化妆品用原花青素脂质体的制备及应用性能研究

doi:10.13218/j.cnki.csdc.2014.03.033

摘要/Abstract

摘要： 采用逆相蒸发法制备了化妆品用的原花青素脂质体,考察了原花青素与卵磷脂的质量比(药脂比)、聚乙二醇(PEG 1500)的用量对脂质体稳定性和包封率的影响。实验发现,随着药脂比或PEG 1500用量的增加,脂质体的包封率均呈先增加后降低的趋势。在m(原花青素)∶m(卵磷脂)=1∶20,m(卵磷脂)∶m(PEG 1500)=3∶1的较优条件下,得到的原花青素脂质体的包封率为77.28%,平均粒径为144.9 nm,透射电镜下观察其外观为球形或椭球形。同时研究了最优条件下原花青素脂质体的保湿性能,实验证明原花青素脂质体的保湿性能明显优于游离的原花青素溶液。

关键词: 化妆品, 脂质体, 原花青素, 保湿性能

Abstract: Proanthocyanidin liposome for cosmetics was prepared by reverse phase evaporation method.Effect of mass ratio of proanthocyanidin to lecithin and dosage of PEG 1500 on stability and extent of the encapsulation of the liposome product were examined.Results showed that the extent of encapsulation increases firstly and then decreases later as the increase of both mass ratio of proanthocyanidin to lecithin and the dosage of PEG 1500.Under conditions of m(proanthocyanidin)∶m(lecithin)=1∶20 and m(lecithin)∶m(PEG 1500)=3∶1,the extent of encapsulation achieves 77.28%,with an average value of particle size of 144.9 nm.The morphology of the liposome particle is spherical or ellipsoidal as observed by transmission electron microscope.In addition,the moisturizing performance of the liposome under optimal conditions was also studied.The results proved that the moisture retention performance of proanthocyanidin liposome is significantly better than that of proanthocyanidin solution without encapsulation of the liposome.

Key words: cosmetics, liposome, proanthocyanidin, moisture retention performance

中图分类号:

TQ658

郭芳, 胡国胜, 奚朝晖, 王一宇, 林苗. 化妆品用原花青素脂质体的制备及应用性能研究[J]. 日用化学工业, 2014, 44(3): 143-146.

GUO Fang, HU Guo-sheng, XI Zhao-hui, WANG Yi-yu, LIN Miao. Preparation and application performance of proanthocyanidin liposome for cosmetics[J]. China Surfactant Detergent & Cosmetics, 2014, 44(3): 143-146.

参考文献

[1] BANGHAM A D.Diffusi on of univalent ions across the lamellae of swollen phospholipids[J].J Mol Biol,1965,13:238-252.
[2] 廖金燕,林苗.人参水提取液脂质体的制备及包封率的测定[J].香料香精化妆品,2010(3):36-39.
[3] 穆筱梅,钟振声,陈焕钦.聚乙烯醇包覆的果酸脂质体的制备及性质研究[J].日用化学工业,2003,33(4):231-233.
[4] 穆筱梅,钟振声,杨梅.化妆品用果酸脂质体的制备研究[J].日用化学工业,2002,32(5):27-29.
[5] 张灵芝.脂质体制备及其在生物医学中的应用[M].北京:北京医科大学中国协和医科大学联合出版社,1998.
[6] 张伟光,姜国玉,康慧珏.磷脂与脂质体技术[M].哈尔滨:哈尔滨工程大学出版社,2010.
[7] 吕洛,魏少敏,林惠芬,等.脂质体载药系统经皮给药的研究进展[J].日用化学工业,2002,32(5):51-54.
[8] 杨桂明,谷健梅,宋丽艳,等.脂质体技术在化妆品制剂中的应用[J].中国美容医学,2009,18(3):396-398.
[9] 施靖,王红芳.脂质体作为药物载体的研究[J].中国医药导报,2008,5(11):29-30.
[10] 卢耀勤.葡萄精华软胶囊的制备工艺及降脂作用的研究[D].乌鲁木齐:新疆医科大学,2008.
[11] 蔚新,李华,高锦明.葡萄籽提取物研究进展[J].酿酒科技,2005(2):71-74.
[12] CALABRESE G.Table grape nutritional value[J].Bulletin de l'OIV,2003,76(1):124-133.
[13] PAOLA C,MAURIZIO C,PAOLA B,et al.Preparation,characterization and properties of sterically stabilized paclitaxel-containing liposomes[J].Journal of Controlled Release,2000,63:19-30.
[14] ŠTÊPÁN K,JOSEF M,JIRI N.Lyophilised liposome-based formulations of α-tocopheryl succinate:Preparation and physico-chemical characterisation[J].Journal of Pharmaceutical Sciences,2010,99(5):2434-2443.
[15] MARIA L I,PAOLA B,SILVIA A,et al.Preparation,characterization,cytotoxicity and pharmacokinetics of liposomes containing docetaxel[J].Journal of Controlled Release,2003,91:417-429.
[16] 胡博,姚薇薇,刘宁.原花青素脂质体的制备条件优化[J].东北农业大学学报,2010,41(9):106-111.
[17] 杜小豪,徐卫,杜雪洁.护肤产品的保湿功能评价[J].日用化学工业,2000,30(6):47-52.
[18] 宫崎幸习,平木吉夫.保湿剂、保湿性能化妆品的现状与今后展望[J].Fragrance Journal,1990(2):30-36
[19] ZHAO LIPING,XIONG HUA,PENG HAILONG.PEG-coated lyophilized proliposomes:preparation,characterizations and in vitro release evaluation of vitamin E[J].Eur Food Res Technol,2011,232:647-654.
[20] 陈婷婷,曹光群,杨成.聚乙二醇包覆的维生素C脂质体的制备及性质研究[J].大豆科学,2008,27(3):505-508.
[21] 周存款.多西他赛脂质体稳定性研究[D].天津:天津大学,2008.
[22] 李彦辉.PEG修饰的长春瑞滨脂质体的研究[D].石家庄:河北医科大学,2010.
[23] 陈婷婷.维生素C脂质体的研究[D].无锡:江南大学,2008.