一种植物复合物缓解日常洗护致头皮敏感的功效及作用机制研究

doi:10.3969/j.issn.2097-2806.2026.08.007

Abstract

Abstract:

Nowadays, shampoos and conditioners are used as routine hair care products in daily life. Frequent exposure to surfactants or their residues more or less causes damage to scalp skin. Herein, an in vitro model was constructed to simulate skin irritation induced by shampoo and hair conditioner, followed by the screening of multiple commercially available plant extracts. Scutellaria alpine, Epilobium angustifolium and Lavandula angustifolia were identified as strong cell protectors and formulated into a scalp soothing complex （SSC）. The SSC was further studied in both a keratinocyte model and a 3D reconstructed human epidermal model, for its effect in counteracting surfactant-induced damage. After a comprehensive evaluation including inflammatory markers, epidermal tissue morphology, and barrier proteins, SSC demonstrates that it is a strong, holistic solution to combat surfactant irritation. Specifically, SSC reduces the production of inflammatory cytokines IL-6 and IL-8, as well as the inflammatory mediator PGE2, upregulates endogenous NRF2 expression to enhance free radical scavenging; promotes the synthesis of key barrier proteins FLG and LOR; and downregulates TRPV1 expression. The current research suggests that SSC modulates barrier function, inflammatory responses, and neuro-sensory signaling through a multi-target regulatory mechanism, thereby exhibiting significant soothing efficacy and strong potential for scalp care applications.

Key words: plant extract, sensitive scalp, surfactants, skin barrier, in vitro model

CLC Number:

TQ658

Yuanyuan Fang, Qian Zhang, Mengxue Gao, Yubing Wang, Xiaowei Chang. A plant-derived complex attenuates surfactant-induced scalp sensitivity: efficacy and underlying mechanisms[J].China Surfactant Detergent & Cosmetics, 2026, 56(8): 1027-1037.

Figures/Tables 7

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References 35

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	Scutellaria alpine	Lavandula angustifolia	Epilobium angustifolium
Cell viability （SDS model） /%	118.93	107.24	105.09
Cell viability （CTAC model） /%	107.33	113.38	116.21

A plant-derived complex attenuates surfactant-induced scalp sensitivity: efficacy and underlying mechanisms

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