et al.The evolution of self-assemblies in the mixed system of oleic acid-diethylenetriamine based on the transformation of electrostatic interactions and hydrogen bonds [J].Soft Matter,2014,10(40):8023-8030.
[24] Namani T,Walde P.From decanoate micelles to decanoic acid/dodecylbenzenesulfonate vesicles [J].Langmuir,2005,21(14):6210-6219.
[25] Kopetzki D,Michina Y,Gustavsson T,et al.Fatty acid-cationic surfactant vesicles:counter-ion self-encapsulation [J].Soft Matter,2009,5(21):4212-4218.