PR-CS/γ-PGA纳米胶囊的制备和表征

doi:10.3969/j.issn.1001-1803.2022.07.004

摘要/Abstract

摘要：

以壳聚糖（CS）和聚谷氨酸（γ-PGA）为壁材,采用离子凝胶法制备包覆苯乙基间苯二酚（PR）壳聚糖/聚谷氨酸（PR-CS/γ-PGA）纳米胶囊,提高PR的稳定性。研究了γ-PGA质量浓度、CS溶液pH以及PR质量浓度对包覆PR-CS/γ-PGA纳米胶囊粒径大小、Zeta电位和包覆率的影响。研究结果表明,体系中CS质量浓度为1.33 mg/mL时,制备PR-CS/γ-PGA的最佳条件：CS溶液pH为4.5,γ-PGA质量浓度为0.27 mg/mL,PR质量浓度为0.4 mg/mL,反应时磁力搅拌速度为400 r/min,γ-PGA滴加速度为0.5 mL/min,反应时间为1 h。通过对PR-CS/γ-PGA纳米胶囊进行系统表征：TEM扫描表明,PR-CS/γ-PGA纳米胶囊呈球形。FT-IR分析表明,CS与γ-PGA之间发生静电相互作用形成CS/γ-PGA纳米胶囊,且PR-CS/γ-PGA纳米胶囊中含有PR。TGA曲线表明,CS/γ-PGA纳米胶囊可以提高PR的热稳定性,PR-CS/γ-PGA纳米胶囊成功包覆了PR。

关键词: 壳聚糖, 聚谷氨酸, 苯乙基间苯二酚, 离子凝胶法, 纳米胶囊

Abstract:

Encapsulated phenylethyl resorcinol chitosan/polyglutamic acid （PR-CS/γ-PGA） nanocapsules were prepared by ionic gelation method with chitosan （CS） and polyglutamic acid （γ-PGA） as wall materials. The effects of the mass concentration of γ-PGA, the pH of the CS solution and the mass concentration of PR on the particle size, Zeta potential and encapsulation rate of PR-CS/γ-PGA nanocapsules were studied. The results showed that, with the increase of γ-PGA concentration, the particle size of the suspension of PR-CS/γ-PGA nanocapsules was decreased, and the Zeta potential was also decreased. The encapsulation rate of PR-CS/γ-PGA nanocapsules was first decreased and then increased （the encapsulation rate was the largest when the mass concentration of γ-PGA was 0.27 mg/mL）, and if the mass concentration of γ-PGA was further increased, the encapsulation rate was not significantly changed. With the increase of PR mass concentration, the particle size of the suspension of PR-CS/γ-PGA nanocapsules was increased and the Zeta potential was decreased. The encapsulation rate of PR-CS/γ-PGA nanocapsules was reduced. As the pH of the CS solution was increased, the particle size of the suspension of PR-CS/γ-PGA nanocapsules was first decreased and then increased （the particle size was the smallest when pH=4.5）, and the Zeta potential was decreased. The encapsulation rate of PR-CS/γ-PGA nanocapsules was not significantly changed. When the CS concentration in the system was 1.33 mg/mL, the optimized conditions for preparing PR-CS/γ-PGA nanocapsules were as follows: the pH of CS solution was 4.5, the mass concentration of γ-PGA was 0.27 mg/mL, the mass concentration of PR was 0.4 mg/mL, the magnetic stirring speed was 400 r/min during the reaction, the speed of adding γ-PGA was 0.5 mL/min, and the reaction time was 1 h. Systematic characterization of the PR-CS/γ-PGA nanocapsules was made. TEM results showed that the PR-CS/γ-PGA nanocapsules were spherical. FT-IR analysis showed that the electrostatic interaction between CS and γ-PGA formed CS/γ-PGA nanocapsules, and the PR-CS/γ-PGA nanocapsules contained PR. The TGA curve showed that CS/γ-PGA nanocapsules could improve the thermal stability of PR, and PR-CS/γ-PGA nanocapsules successfully encapsulated PR.

Key words: chitosan, polyglutamic acid, phenethyl resorcinol, ionic gelation method, nanocapsule

中图分类号:

TQ658

张婉萍,吴凯翔,蒋汶,张冬梅. PR-CS/γ-PGA纳米胶囊的制备和表征[J]. 日用化学工业, 2022, 52(7): 710-716.

Zhang Wanping,Wu Kaixiang,Jiang Wen,Zhang Dongmei. Preparation and characterization of PR-CS/γ-PGA nanocapsules[J]. China Surfactant Detergent & Cosmetics, 2022, 52(7): 710-716.

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