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日用化学工业（中英文）

日用化学工业 ›› 2016, Vol. 46 ›› Issue (7): 423-426.doi: 10.13218/j.cnki.csdc.2016.07.013

• 分析与检测 • 上一篇    

高效液相色谱法同时测定化妆品中15种防晒剂

唐娜,罗晶,黄佳,戴涌   

  1. 陕西省食品药品检验所,陕西 西安 710065
  • 出版日期:2016-07-22 发布日期:2019-04-18
  • 作者简介:唐娜(1981-),女,陕西人,主管药师,博士,E-mail:tnlb2000@126.com。
  • 基金资助:
    陕西省科学技术发展计划资助项目(2012K17-02-03)

Simultaneous determination of 15 kinds of sun screener in cosmetics by HPLC

TANG Na,LUO Jing,HUANG Jia,DAI Yong   

  1. Shaanxi Institute for Food and Drug Control,Xi'an,Shaanxi 710065,China
  • Online:2016-07-22 Published:2019-04-18

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摘要： 优化和改进了《化妆品卫生规范》(2007年版)规定的测定化妆品中15种防晒剂的高效液相色谱法。样品经V(甲醇)∶V(四氢呋喃)∶V(水)∶V(0.067%高氯酸)=250∶450∶300∶0.2的混合溶液提取后,使用Kromasil C18色谱柱分离,以甲醇、四氢呋喃和0.067%高氯酸的混合溶液为流动相进行梯度洗脱,流速1 mL/min,检测波长311 nm。结果表明:在给定的质量浓度范围内15种防晒剂的峰面积与质量浓度呈良好的线性关系,方法回收率为85.6%～115.9%,检出限为0.8～12.5 ng。

关键词: 化妆品, 防晒剂, 高效液相色谱法

Abstract: HPLC method for determination of 15 kinds of sun screener used in cosmetics specified in Cosmetic Health Norm (2007 edition) was optimized and improved.The sample was extracted with a mixed solution composed of V(methanol)∶V(tetrahydrofuran,THF)∶V(water)∶V(0.067% perchloric acid)=250∶450∶300∶0.2 and separated with methanol-THF-0.067% perchloric acid as mobile phase with gradient elution on Kromasil C18 analytical column,at flow rate of 1 mL/min,and detector wavelength of 311 nm.The method shows good linear relationship in conventionally proper mass concentration range;the spiked recoveries are between 85.6%-115.9%;the detectable limit is within 0.8-12.5 ng.

Key words: cosmetics, sun screener, high performance liquid chromatography

中图分类号: 

  • TQ658