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日用化学工业（中英文）

日用化学工业 ›› 2021, Vol. 51 ›› Issue (10): 939-948.doi: 10.3969/j.issn.1001-1803.2021.10.003

• 科技讲座 • 上一篇    下一篇

化妆品乳液及乳化新技术（Ⅴ）——脂质体包载技术在经皮输送中的应用

张雅琪1,2,梁蓉1,2,*(),杨成1,2   

  1. 1. 江南大学 合成与生物胶体教育部重点实验室,江苏 无锡 214122
    2. 江南大学 化工与材料工程学院,江苏 无锡 214122
  • 修回日期:2021-09-29 出版日期:2021-10-22 发布日期:2021-10-21
  • 通讯作者: 梁蓉
  • 基金资助:
    国家自然科学基金资助项目(51903108)

Cosmetic emulsions and new technologies of emulsification (Ⅴ) Application of liposomes entrapment technology in transdermal delivery

Zhang Yaqi1,2,Liang Rong1,2,*(),Yang Cheng1,2   

  1. 1. Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Jiangnan University, Wuxi, Jiangsu 214122, China
    2. School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China
  • Revised:2021-09-29 Online:2021-10-22 Published:2021-10-21
  • Contact: Rong Liang

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摘要：

化妆品中所添加的活性成分往往存在光、热稳定性差,溶解性差等原因,需通过包载技术提高其生物利用度。在各种包载体系中,脂质体由于结构与人体皮肤细胞相似,且具有良好的生物相容性,是一种有效的包载方法。然而传统脂质体由于稳定性、可变形性差等原因难以通过皮肤屏障,达到促渗效果。如今,通过改变传统脂质体磷脂双层膜的结构获得了各种新型脂质体,如醇质体、类脂质体、传递体、磷脂复合物、甘油体等,新型脂质体由于稳定性良好、具有可变形性、可改变角质层脂质结构等特点,能够改善药物经皮输送效果。文章综述了几种新型脂质体,并对其透皮效果进行分析,旨在为化妆品包载领域提供借鉴和思路。

关键词: 脂质体, 透皮, 化妆品

Abstract:

The bioavailability of some active ingredients in cosmetics needs to be improved by nanoencapsulation technology due to their poor light/thermal stability and poor solubility. Among various encapsulation systems, liposomes are effective encapsulation method because of their similar structure to human skin cells and good biocompatibility. However, traditional liposomes are difficult to pass through the skin barrier due to their poor stability and deformability, it’s difficult to achieve the effect of promoting permeability. Nowadays, various new liposomes have been obtained by changing the structure of traditional liposomes’ phospholipid bilayer, such as ethosomes, niosomes, transferosomes, phytosomes, glycerosomes, etc. The effect of drug transdermal delivery has been improved by these new liposomes due to their good stability, deformability and the ability to change the lipid structure of stratum corneum. Herein, several new liposomes have been reviewed and their transdermal effects have been analyzed to provide reference and ideas for the field of cosmetic encapsulation.

Key words: liposomes, transdermal, cosmetics

中图分类号: 

  • TQ658