欢迎访问《日用化学工业（中英文）》，今天是
日用化学工业（中英文）

日用化学工业 ›› 2018, Vol. 48 ›› Issue (8): 466-471.doi: 10.13218/j.cnki.csdc.2018.08.009

• 分析与检测 • 上一篇    下一篇

高效液相色谱法测定化妆品中苯扎氯铵含量的不确定度评定

王涛1,李卓1,贾寒冰1,孙晓1,田仁芳2,荀英3   

  1. 1.西安市食品药品检验所,陕西 西安 710054;
    2.西安怡康医药连锁有限责任公司,陕西 西安 710054;
    3.渭南市中医医院,陕西 渭南 714000
  • 出版日期:2018-08-22 发布日期:2019-03-22
  • 通讯作者: 荀英,主管中药师,本科,电话:18709257095,E-mail:125296860@qq.com。
  • 作者简介:王涛(1983-),男,陕西人,主管药师,博士,电话:13310900720,E-mail:wto_followme@126.com。

Evaluation of uncertainty in the determination of benzalkonium chloride in cosmetics by HPLC

WANG Tao1,LI Zhuo1,JIA Han-bing1,SUN Xiao1,TIAN Ren-fang2,XUN Ying3   

  1. 1.Xi'an Institute for Food and Drug Control,Xi'an,Shaanxi 710054,China;
    2.Xi'an Yikang Pharmaceutical Chains Co.,Ltd., Xi'an,Shaanxi 710054,China;
    3.Weinan Hospital of Traditional Chinese Medicine,Weinan,Shaanxi 714000,China
  • Online:2018-08-22 Published:2019-03-22

PDF (PC)

287

赞

摘要： 对《化妆品安全技术规范》(2015年版)中高效液相色谱法测定苯扎氯铵3种物质(即十二烷基二甲基苄基氯化铵(C12)、十四烷基二甲基苄基氯化铵(C14)和十六烷基二甲基苄基氯化铵(C16))含量进行了不确定度评定,建立了数学模型,考察了不确定度的来源并给出了量化结果,计算出合成标准不确定度和扩展不确定度。结果表明,当取置信概率为95%,包含因子k=2,被测化妆品中苯扎氯铵C12,C14和C16含量分别为0.045%,0.048%和0.010%时,其标准扩展不确定度分别为0.027%,0.029%和0.006%。指出了测量不确定度的主要来源,并提出了改进方法。

关键词: 化妆品, 苯扎氯铵, 高效液相色谱法, 不确定度

Abstract: Uncertainties from the determination procedure of three substances of benzalkonium chloride (dodecyldimethylbenzylammonium chloride (C12),tetradecyldimethylbenzylammonium chloride (C14) and hexadecyldimethylbenzylammonium chloride (C16) in Safety and Technical Standards for Cosmetics (2015 Edition) by high performance liquid chromatography (HPLC) were assessed.The mathematical model was established,and the source of uncertainty was investigated and quantified.The combined standard uncertainty and expanded uncertainty were calculated.The results show that the expanded uncertainties are 0.027%,0.029% and 0.006% (95% confidence level,k=2) when the mass fraction of benzalkonium chloride (C12,C14 and C16 ) in cosmetics are 0.045%,0.048% and 0.010%,respectively.The main sources of the uncertainty are analyzed,and improved method is introduced.

Key words: cosmetics, benzalkonium chloride, high performance liquid chromatography (HPLC), uncertainty

中图分类号: 

  • TQ658