曲酸金属配合物的合成与酪氨酸酶抑制性能研究

doi:10.13218/j.cnki.csdc.2014.12.153

摘要/Abstract

摘要： 曲酸(KA)与4种金属离子配位反应得到相应的曲酸金属配合物KA-Fe(Ⅲ),KA-Cu(Ⅱ),KA-Mn(Ⅱ)和KA-Zn(Ⅱ),采用红外光谱、差热-热重分析和紫外光谱对其金属配合物进行了结构表征,并进行了对酪氨酸酶的抑制作用研究。结果表明,KA-Fe(Ⅲ),KA-Zn(Ⅱ)和KA-Mn(Ⅱ)对酪氨酸酶的抑制效果显著,对应的IC₅₀为25,18和62 μmol·L^-1(曲酸IC₅₀为70 μmol·L^-1),根据抑制机理分析,该系列金属配合物的抑制类型属于非竞争性抑制。

关键词: 化妆品添加剂, 曲酸金属配合物, 酪氨酸酶抑制剂, 非竞争性

Abstract: Four kinds of metal complex of kojic acid (KA),KA-Fe(Ⅲ),KA-Cu(Ⅱ),KA-Mn(Ⅱ) and KA-Zn(Ⅱ) were prepared by complexing reaction through kojic acid and metal ion compounds.Their chemical structures were characterized by infrared spectra,differential thermal gravimetric analysis and ultraviolet spectra.Their tyrosinase inhibitory action was examined.Results showed that the tyrosinase inhibitory effect of KA-Fe(Ⅲ),KA-Zn(Ⅱ) and KA-Mn(Ⅱ) are remarkable.Their corresponding IC₅₀ is 25,18 and 62 μmol·L^-1 respectively (while IC₅₀ of kojic acid is 70 μmol·L^-1).Based upon analysis of their inhibitory mechanism,the type of inhibitory action of this series of compound is all considered as non-competitive inhibition.

Key words: additive of cosmetics, kojic acid metal complex, tyrosinase inhibitor, non-competitive

中图分类号:

TQ658

杨培, 张逸伟. 曲酸金属配合物的合成与酪氨酸酶抑制性能研究[J]. 日用化学工业, 2014, 44(12): 688-691.

YANG Pei, ZHANG Yi-wei. Synthesis and tyrosinase inhibitory activity of kojic acid metal complexes[J]. China Surfactant Detergent & Cosmetics, 2014, 44(12): 688-691.

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