三七不同提取物舒缓功效对比研究

doi:10.3969/j.issn.2097-2806.2026.08.010

Abstract

Abstract:

In this study, we investigated the effects of different extracts of Panax notoginseng （PNT） on cell protection, barrier repair, and the alleviation of inflammatory response and neurological response, and evaluated the soothing efficacy of these extracts. The results show that different extracts of PNT significantly inhibit the red blood cell hemolysis rate and hyaluronidase activity, reduce the levels of the inflammatory cytokines IL-6 and TNF-α in stimulated cells, and inhibit intracellular Ca²⁺ influx. Furthermore, total saponins of PNT and total polysaccharides of PNT significantly increase the survival rate of KC cells after UVB irradiation, promote KC migration following SLS-induced injury, upregulate the expression of key barrier repair proteins （ZO-1 and claudin-1）, and significantly inhibit the capsaicin-induced expression of TRPV1 and TRPM2 proteins. In conclusion, various PNT extracts exhibit strong soothing properties, with PNT saponins demonstrating superior soothing efficacy compared to PNT flavonoids and PNT polysaccharides.

Key words: soothing efficacy evaluation, Panax notoginseng extract, inflammation, skin barrier repair, neurogenic response

CLC Number:

TQ658

Zhiming He, Jiawen Huang, Yi Zhan, Desong Wu, Yufeng Zha. Comparative study on the soothing efficacy of different extracts of Panax notoginseng[J].China Surfactant Detergent & Cosmetics, 2026, 56(8): 1053-1061.

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References 19

[1]	谭淇丹, 毕永贤, 刘蕾, 等. 化妆品舒缓功效评价的研究现状[J]. 日用化学工业 (中英文), 2023, 53(2): 193-201.
[2]	冯法晴, 李静. 化妆品舒缓功效的科学评价方法[J]. 日用化学工业 (中英文), 2023, 53(7): 816-825.
[3]	潘嘉, 王家葵. 三七功效本草考证[J]. 中国中药杂志, 2003 (6): 43-44.
[4]	周明, 安全, 翟文丽, 等. 三七总皂苷改善皮肤老化的探究[J]. 香料香精化妆品, 2023 (5): 86-92.
[5]	王子平, 华燕. 三七茎叶化学成分及药理作用研究概况[J]. 中国民族民间医药, 2008 (1): 76-78.
[6]	聂丽, 罗万芳, 王兴文. 大孔树脂分离纯化三七黄酮类成分研究[J]. 云南中医学院学报, 2007 (1): 10-12.
[7]	张培凤, 钟小超, 胡胜兵, 等. 透明质酸酶活性抑制实验的影响因素研究[J]. 精细与专用化学品, 2023, 31(8): 43-45.
[8]	吴剑萍, 李思祥, 李琪, 等. 透明质酸酶体外活性抑制抗过敏模型测定活性胶原蛋白的抗敏抗炎功效[J]. 日用化学品科学, 2024, 47(5): 22-25.
[9]	Fan L, He C, Jiang L, et al. Brief analysis of causes of sensitive skin and advances in evaluation of anti-allergic activity of cosmetic products[J]. International Journal of Cosmetic Science, 2016, 38(2): 120-127. doi: 10.1111/ics.12283 pmid: 26444676
[10]	王丽, 潘乙怀, 邹多宏. 不同来源成纤维细胞对角质形成细胞再上皮化影响[J]. 口腔材料器械杂志, 2024, 33(3): 150-157.
[11]	Chen L Y, Lin K R, Chen Y J, et al. Palmitoyl acyltransferase activity of ZDHHC13 regulates skin barrier development partly by controlling PADI3 and TGM1 protein stability[J]. Journal of Investigative Dermatology, 2020, 140(5): 959-970. doi: S0022-202X(19)33323-8 pmid: 31669413
[12]	Malminen M, Koivukangas V, Peltonen J, et al. Immunohistological distribution of the tight junction components ZO-1 and occludin in regenerating human epidermis[J]. British Journal of Dermatology, 2003, 149(2): 255-260. pmid: 12932229
[13]	Roeding Joachim, Maurin V, 陆婕, 等. 4-叔丁基环己醇: 敏感肌肤的“舒缓调节器”[J]. 中国化妆品, 2010 (5): 79-81.
[14]	蔡义文, 刘媛, 宋闯, 等. 化妆品抗敏安全性评价模型的研究进展[J]. 日用化学品科学, 2021, 44(3): 48-54.
[15]	Cao E, Liao M, Cheng Y, et al. TRPV1 structures in distinct conformations reveal activation mechanisms[J]. Nature, 2013 (504): 113-118.
[16]	Caterina M J, Schumacher M A, Tominaga M, et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway[J]. Nature, 1997 (389): 816-824.
[17]	Yiangou Y, Facer P, Dyer N H, et al. Vanilloid receptor 1 immunoreactivity in inflamed human bowel[J]. Lancet, 2001 (357): 1338-1339.
[18]	Xie Bo. Effect of magnolol and honokiol on the activation of transient receptor potential channel (TRP) and itch relief[D]. Beijing: Peking Union Medical College, 2019.
[19]	吴艳, 陈璨, Peter M Elias, 等. 钙离子对表皮屏障功能的调节[J]. 临床皮肤科杂志, 2010, 39(2): 135-137.

Comparative study on the soothing efficacy of different extracts of Panax notoginseng

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