植物甾醇（酯）的研究与应用前景

doi:10.3969/j.issn.1001-1803.2023.04.011

Abstract

Abstract:

The latest research progress of phytosterols （esters） has been summarized, including synthetic methods, functions, related physicochemical modification and applications, with emphasis on the applications in cosmetics. The synthetic methods of phytosterol esters mainly include chemical catalytic method, ionic liquid catalytic method, solvent-free direct esterification and biological enzyme catalytic method. Biological enzyme catalytic method is the current focus of academic research, and it is expected to gradually replace chemical catalytic method in industrial production to become the mainstream method. Meanwhile, phytosterols have the functions of reducing cholesterol, antioxidation, anti-cancer, anti-inflammation, skin barrier repair and anti-bacteria. Phytosterols have various modification means such as esterification, emulsification, microencapsulation, nano-carrier, ethoxylation and polyethylene glycol modification. Therefore, they have been widely used in cosmetic industry, as well as in food, health care, pharmaceuticals, agriculture and livestock industry. Particularly, phytosterol oleate is developing rapidly.

Key words: phytosterol ester, cosmetics, research progress, application prospect

CLC Number:

TQ658

Wang Xiaokang, Chen Wen, Zhang Taijun, Yin Zhigang, Gu Yulong, Li Tao. Research and application prospect of phytosterols （esters）[J].China Surfactant Detergent & Cosmetics, 2023, 53(4): 445-452.

Figures/Tables 3

Fig. 1

Tab. 1

Tab. 2

References 42

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作用	实验项目	用量	效果
对皮肤细胞的促进增殖和抑制凋亡的作用	细胞培养燕麦甾醇对胶原蛋白生成的促进	10 μg/mL	促进率：35%
	细胞培养β-谷甾醇对纤维芽细胞增殖的促进	10 μg/mL	促进率：22%
	细胞培养麦角甾醇对成纤维细胞增殖的促进	80 μg/mL	促进率：8%
	在UVB照射下麦角甾醇对成纤维细胞凋亡的抑制	0.5 μg/mL	抑制率：28.1%
	β-谷甾醇对黑色素细胞B-16细胞活性的抑制	5 μg/mL	抑制率：56%
保湿作用	豆甾醇对经皮水分散失的抑制	2%	抑制率：34.6%
保湿作用	β-谷甾醇对经皮水分散失的抑制	5 μg/mL	抑制率：32.5%
抗氧化作用	豆甾醇对·OH的消除	/	半消除量EC₅₀：100 μg/mL
	豆甾醇对O₂^-·的消除	80 μg/mL	消除率：68.6%
	南瓜子植物甾醇对DPPH·的消除	2.0 mg/ml	消除率：53.9%
	β-谷甾醇对·OH的消除	120 μg/mL	消除率：69.1%
抗炎作用	二甲苯刺激下豆甾醇对小鼠耳朵肿胀的抑制	0.5%	抑制率：25.9%
	β-谷甾醇对金属蛋白酶MMP-1、MMP-3活性的抑制^*	0.005%	抑制率：28%、13%
	麦角甾醇对NF-κB细胞活性的抑制^*	250 μg/mL	抑制率：23.5%
	麦角甾醇对脂多糖诱发肿瘤坏死因子生成的抑制	120 μg/mL	抑制率：42.8%
生发作用	豆甾醇对小鼠毛发生长的促进	0.5%	促进率：83.4%
生发作用	麦角甾醇对小鼠毛发生长的促进	1%	促进率：40.5%

标准成分名称	不同年份备案产品数/款
标准成分名称	2021年	2020年	2019年	2018年	2017年	2016年	2015年	2014年
胆甾醇	6 589	6 175	5 065	3 406	2 422	1 344	1 345	971
植物甾醇类	4 174	3 801	3 941	3 344	2 312	1 467	1 439	844
植物甾醇油酸酯	3 535	2 724	2 611	1 589	841	393	249	110
植物甾醇/辛基十二醇月桂酰谷氨酸酯	2 255	2 132	2 361	1 907	1 445	1071	635	486
油菜（BRASSICA CAMPESTRIS）甾醇类	934	956	973	778	589	363	282	196
双-山嵛醇/异硬脂醇/植物甾醇二聚亚油醇二聚亚油酸酯	728	764	1032	999	599	295	447	140
植物甾醇异硬脂酸酯	710	761	991	774	439	240	206	91
野大豆（GLYCINE SOJA）甾醇类	577	781	503	505	371	131	122	76
β-谷甾醇	552	527	548	354	258	136	140	78
植物甾醇/异硬脂醇/鲸蜡醇/硬脂醇/山嵛醇二聚亚油酸酯	444	590	630	928	822	650	527	359

Research and application prospect of phytosterols （esters）

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