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China Surfactant Detergent & Cosmetics ›› 2023, Vol. 53 ›› Issue (4): 437-444.doi: 10.3969/j.issn.1001-1803.2023.04.010

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Research progress on physiological action and preparations of luteolin

Zhan Xin1,2,Xu Fan1,2,Zhu Jun1,2,*(),He Yifan1,2,Pei Xiaojing1,2   

  1. 1. Institute of Cosmetic Regulatory Science, Beijing Technology & Business University, Beijing 100048, China
    2. College of Chemistry and Materials Engineering, Beijing Technology & Business University, Beijing 100048, China
  • Received:2022-04-16 Revised:2023-03-30 Online:2023-04-22 Published:2023-04-25
  • Contact: * Tel.: +86-13661302748, E-mail: zhujun@btbu.edu.cn.

Abstract:

Luteolin is a natural flavonoid compound and can be used as cosmetic raw material. Studies have shown that luteolin can provide hydrogen atoms to react with free radicals to generate stable compounds and enhance the activity of antioxidant enzymes to achieve antioxidant effects. It can also inhibit the expression of inflammatory cytokines and inflammatory mediators by affecting multiple inflammatory signaling pathways. It can also delay aging by inhibiting kinases that affect skin aging and whiten the skin by inhibiting enzymes involved in the synthesis of melanin. However, the solubility and bioavailability of luteolin are poor since it is only slightly soluble both in hot water and in cold water. Its solubility and bioavailability can be improved by preparation technologies such as solid dispersion, cyclodextrin inclusion, phospholipid complexation, formation of solid lipid nanoparticles, nanostructured liposomes, nanomilk and polymer micelles, etc. However, some preparation technologies have the problems of high cost, short shelf life, instability, etc., and further research on the action mechanism of luteolin and related preparations is needed. The physiological action mechanisms of luteolin on the skin, as well as the research progress of its various preparation techniques, were reviewed, which could provide a reference for further preparation research and cosmetic product application.

Key words: luteolin, physiological function, cosmetic, preparation

CLC Number: 

  • TQ658