AIMP1衍生肽的护肤功效研究

doi:10.3969/j.issn.1001-1803.2023.02.007

Abstract

Abstract:

Advanced glycation end-products （AGEs） are produced during protein glycation and associated with skin ageing. The AIMP1 derived peptide （AdP） which is derived from aminoacyl tRNA synthase interacting multifunctional protein 1 may be used as an inhibitor of glycation. This study evaluated the potential anti-glycation effect of AdP and its application in cosmetic. Thirty valid subjects were selected as the research subjects, and non-invasive instruments were used to detect and record the water content, TEWL, R2, ITA°, wrinkle area/AOI area in the test group and the control group at 0, 4 and 8 weeks using corresponding products. The results show that the glycosylation reaction between BSA and glucose is inhibited by AdP, and the formation of protein carbonyl is reduced in a concentration-dependent manner. The applications of AdP in cosmetic has significant effects on improving the stratum corneum water content, the R2 value, the ITA° value, and the reducing the TEWL value and wrinkles. These findings suggest that AdP may serve as an inhibitor of glycation and provide new insights into its application.

Key words: AIMP1 derived peptide, anti-glycosylation, efficacy study

CLC Number:

TQ658

Yang Xiufen,Ma Wenjun,Li Lei,Wang Peipei,Zheng Chunyang. Study on skin care efficacy of AIMP1 derived peptide[J].China Surfactant Detergent & Cosmetics, 2023, 53(2): 171-179.

Figures/Tables 18

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References 27

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AdP质量浓度/ （mg/mL）	12 h累计透过量/ （μg/cm²）	24 h累计透过量/ （μg/cm²）
5	667±19	1 131±30
10	993±21	2 056±13
20	1 719±17	3 715±27

组别		时间/h	1级反应（例）	反应率/%（30例）
AdP		0.5	2	6.67
	0.1%	24	1	3.33
		48	0	0
		0.5	1	3.33
	0.05%	24	0	0
		48	0	0
		0.5	0	0
	0.01%	24	0	0
		48	0	0
阳性对照	0.02% SLS	0.5	4	13.33
		24	5	16.67
		48	3	10.00
阴性对照	蒸馏水	0.5	1	3.33
		24	0	0
		48	0	0

t/周	角质层含水量		与0周的差值
t/周	测试组	空白组	测试组	空白组
0	23.57±4.32	22.68±4.96
4	26.19±6.19	23.91±5.27	2.62	1.23
8	30.01±5.62	26.05±5.72	6.44	3.37

t/周	TEWL/ （g/ （cm²·h））		与0周的差值
t/周	测试组	空白组	测试组	空白组
0	19.34±4.74	18.25±5.38
4	17.76±5.37	17.55±5.26	-1.58	-0.7
8	16.87±4.98	17.17±4.79	-2.47	-1.08

t/周	弹性R2值		与0周的差值
t/周	测试组	空白组	测试组	空白组
0	0.521 5±0.052 3	0.522 8±0.054 1
4	0.552 1±0.062 6	0.531 6±0.064 2	0.030 6	0.008 8
8	0.575 4±0.078 3	0.532 1±0.065 3	0.053 9	0.009 3

Study on skin care efficacy of AIMP1 derived peptide

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t/周	ITA°		与0周的差值
t/周	测试组	空白组	测试组	空白组
0	31.29±5.78	31.42±5.48
4	34.59±5.53	32.23±5.56	3.3	0.81
8	35.75±6.71	33.03±6.10	4.46	1.61

t/周	皱纹面积占比/%		与0周的差值
t/周	测试组	空白组	测试组	空白组
0	9.72±0.32	9.37±0.51
4	9.1±0.45	9.21±0.47	-0.62	-0.16
8	8.54±0.57	8.97±0.49	-1.18	-0.40