水解透明质酸锌的抗痤疮功效研究

doi:10.3969/j.issn.1001-1803.2023.02.006

Abstract

Abstract:

In this study, the effects of hydrolysed zinc hyaluronan （HA-ZN） on lipid production and skin hydration were revealed. The HaCaT and SZ95 cell lines were applied to evaluate the toxicity and beneficial effect of hydrolysed zinc hyaluronan. Pro-acne agents, arachidonic acid was used to induce the lipid production of SZ95 and the effect of hydrolysed zinc hyaluronan was detected. At the same time, in vitro antibacterial experiment against acne-related bacteria and the expression of skin hydration involved proteins were estimated. At the identical concentration of zinc ion, hydrolysed zinc hyaluronan exhibits less toxicity than zinc chloride, suggesting a higher safe dosage of zinc ion. In addition, hydrolysed zinc hyaluronan possesses the ability of alleviating lipid production in SZ95, as well as inhibiting the growth of Propionibacterium acnes and Malassezia furfur in vitro. The expression of AQP3 and HAS2 is also augmented in hydrolysed zinc hyaluronan treated group. The results indicate that hydrolysed zinc hyaluronan might be a promising drug candidate against acne vulgaris, averting the side effects of existing drugs such as dry skin.

Key words: acne vulgaris, skin hydration, zinc salt, hydrolysed zinc hyaluronan

CLC Number:

TQ658

Chen Fan,Yang Jun,Yang Suping,Wu Yue. Hydrolysed zinc hyaluronan, a novel anti-acne candidate[J].China Surfactant Detergent & Cosmetics, 2023, 53(2): 165-170.

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References 25

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Hydrolysed zinc hyaluronan, a novel anti-acne candidate

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