Abstract:

Explore the mechanism of anti-sensitive skin effect of cosmetic raw material Stephania tetrandra on sensitive skin using a network pharmacological approach. The main chemical components of Stephania tetrandra were collected through TCMSP, CNKI, PubMed and other databases, and their targets were predicted using Swiss Target Prediction, intersected with the disease targets obtained from Genecards database and then used String database to construct protein interaction （PPI） network. Cytoscape3.9.1 software was used to analyze the core targets, and the DAVID online database was used to perform GO functional analysis and KEGG pathway enrichment analysis on the core targets. The results of GO enrichment analysis show that the 39 core targets are mainly involved in various biological processes such as protein phosphorylation, signal transduction, transcriptional regulation and gene expression. The results of KEGG pathway enrichment analysis show that the anti-sensitive skin effect of Stephania tetrandra may be closely related to VEGF signaling pathway, HIF-1 signaling pathway, ErbB signaling pathway and PI3K-Akt signaling pathway. The active ingredients in Stephania tetrandra, such as Dicentrined, Cepharanthine and Fangchinoline, may exert their anti-sensitive skin effects by acting on the targets of JAK2, JAK3 and SYC, reflecting the multicomponent-multitarget-multipathway action characteristics of Stephania tetrandra.

Key words: network pharmacology, cosmetics, Stephania tetrandra, sensitive skin